Single cell type - SRPRA - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SRPRA
Gene descriptionⁱ Full gene name according to HGNC.	SRP receptor subunit alpha
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Plasma cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Plasma cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SRPRA is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 1
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IGLV4-69	Immunoglobulin lambda variable 4-69	0.6649	55
IGLV3-27	Immunoglobulin lambda variable 3-27	0.6648	55
IGLV3-19	Immunoglobulin lambda variable 3-19	0.6596	55
IGHV1-2	Immunoglobulin heavy variable 1-2	0.6575	55
IGLV3-9	Immunoglobulin lambda variable 3-9	0.6560	55
IGLV2-11	Immunoglobulin lambda variable 2-11	0.6548	55
IGLV1-44	Immunoglobulin lambda variable 1-44	0.6545	55
IGLV3-21	Immunoglobulin lambda variable 3-21	0.6541	55
IGLV3-25	Immunoglobulin lambda variable 3-25	0.6528	55
IGLV6-57	Immunoglobulin lambda variable 6-57	0.6508	55
PIM2	Pim-2 proto-oncogene, serine/threonine kinase	0.6496	55
IGLV4-60	Immunoglobulin lambda variable 4-60	0.6467	55
IGLV1-47	Immunoglobulin lambda variable 1-47	0.6462	55
IGLV3-10	Immunoglobulin lambda variable 3-10	0.6461	55
AC233755.2		0.6446	55

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	52.9 nTPM
Adipose tissue	60.3 nTPM
Breast	45.5 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	69.3 nTPM
Lung	69.3 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	69.1 nTPM
Stomach	122.6 nTPM
Liver	114.5 nTPM
Adipose tissue	86.2 nTPM
Spleen	85.8 nTPM
Breast	80.3 nTPM
Lymph node	77.5 nTPM
Bone marrow	57.2 nTPM
PBMC	38.6 nTPM
Kidney	28.5 nTPM
Colon	0.0 nTPM

Dendritic cells	81.7 nTPM
Adipose tissue	110.1 nTPM
PBMC	87.6 nTPM
Breast	47.4 nTPM

Endothelial cells	36.5 nTPM
Pancreas	65.6 nTPM
Esophagus	58.9 nTPM
Eye	53.4 nTPM
Ovary	49.7 nTPM
Skeletal muscle	49.4 nTPM
Endometrium	46.5 nTPM
Lung	37.4 nTPM
Prostate	36.9 nTPM
Breast	29.8 nTPM
Placenta	29.0 nTPM
Testis	28.5 nTPM
Liver	25.7 nTPM
Heart muscle	0.0 nTPM
Skin	0.0 nTPM

Fibroblasts	42.9 nTPM
Lung	74.8 nTPM
Stomach	66.9 nTPM
Prostate	61.2 nTPM
Adipose tissue	59.5 nTPM
Esophagus	56.3 nTPM
Skeletal muscle	55.3 nTPM
Breast	40.6 nTPM
Placenta	28.9 nTPM
Ovary	28.1 nTPM
Heart muscle	0.0 nTPM
Skin	0.0 nTPM

Intestinal goblet cells	14.2 nTPM
Small intestine	25.3 nTPM
Rectum	17.1 nTPM
Colon	0.0 nTPM

Macrophages	43.4 nTPM
Lung	64.8 nTPM
Endometrium	58.1 nTPM
Adipose tissue	55.6 nTPM
PBMC	54.6 nTPM
Bone marrow	48.7 nTPM
Stomach	46.9 nTPM
Skeletal muscle	41.6 nTPM
Esophagus	40.9 nTPM
Testis	40.1 nTPM
Spleen	39.4 nTPM
Breast	35.2 nTPM
Prostate	33.2 nTPM
Kidney	31.0 nTPM
Pancreas	30.7 nTPM
Ovary	30.2 nTPM

Paneth cells	9.5 nTPM
Rectum	21.0 nTPM
Small intestine	7.5 nTPM
Colon	0.0 nTPM

Plasma cells	232.5 nTPM
Stomach	418.3 nTPM
Spleen	241.9 nTPM
Bone marrow	217.5 nTPM
Esophagus	172.5 nTPM
Adipose tissue	112.3 nTPM

Respiratory ciliated cells	21.1 nTPM
Lung	42.3 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	30.7 nTPM
Pancreas	80.4 nTPM
Skeletal muscle	48.4 nTPM
Prostate	41.3 nTPM
Adipose tissue	35.8 nTPM
Endometrium	34.2 nTPM
Esophagus	34.1 nTPM
Ovary	32.8 nTPM
Breast	30.3 nTPM
Heart muscle	0.0 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	64.3 nTPM
Stomach	133.8 nTPM
Adipose tissue	116.8 nTPM
Spleen	95.6 nTPM
Lung	94.2 nTPM
Bone marrow	83.4 nTPM
Lymph node	81.1 nTPM
Prostate	71.1 nTPM
Skeletal muscle	64.6 nTPM
Endometrium	61.8 nTPM
Esophagus	58.9 nTPM
PBMC	58.8 nTPM
Ovary	51.2 nTPM
Kidney	45.8 nTPM
Breast	44.1 nTPM
Liver	32.5 nTPM
Colon	0.0 nTPM
Skin	0.0 nTPM

Basal prostatic cells	53.5 nTPM
Prostate	53.5 nTPM

Basal squamous epithelial cells	44.9 nTPM
Esophagus	44.9 nTPM

Cholangiocytes	32.9 nTPM
Liver	32.9 nTPM

Collecting duct cells	22.0 nTPM
Kidney	22.0 nTPM

Undifferentiated cells	9.5 nTPM
Rectum	14.8 nTPM
Small intestine	13.7 nTPM
Colon	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC