Single cell type - DAZAP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DAZAP2
Gene descriptionⁱ Full gene name according to HGNC.	DAZ associated protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DAZAP2 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GMIP	GEM interacting protein	0.6922	58
MAT2B	Methionine adenosyltransferase 2B	0.6811	59
NBPF26	NBPF member 26	0.6805	59
STAT1	Signal transducer and activator of transcription 1	0.6767	58
MMP8	Matrix metallopeptidase 8	0.6588	19
GNG10	G protein subunit gamma 10	0.6304	59
RWDD3	RWD domain containing 3	0.6254	59
ARPC4-TTLL3	ARPC4-TTLL3 readthrough	0.6176	59
JAK3	Janus kinase 3	0.6103	58
DEFA3	Defensin alpha 3	0.6102	58
HMGN4	High mobility group nucleosomal binding domain 4	0.6031	59
RNASEK	Ribonuclease K	0.6026	59
ZGPAT	Zinc finger CCCH-type and G-patch domain containing	0.5945	59
TRIM22	Tripartite motif containing 22	0.5911	57
SPIC	Spi-C transcription factor	0.5898	19

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	116.7 nTPM
Adipose tissue	148.9 nTPM
Breast	84.5 nTPM

Alveolar cells type 1	144.2 nTPM
Lung	144.2 nTPM

Alveolar cells type 2	205.1 nTPM
Lung	205.1 nTPM

Astrocytes	19.6 nTPM
Brain	19.6 nTPM

B-cells	271.9 nTPM
Stomach	497.3 nTPM
Spleen	364.8 nTPM
Lymph node	357.1 nTPM
Bone marrow	348.2 nTPM
Adipose tissue	250.7 nTPM
Kidney	247.6 nTPM
Colon	215.7 nTPM
PBMC	214.1 nTPM
Liver	159.6 nTPM
Breast	64.1 nTPM

Basal squamous epithelial cells	167.9 nTPM
Esophagus	167.9 nTPM

Dendritic cells	167.4 nTPM
Adipose tissue	225.3 nTPM
PBMC	183.3 nTPM
Breast	93.7 nTPM

Endothelial cells	138.3 nTPM
Esophagus	214.0 nTPM
Heart muscle	192.1 nTPM
Prostate	181.2 nTPM
Skin	162.4 nTPM
Breast	143.5 nTPM
Pancreas	139.0 nTPM
Testis	133.3 nTPM
Liver	131.2 nTPM
Eye	127.0 nTPM
Lung	109.2 nTPM
Skeletal muscle	105.1 nTPM
Endometrium	101.3 nTPM
Placenta	101.2 nTPM
Ovary	95.5 nTPM

Enteroendocrine cells	126.3 nTPM
Colon	138.6 nTPM
Rectum	114.1 nTPM

Erythroid cells	155.6 nTPM
Bone marrow	161.4 nTPM
Liver	149.9 nTPM

Fibroblasts	108.0 nTPM
Stomach	191.6 nTPM
Heart muscle	165.3 nTPM
Esophagus	160.5 nTPM
Prostate	132.8 nTPM
Adipose tissue	126.2 nTPM
Skin	118.9 nTPM
Breast	74.1 nTPM
Skeletal muscle	66.4 nTPM
Lung	61.4 nTPM
Placenta	49.4 nTPM
Ovary	41.2 nTPM

Intestinal goblet cells	230.6 nTPM
Colon	249.5 nTPM
Rectum	224.8 nTPM
Small intestine	217.4 nTPM

Macrophages	282.0 nTPM
Spleen	477.0 nTPM
Bone marrow	474.8 nTPM
Stomach	468.8 nTPM
Kidney	431.9 nTPM
Adipose tissue	323.4 nTPM
Testis	295.1 nTPM
Esophagus	283.3 nTPM
Pancreas	237.4 nTPM
Skeletal muscle	228.2 nTPM
Prostate	206.4 nTPM
Lung	205.5 nTPM
PBMC	177.3 nTPM
Endometrium	175.0 nTPM
Ovary	141.4 nTPM
Breast	104.4 nTPM

Paneth cells	275.8 nTPM
Colon	355.7 nTPM
Small intestine	240.3 nTPM
Rectum	231.5 nTPM

Plasma cells	169.5 nTPM
Stomach	226.3 nTPM
Spleen	193.4 nTPM
Bone marrow	158.2 nTPM
Esophagus	135.4 nTPM
Adipose tissue	134.2 nTPM

Cholangiocytes	165.8 nTPM
Liver	165.8 nTPM

Collecting duct cells	235.4 nTPM
Kidney	235.4 nTPM

Cone photoreceptor cells	58.4 nTPM
Eye	58.4 nTPM

Cytotrophoblasts	55.8 nTPM
Placenta	55.8 nTPM

Respiratory ciliated cells	155.9 nTPM
Bronchus	183.5 nTPM
Lung	128.2 nTPM

Smooth muscle cells	130.4 nTPM
Bronchus	280.8 nTPM
Heart muscle	245.5 nTPM
Esophagus	198.4 nTPM
Prostate	146.9 nTPM
Skeletal muscle	112.9 nTPM
Adipose tissue	93.9 nTPM
Skin	89.6 nTPM
Pancreas	78.9 nTPM
Breast	67.6 nTPM
Endometrium	66.4 nTPM
Ovary	53.4 nTPM

T-cells	249.6 nTPM
Stomach	470.7 nTPM
Spleen	422.5 nTPM
Bone marrow	392.0 nTPM
Lymph node	384.6 nTPM
Kidney	253.9 nTPM
Adipose tissue	249.6 nTPM
PBMC	246.3 nTPM
Esophagus	235.8 nTPM
Lung	227.8 nTPM
Colon	223.3 nTPM
Liver	205.9 nTPM
Prostate	194.1 nTPM
Skin	187.5 nTPM
Skeletal muscle	168.2 nTPM
Ovary	144.6 nTPM
Endometrium	127.8 nTPM
Breast	108.8 nTPM

Undifferentiated cells	182.4 nTPM
Colon	201.9 nTPM
Rectum	188.4 nTPM
Small intestine	156.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC