Single cell type - KREMEN1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KREMEN1
Gene descriptionⁱ Full gene name according to HGNC.	Kringle containing transmembrane protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Fibroblasts - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Skeletal myocytes, Astrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (neutrophil, basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RH-30, U-2197)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Skeletal myocytes, Astrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

KREMEN1 is part of cluster 50 Fibroblasts - ECM organization with confidenceⁱ 1
441 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RGMA	Repulsive guidance molecule BMP co-receptor a	0.7115	50
NFIX	Nuclear factor I X	0.6777	50
CRLF1	Cytokine receptor like factor 1	0.6681	50
HMCN2	Hemicentin 2	0.6676	50
EVC2	EvC ciliary complex subunit 2	0.6635	50
ZIC1	Zic family member 1	0.6519	50
TRIL	TLR4 interactor with leucine rich repeats	0.6421	50
LTBP4	Latent transforming growth factor beta binding protein 4	0.6373	50
LTBP2	Latent transforming growth factor beta binding protein 2	0.6362	50
SMOC2	SPARC related modular calcium binding 2	0.6321	50
SSPN	Sarcospan	0.6262	50
PAX7	Paired box 7	0.6174	50
APCDD1L	APC down-regulated 1 like	0.6101	50
SSC5D	Scavenger receptor cysteine rich family member with 5 domains	0.6100	50
LAMA2	Laminin subunit alpha 2	0.6037	50

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	2.0 nTPM
Adipose tissue	2.3 nTPM
Breast	1.7 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	18.4 nTPM
Lung	18.4 nTPM

B-cells	0.3 nTPM
PBMC	2.8 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Basal keratinocytes	15.3 nTPM
Skin	15.3 nTPM

Dendritic cells	0.3 nTPM
Adipose tissue	0.6 nTPM
Breast	0.4 nTPM
PBMC	0.0 nTPM

Endothelial cells	3.9 nTPM
Heart muscle	9.4 nTPM
Skeletal muscle	6.9 nTPM
Lung	6.2 nTPM
Prostate	5.8 nTPM
Liver	5.5 nTPM
Skin	4.9 nTPM
Esophagus	4.2 nTPM
Endometrium	3.3 nTPM
Eye	2.4 nTPM
Testis	2.4 nTPM
Breast	2.3 nTPM
Ovary	1.0 nTPM
Placenta	0.6 nTPM
Pancreas	0.0 nTPM

Fibroblasts	24.4 nTPM
Stomach	52.0 nTPM
Skeletal muscle	40.2 nTPM
Esophagus	36.0 nTPM
Skin	30.2 nTPM
Adipose tissue	29.9 nTPM
Heart muscle	19.3 nTPM
Breast	18.3 nTPM
Ovary	15.9 nTPM
Prostate	11.2 nTPM
Lung	8.9 nTPM
Placenta	6.8 nTPM

Intestinal goblet cells	19.4 nTPM
Small intestine	23.4 nTPM
Colon	20.1 nTPM
Rectum	14.7 nTPM

Macrophages	2.5 nTPM
Pancreas	12.8 nTPM
Lung	6.5 nTPM
Skeletal muscle	6.0 nTPM
Kidney	2.3 nTPM
Prostate	2.2 nTPM
Endometrium	2.0 nTPM
Esophagus	1.6 nTPM
Adipose tissue	1.4 nTPM
Testis	1.2 nTPM
Breast	1.1 nTPM
Ovary	0.9 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	9.5 nTPM
Small intestine	22.5 nTPM
Rectum	6.1 nTPM
Colon	0.0 nTPM

Plasma cells	0.1 nTPM
Adipose tissue	0.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	18.4 nTPM
Bronchus	19.2 nTPM
Lung	17.5 nTPM

Smooth muscle cells	7.9 nTPM
Bronchus	17.2 nTPM
Heart muscle	14.9 nTPM
Ovary	11.0 nTPM
Skeletal muscle	10.3 nTPM
Esophagus	6.2 nTPM
Adipose tissue	5.9 nTPM
Skin	5.2 nTPM
Pancreas	4.7 nTPM
Prostate	4.3 nTPM
Endometrium	4.3 nTPM
Breast	2.6 nTPM

T-cells	2.3 nTPM
Prostate	14.2 nTPM
Skeletal muscle	8.0 nTPM
Skin	5.5 nTPM
Lung	4.5 nTPM
Endometrium	2.5 nTPM
Colon	1.4 nTPM
PBMC	1.4 nTPM
Liver	0.7 nTPM
Breast	0.7 nTPM
Adipose tissue	0.4 nTPM
Stomach	0.1 nTPM
Kidney	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Astrocytes	59.1 nTPM
Brain	59.1 nTPM

Cholangiocytes	14.3 nTPM
Liver	14.3 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Cytotrophoblasts	15.5 nTPM
Placenta	15.5 nTPM

Undifferentiated cells	10.2 nTPM
Small intestine	16.2 nTPM
Rectum	7.8 nTPM
Colon	6.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC