Single cell type - DENND5A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DENND5A
Gene descriptionⁱ Full gene name according to HGNC.	DENN domain containing 5A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DENND5A is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ATP13A3	ATPase 13A3	0.5657	41
TAOK1	TAO kinase 1	0.5643	10
HOOK3	Hook microtubule tethering protein 3	0.5273	44
YTHDF3	YTH N6-methyladenosine RNA binding protein 3	0.5244	44
ATP11A	ATPase phospholipid transporting 11A	0.5231	44
BTBD7	BTB domain containing 7	0.5120	44
NFIL3	Nuclear factor, interleukin 3 regulated	0.5107	41
RYBP	RING1 and YY1 binding protein	0.5098	42
MAP4K4	Mitogen-activated protein kinase kinase kinase kinase 4	0.5086	42
CREB5	CAMP responsive element binding protein 5	0.4970	50
AGTPBP1	ATP/GTP binding protein 1	0.4937	42
KMT2C	Lysine methyltransferase 2C	0.4933	44
IL1RL2	Interleukin 1 receptor like 2	0.4845	44
KIF13B	Kinesin family member 13B	0.4823	44
ZNF592	Zinc finger protein 592	0.4735	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	34.1 nTPM
Adipose tissue	36.6 nTPM
Breast	31.6 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	14.5 nTPM
Lung	14.5 nTPM

Astrocytes	43.8 nTPM
Brain	43.8 nTPM

B-cells	7.4 nTPM
Colon	12.8 nTPM
Kidney	9.5 nTPM
Breast	9.4 nTPM
Lymph node	9.1 nTPM
Spleen	9.0 nTPM
Adipose tissue	8.5 nTPM
PBMC	7.1 nTPM
Stomach	4.5 nTPM
Bone marrow	2.5 nTPM
Liver	1.8 nTPM

Dendritic cells	6.4 nTPM
PBMC	8.0 nTPM
Adipose tissue	5.8 nTPM
Breast	5.4 nTPM

Endothelial cells	31.3 nTPM
Prostate	77.3 nTPM
Endometrium	45.2 nTPM
Skin	43.4 nTPM
Eye	38.0 nTPM
Heart muscle	35.2 nTPM
Ovary	34.0 nTPM
Skeletal muscle	31.2 nTPM
Breast	30.6 nTPM
Esophagus	30.4 nTPM
Liver	18.3 nTPM
Testis	17.7 nTPM
Placenta	15.9 nTPM
Pancreas	11.6 nTPM
Lung	9.3 nTPM

Fibroblasts	27.1 nTPM
Prostate	53.4 nTPM
Skin	43.7 nTPM
Heart muscle	35.5 nTPM
Skeletal muscle	34.0 nTPM
Adipose tissue	31.0 nTPM
Ovary	20.5 nTPM
Esophagus	19.2 nTPM
Placenta	18.8 nTPM
Breast	16.5 nTPM
Stomach	13.4 nTPM
Lung	12.3 nTPM

Intestinal goblet cells	2.2 nTPM
Colon	2.9 nTPM
Small intestine	2.1 nTPM
Rectum	1.5 nTPM

Macrophages	48.9 nTPM
Adipose tissue	105.7 nTPM
Spleen	82.0 nTPM
Stomach	76.2 nTPM
Skeletal muscle	67.2 nTPM
Endometrium	57.1 nTPM
Lung	50.4 nTPM
Kidney	48.5 nTPM
Bone marrow	47.5 nTPM
Prostate	47.0 nTPM
Testis	45.3 nTPM
Esophagus	36.2 nTPM
Ovary	27.1 nTPM
Breast	23.4 nTPM
Pancreas	20.4 nTPM
PBMC	0.0 nTPM

Paneth cells	1.4 nTPM
Small intestine	3.7 nTPM
Rectum	0.6 nTPM
Colon	0.0 nTPM

Plasma cells	0.9 nTPM
Adipose tissue	3.9 nTPM
Spleen	0.6 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Stomach	0.0 nTPM

Respiratory ciliated cells	4.8 nTPM
Bronchus	6.7 nTPM
Lung	2.9 nTPM

Smooth muscle cells	31.6 nTPM
Adipose tissue	53.2 nTPM
Endometrium	44.8 nTPM
Skin	42.9 nTPM
Prostate	42.8 nTPM
Skeletal muscle	36.5 nTPM
Breast	29.4 nTPM
Ovary	28.9 nTPM
Heart muscle	28.8 nTPM
Pancreas	22.4 nTPM
Esophagus	15.5 nTPM
Bronchus	2.8 nTPM

T-cells	6.3 nTPM
Skin	14.3 nTPM
Endometrium	13.2 nTPM
PBMC	10.9 nTPM
Lymph node	9.3 nTPM
Ovary	8.9 nTPM
Skeletal muscle	8.5 nTPM
Esophagus	6.6 nTPM
Liver	5.7 nTPM
Spleen	5.5 nTPM
Adipose tissue	5.2 nTPM
Prostate	4.7 nTPM
Breast	3.9 nTPM
Kidney	3.4 nTPM
Colon	3.3 nTPM
Bone marrow	2.9 nTPM
Stomach	1.2 nTPM
Lung	0.0 nTPM

Basal keratinocytes	21.7 nTPM
Skin	21.7 nTPM

Basal prostatic cells	19.3 nTPM
Prostate	19.3 nTPM

Basal respiratory cells	10.3 nTPM
Bronchus	10.3 nTPM

Basal squamous epithelial cells	10.2 nTPM
Esophagus	10.2 nTPM

Undifferentiated cells	0.8 nTPM
Rectum	1.2 nTPM
Small intestine	0.9 nTPM
Colon	0.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC