Single cell type - NRBP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NRBP2
Gene descriptionⁱ Full gene name according to HGNC.	Nuclear receptor binding protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Astrocytes - Nervous system maintenance (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Astrocytes, Oligodendrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Astrocytes, Oligodendrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NRBP2 is part of cluster 64 Astrocytes - Nervous system maintenance with confidenceⁱ 1
169 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TMPRSS5	Transmembrane serine protease 5	0.7218	64
HEPACAM	Hepatic and glial cell adhesion molecule	0.7001	64
PLXNB3	Plexin B3	0.6763	64
KIAA1755	KIAA1755	0.6723	64
DAAM2	Dishevelled associated activator of morphogenesis 2	0.6689	42
HEPN1	Hepatocellular carcinoma, down-regulated 1	0.6628	64
AASS	Aminoadipate-semialdehyde synthase	0.6578	64
MEGF10	Multiple EGF like domains 10	0.6546	64
LSS	Lanosterol synthase	0.6204	15
ETNPPL	Ethanolamine-phosphate phospho-lyase	0.6194	64
ZNRF3	Zinc and ring finger 3	0.6095	64
NPFF	Neuropeptide FF-amide peptide precursor	0.6011	64
ZHX3	Zinc fingers and homeoboxes 3	0.5989	64
LRRC3C	Leucine rich repeat containing 3C	0.5893	64
PRDM16	PR/SET domain 16	0.5891	64

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	15.1 nTPM
Adipose tissue	17.3 nTPM
Breast	13.0 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	13.7 nTPM
Lung	13.7 nTPM

B-cells	2.0 nTPM
Breast	9.4 nTPM
Adipose tissue	4.0 nTPM
Liver	2.9 nTPM
Colon	1.6 nTPM
Spleen	1.0 nTPM
Stomach	0.5 nTPM
Lymph node	0.4 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Basal keratinocytes	9.2 nTPM
Skin	9.2 nTPM

Dendritic cells	3.2 nTPM
Adipose tissue	4.8 nTPM
Breast	4.7 nTPM
PBMC	0.0 nTPM

Endothelial cells	10.4 nTPM
Heart muscle	27.8 nTPM
Skeletal muscle	14.9 nTPM
Testis	14.5 nTPM
Eye	13.7 nTPM
Ovary	12.4 nTPM
Breast	12.1 nTPM
Pancreas	7.7 nTPM
Liver	7.3 nTPM
Endometrium	6.9 nTPM
Skin	6.8 nTPM
Lung	6.2 nTPM
Placenta	5.1 nTPM
Prostate	4.8 nTPM
Esophagus	4.6 nTPM

Fibroblasts	11.2 nTPM
Adipose tissue	23.7 nTPM
Skeletal muscle	18.6 nTPM
Breast	13.4 nTPM
Stomach	11.9 nTPM
Ovary	11.5 nTPM
Placenta	10.7 nTPM
Heart muscle	10.4 nTPM
Skin	7.0 nTPM
Esophagus	6.9 nTPM
Prostate	5.3 nTPM
Lung	3.4 nTPM

Intestinal goblet cells	8.4 nTPM
Colon	10.0 nTPM
Small intestine	8.3 nTPM
Rectum	7.0 nTPM

Macrophages	4.5 nTPM
Ovary	10.1 nTPM
Breast	8.0 nTPM
Skeletal muscle	6.5 nTPM
Adipose tissue	6.2 nTPM
Kidney	6.1 nTPM
Stomach	5.9 nTPM
Prostate	5.7 nTPM
Testis	5.2 nTPM
Spleen	4.2 nTPM
Esophagus	3.1 nTPM
Bone marrow	2.5 nTPM
Endometrium	2.0 nTPM
Lung	1.7 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM

Paneth cells	3.6 nTPM
Rectum	7.0 nTPM
Small intestine	3.7 nTPM
Colon	0.0 nTPM

Plasma cells	2.3 nTPM
Adipose tissue	10.3 nTPM
Spleen	0.6 nTPM
Stomach	0.4 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	7.0 nTPM
Bronchus	8.3 nTPM
Lung	5.8 nTPM

Smooth muscle cells	18.3 nTPM
Heart muscle	59.9 nTPM
Adipose tissue	34.0 nTPM
Breast	27.8 nTPM
Skeletal muscle	20.2 nTPM
Endometrium	12.6 nTPM
Prostate	11.9 nTPM
Ovary	9.5 nTPM
Pancreas	9.2 nTPM
Skin	8.4 nTPM
Esophagus	6.2 nTPM
Bronchus	1.9 nTPM

T-cells	4.4 nTPM
Adipose tissue	9.9 nTPM
Breast	8.0 nTPM
Esophagus	6.6 nTPM
Skeletal muscle	6.5 nTPM
Endometrium	6.3 nTPM
Prostate	4.7 nTPM
Ovary	4.5 nTPM
PBMC	4.4 nTPM
Liver	3.9 nTPM
Skin	3.6 nTPM
Kidney	3.4 nTPM
Lung	3.0 nTPM
Bone marrow	2.9 nTPM
Colon	2.4 nTPM
Stomach	2.3 nTPM
Spleen	1.6 nTPM
Lymph node	1.0 nTPM

Cholangiocytes	41.5 nTPM
Liver	41.5 nTPM

Collecting duct cells	11.0 nTPM
Kidney	11.0 nTPM

Cone photoreceptor cells	14.6 nTPM
Eye	14.6 nTPM

Cytotrophoblasts	0.9 nTPM
Placenta	0.9 nTPM

Undifferentiated cells	6.2 nTPM
Rectum	10.0 nTPM
Small intestine	4.8 nTPM
Colon	3.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC