Single cell type - CDK10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CDK10
Gene descriptionⁱ Full gene name according to HGNC.	Cyclin dependent kinase 10
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CDK10 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KIFC2	Kinesin family member C2	0.5814	53
D2HGDH	D-2-hydroxyglutarate dehydrogenase	0.5651	53
QTRT1	Queuine tRNA-ribosyltransferase catalytic subunit 1	0.5648	53
SPG7	SPG7 matrix AAA peptidase subunit, paraplegin	0.5615	52
CCDC14	Coiled-coil domain containing 14	0.5592	53
ADCK5	AarF domain containing kinase 5	0.5488	45
SLC10A5	Solute carrier family 10 member 5	0.5456	45
BRAT1	BRCA1 associated ATM activator 1	0.5308	52
TRMU	TRNA mitochondrial 2-thiouridylase	0.5285	52
TUBGCP6	Tubulin gamma complex associated protein 6	0.5266	52
GMDS	GDP-mannose 4,6-dehydratase	0.5250	27
FASTK	Fas activated serine/threonine kinase	0.5250	39
TAF1C	TATA-box binding protein associated factor, RNA polymerase I subunit C	0.5247	52
ABCC10	ATP binding cassette subfamily C member 10	0.5212	52
HDAC10	Histone deacetylase 10	0.5118	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	28.2 nTPM
Breast	32.3 nTPM
Adipose tissue	24.3 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	26.6 nTPM
Lung	26.6 nTPM

Astrocytes	35.3 nTPM
Brain	35.3 nTPM

B-cells	21.2 nTPM
Breast	32.1 nTPM
Kidney	28.5 nTPM
Bone marrow	27.0 nTPM
Stomach	21.8 nTPM
PBMC	21.4 nTPM
Colon	20.8 nTPM
Liver	20.7 nTPM
Spleen	16.0 nTPM
Lymph node	12.3 nTPM
Adipose tissue	11.5 nTPM

Dendritic cells	26.7 nTPM
Breast	39.3 nTPM
Adipose tissue	20.8 nTPM
PBMC	20.0 nTPM

Endothelial cells	23.0 nTPM
Placenta	37.5 nTPM
Ovary	30.6 nTPM
Heart muscle	29.5 nTPM
Breast	26.9 nTPM
Testis	26.4 nTPM
Prostate	25.7 nTPM
Endometrium	24.0 nTPM
Liver	20.2 nTPM
Esophagus	19.1 nTPM
Lung	18.7 nTPM
Skin	17.8 nTPM
Skeletal muscle	17.3 nTPM
Pancreas	15.5 nTPM
Eye	12.9 nTPM

Fibroblasts	19.6 nTPM
Ovary	37.9 nTPM
Placenta	29.2 nTPM
Breast	28.2 nTPM
Prostate	21.1 nTPM
Esophagus	17.6 nTPM
Adipose tissue	16.8 nTPM
Skin	16.2 nTPM
Heart muscle	14.4 nTPM
Skeletal muscle	14.1 nTPM
Stomach	13.4 nTPM
Lung	6.7 nTPM

Intestinal goblet cells	49.4 nTPM
Colon	61.5 nTPM
Small intestine	46.5 nTPM
Rectum	40.2 nTPM

Macrophages	17.0 nTPM
Bone marrow	25.0 nTPM
Breast	24.7 nTPM
Esophagus	23.6 nTPM
Stomach	20.5 nTPM
Ovary	20.4 nTPM
Spleen	19.7 nTPM
Lung	15.4 nTPM
Kidney	15.2 nTPM
Adipose tissue	14.7 nTPM
Prostate	13.8 nTPM
PBMC	13.6 nTPM
Pancreas	12.8 nTPM
Testis	12.2 nTPM
Endometrium	11.6 nTPM
Skeletal muscle	11.4 nTPM

Paneth cells	41.5 nTPM
Rectum	54.1 nTPM
Small intestine	37.6 nTPM
Colon	32.9 nTPM

Plasma cells	20.8 nTPM
Adipose tissue	28.5 nTPM
Bone marrow	24.7 nTPM
Stomach	21.4 nTPM
Spleen	17.3 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	28.1 nTPM
Bronchus	35.7 nTPM
Lung	20.4 nTPM

Smooth muscle cells	16.3 nTPM
Ovary	27.2 nTPM
Pancreas	26.8 nTPM
Breast	24.5 nTPM
Endometrium	19.9 nTPM
Prostate	18.5 nTPM
Skeletal muscle	13.4 nTPM
Adipose tissue	13.3 nTPM
Skin	11.9 nTPM
Bronchus	11.2 nTPM
Esophagus	7.8 nTPM
Heart muscle	5.5 nTPM

T-cells	22.0 nTPM
Breast	37.6 nTPM
Ovary	33.3 nTPM
Kidney	32.2 nTPM
Liver	31.2 nTPM
Colon	30.0 nTPM
Stomach	24.7 nTPM
PBMC	21.5 nTPM
Bone marrow	20.7 nTPM
Skeletal muscle	19.4 nTPM
Endometrium	19.0 nTPM
Spleen	18.9 nTPM
Lymph node	18.6 nTPM
Adipose tissue	17.5 nTPM
Lung	13.6 nTPM
Skin	13.3 nTPM
Esophagus	13.1 nTPM
Prostate	9.5 nTPM

Basal prostatic cells	24.2 nTPM
Prostate	24.2 nTPM

Basal squamous epithelial cells	23.3 nTPM
Esophagus	23.3 nTPM

Cholangiocytes	38.6 nTPM
Liver	38.6 nTPM

Collecting duct cells	27.6 nTPM
Kidney	27.6 nTPM

Undifferentiated cells	58.2 nTPM
Colon	69.4 nTPM
Small intestine	59.7 nTPM
Rectum	45.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC