Single cell type - BTN3A2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BTN3A2
Gene descriptionⁱ Full gene name according to HGNC.	Butyrophilin subfamily 3 member A2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (NK-cells, dendritic cells, T-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RPMI-8226)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (NK-cells, dendritic cells, T-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BTN3A2 is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ANXA2R	Annexin A2 receptor	0.8285	63
TBC1D10C	TBC1 domain family member 10C	0.8165	63
APOBEC3G	Apolipoprotein B mRNA editing enzyme catalytic subunit 3G	0.8085	63
TSPAN32	Tetraspanin 32	0.8050	63
IL12RB1	Interleukin 12 receptor subunit beta 1	0.7919	63
TRDC	T cell receptor delta constant	0.7898	63
BTN3A1	Butyrophilin subfamily 3 member A1	0.7765	63
TXK	TXK tyrosine kinase	0.7721	63
TRBC1	T cell receptor beta constant 1	0.7558	63
PTGDR	Prostaglandin D2 receptor	0.7544	63
GIMAP7	GTPase, IMAP family member 7	0.7527	63
CD160	CD160 molecule	0.7509	63
IFNL1	Interferon lambda 1	0.7453	63
TRAF3IP3	TRAF3 interacting protein 3	0.7419	63
IGKJ2	Immunoglobulin kappa joining 2	0.7379	63

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	62.5 nTPM
Breast	65.4 nTPM
Adipose tissue	59.6 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	22.2 nTPM
Lung	22.2 nTPM

Astrocytes	2.3 nTPM
Brain	2.3 nTPM

B-cells	61.3 nTPM
PBMC	119.9 nTPM
Liver	82.0 nTPM
Colon	73.5 nTPM
Bone marrow	69.5 nTPM
Breast	65.6 nTPM
Kidney	61.9 nTPM
Adipose tissue	42.6 nTPM
Spleen	38.7 nTPM
Lymph node	31.7 nTPM
Stomach	27.7 nTPM

Dendritic cells	117.2 nTPM
Breast	192.1 nTPM
Adipose tissue	127.7 nTPM
PBMC	31.8 nTPM

Endothelial cells	46.0 nTPM
Heart muscle	92.8 nTPM
Lung	90.5 nTPM
Liver	61.4 nTPM
Testis	54.5 nTPM
Skeletal muscle	49.2 nTPM
Breast	48.0 nTPM
Esophagus	46.5 nTPM
Ovary	45.5 nTPM
Prostate	33.5 nTPM
Endometrium	32.8 nTPM
Eye	29.9 nTPM
Skin	25.9 nTPM
Placenta	25.6 nTPM
Pancreas	7.7 nTPM

Fibroblasts	20.2 nTPM
Breast	26.2 nTPM
Skeletal muscle	24.9 nTPM
Heart muscle	24.8 nTPM
Lung	22.4 nTPM
Esophagus	21.8 nTPM
Ovary	20.8 nTPM
Placenta	19.7 nTPM
Adipose tissue	19.1 nTPM
Stomach	17.8 nTPM
Prostate	12.9 nTPM
Skin	12.2 nTPM

Intestinal goblet cells	37.9 nTPM
Small intestine	60.3 nTPM
Colon	34.3 nTPM
Rectum	19.0 nTPM

Macrophages	37.1 nTPM
PBMC	163.7 nTPM
Lung	53.5 nTPM
Breast	48.5 nTPM
Bone marrow	47.5 nTPM
Ovary	37.1 nTPM
Kidney	32.5 nTPM
Testis	29.1 nTPM
Spleen	27.0 nTPM
Endometrium	24.3 nTPM
Skeletal muscle	23.7 nTPM
Adipose tissue	20.7 nTPM
Prostate	15.0 nTPM
Stomach	14.7 nTPM
Esophagus	14.2 nTPM
Pancreas	5.1 nTPM

Paneth cells	16.9 nTPM
Small intestine	18.8 nTPM
Rectum	18.6 nTPM
Colon	13.2 nTPM

Plasma cells	76.6 nTPM
Adipose tissue	90.4 nTPM
Stomach	81.8 nTPM
Spleen	76.3 nTPM
Bone marrow	72.5 nTPM
Esophagus	61.7 nTPM

Respiratory ciliated cells	11.8 nTPM
Bronchus	11.8 nTPM
Lung	11.7 nTPM

Smooth muscle cells	10.2 nTPM
Breast	21.3 nTPM
Endometrium	20.1 nTPM
Ovary	18.7 nTPM
Skeletal muscle	12.3 nTPM
Adipose tissue	9.5 nTPM
Prostate	8.8 nTPM
Heart muscle	6.6 nTPM
Skin	5.9 nTPM
Esophagus	4.6 nTPM
Pancreas	4.1 nTPM
Bronchus	0.9 nTPM

T-cells	108.0 nTPM
PBMC	218.2 nTPM
Liver	172.3 nTPM
Ovary	164.6 nTPM
Lung	142.8 nTPM
Kidney	134.1 nTPM
Breast	128.5 nTPM
Skeletal muscle	124.7 nTPM
Bone marrow	120.2 nTPM
Colon	116.4 nTPM
Spleen	101.1 nTPM
Adipose tissue	87.4 nTPM
Lymph node	64.3 nTPM
Endometrium	64.0 nTPM
Prostate	61.6 nTPM
Esophagus	52.4 nTPM
Stomach	49.5 nTPM
Skin	34.0 nTPM

Basal keratinocytes	10.3 nTPM
Skin	10.3 nTPM

Basal respiratory cells	8.6 nTPM
Bronchus	8.6 nTPM

Basal squamous epithelial cells	13.1 nTPM
Esophagus	13.1 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Undifferentiated cells	25.5 nTPM
Small intestine	44.4 nTPM
Colon	20.8 nTPM
Rectum	11.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC