Single cell type - HEXIM1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HEXIM1
Gene descriptionⁱ Full gene name according to HGNC.	HEXIM P-TEFb complex subunit 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Mitochondria (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

HEXIM1 is part of cluster 7 Non-specific - Mitochondria with confidenceⁱ 1
481 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NXF1	Nuclear RNA export factor 1	0.8308	7
SERTAD1	SERTA domain containing 1	0.7759	7
BRD2	Bromodomain containing 2	0.7720	7
PPP1R10	Protein phosphatase 1 regulatory subunit 10	0.7519	7
DDIT3	DNA damage inducible transcript 3	0.7467	7
IFRD1	Interferon related developmental regulator 1	0.7421	7
INTS6	Integrator complex subunit 6	0.7420	7
IER2	Immediate early response 2	0.7331	7
RSRP1	Arginine and serine rich protein 1	0.7308	7
YME1L1	YME1 like 1 ATPase	0.7001	7
PLK3	Polo like kinase 3	0.6895	7
GADD45B	Growth arrest and DNA damage inducible beta	0.6892	7
SLC9A1	Solute carrier family 9 member A1	0.6865	53
NUFIP2	Nuclear FMR1 interacting protein 2	0.6820	7
MYLIP	Myosin regulatory light chain interacting protein	0.6771	7

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	210.3 nTPM
Breast	310.6 nTPM
Adipose tissue	109.9 nTPM

Alveolar cells type 1	73.7 nTPM
Lung	73.7 nTPM

Alveolar cells type 2	111.8 nTPM
Lung	111.8 nTPM

Astrocytes	7.2 nTPM
Brain	7.2 nTPM

B-cells	76.1 nTPM
Lymph node	255.8 nTPM
Breast	211.4 nTPM
Adipose tissue	77.7 nTPM
Colon	52.7 nTPM
Stomach	45.0 nTPM
Spleen	37.4 nTPM
Liver	30.0 nTPM
Kidney	28.5 nTPM
PBMC	14.3 nTPM
Bone marrow	8.1 nTPM

Basal squamous epithelial cells	157.1 nTPM
Esophagus	157.1 nTPM

Dendritic cells	114.3 nTPM
Breast	218.0 nTPM
Adipose tissue	96.9 nTPM
PBMC	27.9 nTPM

Endothelial cells	91.3 nTPM
Breast	254.9 nTPM
Esophagus	249.2 nTPM
Skeletal muscle	186.9 nTPM
Eye	101.2 nTPM
Skin	94.9 nTPM
Prostate	88.3 nTPM
Endometrium	62.4 nTPM
Placenta	50.6 nTPM
Liver	45.8 nTPM
Heart muscle	41.1 nTPM
Lung	31.2 nTPM
Ovary	27.1 nTPM
Testis	24.9 nTPM
Pancreas	19.3 nTPM

Fibroblasts	99.2 nTPM
Esophagus	337.4 nTPM
Breast	187.6 nTPM
Skeletal muscle	109.4 nTPM
Prostate	107.4 nTPM
Skin	102.8 nTPM
Stomach	62.4 nTPM
Placenta	52.2 nTPM
Heart muscle	47.3 nTPM
Lung	45.8 nTPM
Adipose tissue	26.7 nTPM
Ovary	12.1 nTPM

Intestinal goblet cells	122.0 nTPM
Colon	234.4 nTPM
Small intestine	76.2 nTPM
Rectum	55.2 nTPM

Macrophages	83.0 nTPM
Breast	267.1 nTPM
Esophagus	185.7 nTPM
Lung	119.3 nTPM
Adipose tissue	119.2 nTPM
Skeletal muscle	115.9 nTPM
Endometrium	96.7 nTPM
PBMC	68.2 nTPM
Stomach	64.5 nTPM
Prostate	45.8 nTPM
Spleen	45.6 nTPM
Kidney	34.0 nTPM
Ovary	33.3 nTPM
Testis	21.5 nTPM
Bone marrow	17.5 nTPM
Pancreas	10.2 nTPM

Paneth cells	127.1 nTPM
Colon	220.7 nTPM
Small intestine	116.4 nTPM
Rectum	44.3 nTPM

Plasma cells	44.1 nTPM
Adipose tissue	111.0 nTPM
Esophagus	43.0 nTPM
Stomach	42.0 nTPM
Spleen	17.9 nTPM
Bone marrow	6.6 nTPM

Respiratory ciliated cells	45.7 nTPM
Bronchus	46.1 nTPM
Lung	45.2 nTPM

Smooth muscle cells	128.2 nTPM
Esophagus	302.4 nTPM
Breast	272.7 nTPM
Skeletal muscle	233.3 nTPM
Skin	168.8 nTPM
Adipose tissue	107.8 nTPM
Endometrium	85.5 nTPM
Prostate	85.3 nTPM
Bronchus	67.5 nTPM
Heart muscle	46.1 nTPM
Ovary	22.9 nTPM
Pancreas	17.9 nTPM

Cholangiocytes	87.2 nTPM
Liver	87.2 nTPM

Collecting duct cells	25.8 nTPM
Kidney	25.8 nTPM

Cytotrophoblasts	134.8 nTPM
Placenta	134.8 nTPM

Distal enterocytes	250.4 nTPM
Colon	382.8 nTPM
Rectum	118.1 nTPM

T-cells	111.1 nTPM
Breast	289.2 nTPM
Lymph node	244.7 nTPM
Endometrium	193.7 nTPM
Skeletal muscle	179.1 nTPM
Lung	139.8 nTPM
Adipose tissue	125.6 nTPM
Esophagus	124.5 nTPM
Colon	111.7 nTPM
Skin	106.4 nTPM
Ovary	75.7 nTPM
Spleen	68.1 nTPM
Liver	59.3 nTPM
Prostate	47.3 nTPM
Kidney	43.1 nTPM
Stomach	43.1 nTPM
PBMC	22.4 nTPM
Bone marrow	15.8 nTPM

Undifferentiated cells	92.2 nTPM
Colon	169.8 nTPM
Small intestine	53.8 nTPM
Rectum	53.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC