Single cell type - NAP1L1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NAP1L1
Gene descriptionⁱ Full gene name according to HGNC.	Nucleosome assembly protein 1 like 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	18

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Translation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NAP1L1 is part of cluster 32 Non-specific - Translation with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RPS11	Ribosomal protein S11	0.6385	32
RPL23	Ribosomal protein L23	0.6207	32
RPL27	Ribosomal protein L27	0.6027	32
RPS20	Ribosomal protein S20	0.5784	32
EIF3M	Eukaryotic translation initiation factor 3 subunit M	0.5760	10
EIF3E	Eukaryotic translation initiation factor 3 subunit E	0.5714	32
RPS16	Ribosomal protein S16	0.5676	32
RPS3A	Ribosomal protein S3A	0.5649	32
RPL23A	Ribosomal protein L23a	0.5489	32
MTPN	Myotrophin	0.5454	51
RPL9	Ribosomal protein L9	0.5447	32
RGS10	Regulator of G protein signaling 10	0.5425	51
RPS23	Ribosomal protein S23	0.5394	32
NACA	Nascent polypeptide associated complex subunit alpha	0.5388	32
RPL18A	Ribosomal protein L18a	0.5377	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	184.6 nTPM
Adipose tissue	211.6 nTPM
Breast	157.6 nTPM

Alveolar cells type 1	166.7 nTPM
Lung	166.7 nTPM

Alveolar cells type 2	227.5 nTPM
Lung	227.5 nTPM

Astrocytes	77.4 nTPM
Brain	77.4 nTPM

B-cells	506.6 nTPM
PBMC	992.1 nTPM
Adipose tissue	901.8 nTPM
Colon	599.0 nTPM
Kidney	595.1 nTPM
Liver	445.0 nTPM
Spleen	369.7 nTPM
Bone marrow	344.2 nTPM
Lymph node	304.8 nTPM
Stomach	262.5 nTPM
Breast	251.4 nTPM

Basal squamous epithelial cells	352.3 nTPM
Esophagus	352.3 nTPM

Dendritic cells	313.5 nTPM
PBMC	450.3 nTPM
Adipose tissue	312.7 nTPM
Breast	177.5 nTPM

Endothelial cells	340.2 nTPM
Prostate	679.2 nTPM
Testis	617.8 nTPM
Skin	418.3 nTPM
Endometrium	394.7 nTPM
Placenta	374.0 nTPM
Lung	343.1 nTPM
Pancreas	324.3 nTPM
Liver	299.9 nTPM
Breast	272.1 nTPM
Ovary	270.4 nTPM
Esophagus	218.2 nTPM
Skeletal muscle	218.0 nTPM
Eye	203.9 nTPM
Heart muscle	128.6 nTPM

Enteroendocrine cells	247.1 nTPM
Colon	280.7 nTPM
Rectum	213.6 nTPM

Erythroid cells	254.9 nTPM
Bone marrow	311.9 nTPM
Liver	197.9 nTPM

Fibroblasts	386.6 nTPM
Prostate	1024.8 nTPM
Lung	720.5 nTPM
Placenta	468.6 nTPM
Ovary	392.1 nTPM
Skin	373.1 nTPM
Heart muscle	271.7 nTPM
Adipose tissue	245.5 nTPM
Breast	221.2 nTPM
Skeletal muscle	218.0 nTPM
Esophagus	177.5 nTPM
Stomach	139.6 nTPM

Intestinal goblet cells	160.6 nTPM
Colon	203.7 nTPM
Rectum	162.7 nTPM
Small intestine	115.4 nTPM

Macrophages	644.0 nTPM
PBMC	2550.8 nTPM
Adipose tissue	1034.4 nTPM
Prostate	897.6 nTPM
Kidney	701.0 nTPM
Testis	650.1 nTPM
Lung	588.3 nTPM
Endometrium	569.6 nTPM
Skeletal muscle	524.5 nTPM
Bone marrow	462.3 nTPM
Spleen	371.2 nTPM
Breast	338.4 nTPM
Esophagus	281.7 nTPM
Stomach	278.3 nTPM
Ovary	257.8 nTPM
Pancreas	153.2 nTPM

Paneth cells	61.3 nTPM
Rectum	104.2 nTPM
Small intestine	60.1 nTPM
Colon	19.7 nTPM

Plasma cells	183.4 nTPM
Adipose tissue	292.2 nTPM
Spleen	229.2 nTPM
Bone marrow	210.9 nTPM
Stomach	123.0 nTPM
Esophagus	61.7 nTPM

Cholangiocytes	197.3 nTPM
Liver	197.3 nTPM

Collecting duct cells	136.1 nTPM
Kidney	136.1 nTPM

Cone photoreceptor cells	79.2 nTPM
Eye	79.2 nTPM

Cytotrophoblasts	523.7 nTPM
Placenta	523.7 nTPM

Respiratory ciliated cells	341.6 nTPM
Bronchus	358.2 nTPM
Lung	325.0 nTPM

Smooth muscle cells	448.4 nTPM
Bronchus	972.5 nTPM
Prostate	835.5 nTPM
Endometrium	541.9 nTPM
Skin	461.3 nTPM
Pancreas	445.0 nTPM
Skeletal muscle	366.6 nTPM
Ovary	350.5 nTPM
Adipose tissue	348.4 nTPM
Breast	240.7 nTPM
Esophagus	210.9 nTPM
Heart muscle	159.7 nTPM

T-cells	408.4 nTPM
PBMC	1029.2 nTPM
Adipose tissue	643.5 nTPM
Prostate	605.9 nTPM
Colon	546.0 nTPM
Skin	502.9 nTPM
Skeletal muscle	397.2 nTPM
Liver	373.0 nTPM
Lung	356.9 nTPM
Kidney	355.9 nTPM
Endometrium	346.9 nTPM
Lymph node	329.4 nTPM
Esophagus	301.4 nTPM
Breast	298.7 nTPM
Spleen	269.0 nTPM
Stomach	219.4 nTPM
Bone marrow	196.8 nTPM
Ovary	171.3 nTPM

Undifferentiated cells	182.9 nTPM
Small intestine	232.9 nTPM
Colon	177.0 nTPM
Rectum	138.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC