Single cell type - FSIP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FSIP2
Gene descriptionⁱ Full gene name according to HGNC.	Fibrous sheath interacting protein 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Flagellum & Golgi organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids, Alveolar cells type 1, Spermatocytes, Alveolar cells type 2, Gastric mucus-secreting cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in single
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids, Alveolar cells type 1, Spermatocytes, Alveolar cells type 2, Gastric mucus-secreting cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FSIP2 is part of cluster 23 Spermatids - Flagellum & Golgi organization with confidenceⁱ 1
311 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CFAP206	Cilia and flagella associated protein 206	0.7617	23
CCDC173	Coiled-coil domain containing 173	0.7613	23
CDRT15L2	CMT1A duplicated region transcript 15 like 2	0.7316	23
GOLGA8S	Golgin A8 family member S	0.7015	23
C12orf71	Chromosome 12 open reading frame 71	0.6929	23
USP44	Ubiquitin specific peptidase 44	0.6905	23
NKAPL	NFKB activating protein like	0.6884	66
TGIF2LY	TGFB induced factor homeobox 2 like Y-linked	0.6758	23
SPDYE4	Speedy/RINGO cell cycle regulator family member E4	0.6740	23
LCA5L	Lebercilin LCA5 like	0.6648	66
CTAGE1	Cutaneous T cell lymphoma-associated antigen 1	0.6645	23
FAM24A	Family with sequence similarity 24 member A	0.6626	23
GOLGA6L2	Golgin A6 family like 2	0.6604	23
SSMEM1	Serine rich single-pass membrane protein 1	0.6519	23
NCBP2L	Nuclear cap binding protein subunit 2 like	0.6513	23

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	1.7 nTPM
Adipose tissue	2.0 nTPM
Breast	1.3 nTPM

Astrocytes	5.2 nTPM
Brain	5.2 nTPM

B-cells	2.6 nTPM
Kidney	14.3 nTPM
PBMC	5.7 nTPM
Adipose tissue	3.0 nTPM
Colon	1.6 nTPM
Stomach	1.4 nTPM
Liver	0.4 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Breast	0.0 nTPM

Basal keratinocytes	0.5 nTPM
Skin	0.5 nTPM

Basal prostatic cells	0.1 nTPM
Prostate	0.1 nTPM

Dendritic cells	1.0 nTPM
Adipose tissue	2.6 nTPM
Breast	0.4 nTPM
PBMC	0.0 nTPM

Endothelial cells	5.6 nTPM
Lung	62.4 nTPM
Heart muscle	3.7 nTPM
Testis	3.0 nTPM
Endometrium	2.5 nTPM
Ovary	2.1 nTPM
Skeletal muscle	1.8 nTPM
Breast	1.2 nTPM
Skin	0.7 nTPM
Placenta	0.6 nTPM
Esophagus	0.6 nTPM
Prostate	0.1 nTPM
Eye	0.0 nTPM
Liver	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	7.3 nTPM
Lung	63.7 nTPM
Skeletal muscle	4.0 nTPM
Breast	3.4 nTPM
Heart muscle	2.2 nTPM
Adipose tissue	2.2 nTPM
Stomach	1.5 nTPM
Skin	1.1 nTPM
Esophagus	1.1 nTPM
Ovary	0.9 nTPM
Placenta	0.5 nTPM
Prostate	0.2 nTPM

Intestinal goblet cells	19.7 nTPM
Colon	32.2 nTPM
Small intestine	20.0 nTPM
Rectum	6.9 nTPM

Macrophages	5.9 nTPM
Lung	75.5 nTPM
Testis	7.5 nTPM
Kidney	1.5 nTPM
Bone marrow	1.2 nTPM
Adipose tissue	0.9 nTPM
Skeletal muscle	0.8 nTPM
Breast	0.7 nTPM
Endometrium	0.6 nTPM
Ovary	0.2 nTPM
Prostate	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	5.5 nTPM
Colon	16.5 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	1.3 nTPM
Bone marrow	3.3 nTPM
Adipose tissue	2.7 nTPM
Stomach	0.4 nTPM
Esophagus	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	46.0 nTPM
Lung	90.3 nTPM
Bronchus	1.7 nTPM

Smooth muscle cells	0.8 nTPM
Endometrium	2.0 nTPM
Adipose tissue	1.6 nTPM
Heart muscle	1.5 nTPM
Ovary	1.3 nTPM
Skin	0.7 nTPM
Breast	0.7 nTPM
Prostate	0.6 nTPM
Skeletal muscle	0.5 nTPM
Pancreas	0.2 nTPM
Bronchus	0.0 nTPM
Esophagus	0.0 nTPM

T-cells	6.0 nTPM
Lung	88.1 nTPM
Colon	2.9 nTPM
PBMC	2.9 nTPM
Adipose tissue	2.1 nTPM
Endometrium	1.9 nTPM
Liver	1.2 nTPM
Breast	1.2 nTPM
Stomach	1.1 nTPM
Bone marrow	0.4 nTPM
Kidney	0.0 nTPM
Prostate	0.0 nTPM
Skin	0.0 nTPM
Skeletal muscle	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Spleen	0.0 nTPM

Cone photoreceptor cells	10.4 nTPM
Eye	10.4 nTPM

Cytotrophoblasts	0.3 nTPM
Placenta	0.3 nTPM

Early spermatids	289.6 nTPM
Testis	289.6 nTPM

Excitatory neurons	4.5 nTPM
Brain	4.5 nTPM

Undifferentiated cells	5.2 nTPM
Colon	14.5 nTPM
Rectum	0.7 nTPM
Small intestine	0.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC