Single cell type - FAM120AOS - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM120AOS
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 120A opposite strand
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Syncytiotrophoblasts - Pregnancy hormone signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts, Extravillous trophoblasts)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts, Extravillous trophoblasts)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FAM120AOS is part of cluster 18 Syncytiotrophoblasts - Pregnancy hormone signaling with confidenceⁱ 1
186 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DLX3	Distal-less homeobox 3	0.7211	38
GCM1	Glial cells missing transcription factor 1	0.7087	38
MAP11	Microtubule associated protein 11	0.6845	18
GATA3	GATA binding protein 3	0.6816	18
GH2	Growth hormone 2	0.6788	18
SLC49A4	Solute carrier family 49 member 4	0.6734	18
HSD3B1	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	0.6734	18
CSH1	Chorionic somatomammotropin hormone 1	0.6732	18
CDKN1C	Cyclin dependent kinase inhibitor 1C	0.6726	18
TINCR	TINCR ubiquitin domain containing	0.6724	18
AKR1B1	Aldo-keto reductase family 1 member B	0.6653	38
XAGE2	X antigen family member 2	0.6632	38
PHLDA2	Pleckstrin homology like domain family A member 2	0.6595	18
CGB5	Chorionic gonadotropin subunit beta 5	0.6595	18
LEP	Leptin	0.6591	18

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	29.8 nTPM
Breast	34.3 nTPM
Adipose tissue	25.4 nTPM

Alveolar cells type 1	35.3 nTPM
Lung	35.3 nTPM

Alveolar cells type 2	45.4 nTPM
Lung	45.4 nTPM

Astrocytes	22.2 nTPM
Brain	22.2 nTPM

B-cells	30.8 nTPM
Stomach	50.4 nTPM
Lymph node	42.9 nTPM
Spleen	35.7 nTPM
Colon	33.5 nTPM
Bone marrow	30.2 nTPM
Liver	28.3 nTPM
Adipose tissue	26.6 nTPM
Kidney	23.8 nTPM
PBMC	21.4 nTPM
Breast	14.7 nTPM

Dendritic cells	25.8 nTPM
Adipose tissue	34.4 nTPM
Breast	27.0 nTPM
PBMC	16.0 nTPM

Endothelial cells	28.4 nTPM
Eye	50.2 nTPM
Pancreas	38.6 nTPM
Esophagus	38.1 nTPM
Lung	37.4 nTPM
Heart muscle	31.3 nTPM
Endometrium	30.0 nTPM
Breast	27.9 nTPM
Placenta	23.3 nTPM
Skeletal muscle	21.3 nTPM
Liver	21.1 nTPM
Ovary	20.9 nTPM
Testis	19.8 nTPM
Skin	18.8 nTPM
Prostate	18.4 nTPM

Fibroblasts	37.3 nTPM
Esophagus	57.1 nTPM
Stomach	50.5 nTPM
Heart muscle	43.3 nTPM
Lung	40.2 nTPM
Adipose tissue	38.4 nTPM
Breast	37.5 nTPM
Skeletal muscle	36.4 nTPM
Placenta	30.2 nTPM
Skin	29.6 nTPM
Prostate	26.6 nTPM
Ovary	20.2 nTPM

Intestinal goblet cells	42.8 nTPM
Colon	62.2 nTPM
Rectum	38.2 nTPM
Small intestine	27.9 nTPM

Macrophages	29.7 nTPM
Lung	53.2 nTPM
Prostate	51.6 nTPM
Stomach	35.1 nTPM
Breast	34.7 nTPM
Ovary	33.4 nTPM
Endometrium	32.4 nTPM
Adipose tissue	29.8 nTPM
Esophagus	26.8 nTPM
Bone marrow	26.2 nTPM
Testis	24.4 nTPM
Skeletal muscle	24.1 nTPM
Spleen	22.8 nTPM
Kidney	19.6 nTPM
Pancreas	17.8 nTPM
PBMC	13.6 nTPM

Paneth cells	41.0 nTPM
Colon	62.6 nTPM
Rectum	34.2 nTPM
Small intestine	26.3 nTPM

Plasma cells	37.0 nTPM
Stomach	47.1 nTPM
Spleen	46.9 nTPM
Bone marrow	34.6 nTPM
Esophagus	30.7 nTPM
Adipose tissue	25.8 nTPM

Respiratory ciliated cells	24.7 nTPM
Lung	37.9 nTPM
Bronchus	11.5 nTPM

Smooth muscle cells	36.0 nTPM
Esophagus	57.4 nTPM
Heart muscle	52.5 nTPM
Prostate	45.4 nTPM
Breast	45.0 nTPM
Adipose tissue	35.1 nTPM
Pancreas	34.5 nTPM
Skeletal muscle	31.9 nTPM
Skin	28.6 nTPM
Endometrium	27.4 nTPM
Ovary	24.8 nTPM
Bronchus	13.0 nTPM

T-cells	30.6 nTPM
Stomach	49.5 nTPM
Esophagus	45.9 nTPM
Lung	41.0 nTPM
Adipose tissue	40.9 nTPM
Lymph node	38.2 nTPM
Spleen	35.0 nTPM
Breast	34.5 nTPM
Endometrium	33.2 nTPM
Bone marrow	30.5 nTPM
Liver	29.1 nTPM
Colon	26.1 nTPM
PBMC	24.8 nTPM
Ovary	22.3 nTPM
Kidney	20.5 nTPM
Skin	18.0 nTPM
Skeletal muscle	16.9 nTPM
Prostate	14.2 nTPM

Basal keratinocytes	12.6 nTPM
Skin	12.6 nTPM

Basal prostatic cells	45.8 nTPM
Prostate	45.8 nTPM

Basal respiratory cells	21.6 nTPM
Bronchus	21.6 nTPM

Basal squamous epithelial cells	40.5 nTPM
Esophagus	40.5 nTPM

Undifferentiated cells	30.6 nTPM
Colon	39.9 nTPM
Rectum	33.3 nTPM
Small intestine	18.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC