Single cell type - ALKBH2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ALKBH2
Gene descriptionⁱ Full gene name according to HGNC.	AlkB homolog 2, alpha-ketoglutarate dependent dioxygenase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ALKBH2 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.99
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MYC	MYC proto-oncogene, bHLH transcription factor	0.7248	61
NOP16	NOP16 nucleolar protein	0.6470	39
NIFK	Nucleolar protein interacting with the FHA domain of MKI67	0.6350	39
NR2C2AP	Nuclear receptor 2C2 associated protein	0.6011	32
SNAI2	Snail family transcriptional repressor 2	0.5868	48
PPAN	Peter pan homolog	0.5751	39
DPH2	Diphthamide biosynthesis 2	0.5694	39
ERF	ETS2 repressor factor	0.5587	35
GPATCH4	G-patch domain containing 4	0.5568	39
PHF13	PHD finger protein 13	0.5565	61
NXT1	Nuclear transport factor 2 like export factor 1	0.5560	28
RSL1D1	Ribosomal L1 domain containing 1	0.5558	32
NOB1	NIN1 (RPN12) binding protein 1 homolog	0.5481	32
NTF3	Neurotrophin 3	0.5459	22
PAK1IP1	PAK1 interacting protein 1	0.5376	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	23.7 nTPM
Breast	24.7 nTPM
Adipose tissue	22.8 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	6.3 nTPM
Lung	6.3 nTPM

Astrocytes	4.2 nTPM
Brain	4.2 nTPM

B-cells	15.9 nTPM
Lymph node	31.2 nTPM
Spleen	23.9 nTPM
Liver	20.6 nTPM
Bone marrow	15.5 nTPM
Kidney	14.3 nTPM
PBMC	12.9 nTPM
Stomach	11.8 nTPM
Colon	11.2 nTPM
Breast	10.7 nTPM
Adipose tissue	6.6 nTPM

Dendritic cells	12.5 nTPM
Breast	15.3 nTPM
PBMC	12.0 nTPM
Adipose tissue	10.2 nTPM

Endothelial cells	17.3 nTPM
Skin	36.9 nTPM
Esophagus	30.0 nTPM
Prostate	23.5 nTPM
Lung	21.8 nTPM
Breast	21.3 nTPM
Skeletal muscle	18.6 nTPM
Testis	14.5 nTPM
Ovary	13.5 nTPM
Heart muscle	12.5 nTPM
Liver	11.9 nTPM
Placenta	11.9 nTPM
Pancreas	11.6 nTPM
Endometrium	8.2 nTPM
Eye	6.5 nTPM

Fibroblasts	20.6 nTPM
Breast	25.5 nTPM
Prostate	25.3 nTPM
Ovary	24.4 nTPM
Skin	24.2 nTPM
Adipose tissue	23.4 nTPM
Skeletal muscle	19.9 nTPM
Placenta	18.1 nTPM
Stomach	17.8 nTPM
Heart muscle	17.5 nTPM
Esophagus	17.3 nTPM
Lung	13.4 nTPM

Intestinal goblet cells	11.6 nTPM
Small intestine	13.6 nTPM
Rectum	12.6 nTPM
Colon	8.5 nTPM

Macrophages	6.8 nTPM
Esophagus	14.2 nTPM
Breast	13.1 nTPM
Pancreas	10.2 nTPM
Kidney	9.1 nTPM
Bone marrow	8.7 nTPM
Testis	8.1 nTPM
Endometrium	7.5 nTPM
Spleen	6.2 nTPM
Skeletal muscle	6.0 nTPM
Adipose tissue	5.8 nTPM
Ovary	5.3 nTPM
Lung	3.6 nTPM
Prostate	3.4 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	5.1 nTPM
Rectum	11.9 nTPM
Colon	3.3 nTPM
Small intestine	0.0 nTPM

Plasma cells	13.1 nTPM
Spleen	21.4 nTPM
Stomach	15.8 nTPM
Esophagus	12.3 nTPM
Bone marrow	11.5 nTPM
Adipose tissue	4.5 nTPM

Respiratory ciliated cells	10.0 nTPM
Lung	14.6 nTPM
Bronchus	5.5 nTPM

Smooth muscle cells	26.0 nTPM
Skin	58.3 nTPM
Prostate	42.2 nTPM
Breast	32.0 nTPM
Esophagus	27.9 nTPM
Skeletal muscle	27.7 nTPM
Adipose tissue	21.7 nTPM
Pancreas	20.3 nTPM
Endometrium	19.7 nTPM
Ovary	17.3 nTPM
Heart muscle	16.8 nTPM
Bronchus	1.9 nTPM

T-cells	12.6 nTPM
Lymph node	26.0 nTPM
PBMC	17.8 nTPM
Breast	15.7 nTPM
Bone marrow	15.0 nTPM
Prostate	14.2 nTPM
Skin	13.3 nTPM
Kidney	13.1 nTPM
Esophagus	13.1 nTPM
Liver	12.8 nTPM
Spleen	12.7 nTPM
Lung	12.2 nTPM
Colon	10.9 nTPM
Endometrium	10.4 nTPM
Stomach	10.2 nTPM
Skeletal muscle	8.0 nTPM
Adipose tissue	7.0 nTPM
Ovary	2.2 nTPM

Basal keratinocytes	50.9 nTPM
Skin	50.9 nTPM

Basal prostatic cells	52.2 nTPM
Prostate	52.2 nTPM

Basal respiratory cells	19.4 nTPM
Bronchus	19.4 nTPM

Basal squamous epithelial cells	42.1 nTPM
Esophagus	42.1 nTPM

Undifferentiated cells	14.8 nTPM
Small intestine	22.3 nTPM
Rectum	14.2 nTPM
Colon	7.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC