Single cell type - ZBTB44 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZBTB44
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger and BTB domain containing 44
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Endometrium - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZBTB44 is part of cluster 44 Endometrium - Transcription with confidenceⁱ 1
491 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZNF652	Zinc finger protein 652	0.5221	52
ZNF592	Zinc finger protein 592	0.4667	44
EPG5	Ectopic P-granules autophagy protein 5 homolog	0.4637	63
RC3H1	Ring finger and CCCH-type domains 1	0.4598	44
CNOT6	CCR4-NOT transcription complex subunit 6	0.4532	52
PUM1	Pumilio RNA binding family member 1	0.4465	44
PHF8	PHD finger protein 8	0.4445	20
NUP153	Nucleoporin 153	0.4410	44
OR2A12	Olfactory receptor family 2 subfamily A member 12	0.4354	44
TBL1XR1	TBL1X receptor 1	0.4349	44
FBXO21	F-box protein 21	0.4295	44
FOXK1	Forkhead box K1	0.4274	25
CNKSR3	CNKSR family member 3	0.4242	44
TAF8	TATA-box binding protein associated factor 8	0.4237	44
AMOTL2	Angiomotin like 2	0.4199	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	32.6 nTPM
Adipose tissue	38.8 nTPM
Breast	26.4 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	39.4 nTPM
Lung	39.4 nTPM

Astrocytes	33.0 nTPM
Brain	33.0 nTPM

B-cells	42.9 nTPM
Adipose tissue	66.7 nTPM
Spleen	52.9 nTPM
PBMC	48.5 nTPM
Lymph node	46.6 nTPM
Bone marrow	46.6 nTPM
Kidney	42.9 nTPM
Colon	41.5 nTPM
Stomach	35.4 nTPM
Liver	24.7 nTPM
Breast	22.8 nTPM

Dendritic cells	61.6 nTPM
Adipose tissue	88.0 nTPM
Breast	60.9 nTPM
PBMC	35.8 nTPM

Endothelial cells	33.8 nTPM
Liver	47.7 nTPM
Testis	47.7 nTPM
Skin	45.3 nTPM
Prostate	42.5 nTPM
Breast	41.7 nTPM
Endometrium	35.1 nTPM
Esophagus	31.4 nTPM
Skeletal muscle	31.1 nTPM
Heart muscle	30.8 nTPM
Ovary	30.6 nTPM
Eye	28.3 nTPM
Lung	24.9 nTPM
Placenta	24.5 nTPM
Pancreas	11.6 nTPM

Fibroblasts	40.2 nTPM
Skin	55.4 nTPM
Breast	53.8 nTPM
Esophagus	53.1 nTPM
Adipose tissue	47.4 nTPM
Prostate	44.7 nTPM
Skeletal muscle	41.1 nTPM
Heart muscle	40.7 nTPM
Ovary	38.5 nTPM
Placenta	27.7 nTPM
Stomach	22.3 nTPM
Lung	17.9 nTPM

Intestinal goblet cells	26.8 nTPM
Rectum	37.2 nTPM
Small intestine	26.5 nTPM
Colon	16.5 nTPM

Macrophages	30.0 nTPM
Testis	51.2 nTPM
Bone marrow	41.2 nTPM
Skeletal muscle	40.4 nTPM
Ovary	37.8 nTPM
Esophagus	37.7 nTPM
Spleen	37.4 nTPM
Kidney	36.3 nTPM
Adipose tissue	34.6 nTPM
Stomach	29.4 nTPM
Prostate	27.5 nTPM
Lung	23.3 nTPM
Breast	21.7 nTPM
Endometrium	16.4 nTPM
Pancreas	15.3 nTPM
PBMC	0.0 nTPM

Paneth cells	16.9 nTPM
Rectum	26.4 nTPM
Colon	13.2 nTPM
Small intestine	11.3 nTPM

Plasma cells	27.1 nTPM
Adipose tissue	60.0 nTPM
Esophagus	24.6 nTPM
Stomach	22.4 nTPM
Spleen	15.5 nTPM
Bone marrow	13.2 nTPM

Respiratory ciliated cells	30.5 nTPM
Bronchus	42.0 nTPM
Lung	19.0 nTPM

Smooth muscle cells	26.5 nTPM
Esophagus	43.4 nTPM
Adipose tissue	40.1 nTPM
Skin	34.5 nTPM
Prostate	32.5 nTPM
Ovary	32.1 nTPM
Skeletal muscle	31.5 nTPM
Endometrium	22.9 nTPM
Breast	21.3 nTPM
Heart muscle	13.8 nTPM
Bronchus	11.4 nTPM
Pancreas	8.2 nTPM

T-cells	40.2 nTPM
Liver	61.6 nTPM
Skeletal muscle	61.2 nTPM
Adipose tissue	57.6 nTPM
Colon	57.0 nTPM
PBMC	53.0 nTPM
Kidney	41.1 nTPM
Lymph node	39.9 nTPM
Spleen	39.6 nTPM
Bone marrow	39.3 nTPM
Prostate	37.9 nTPM
Breast	36.5 nTPM
Endometrium	32.2 nTPM
Skin	28.1 nTPM
Ovary	26.7 nTPM
Esophagus	26.2 nTPM
Lung	24.3 nTPM
Stomach	20.7 nTPM

Basal keratinocytes	72.1 nTPM
Skin	72.1 nTPM

Basal prostatic cells	33.9 nTPM
Prostate	33.9 nTPM

Basal squamous epithelial cells	46.7 nTPM
Esophagus	46.7 nTPM

Cholangiocytes	40.0 nTPM
Liver	40.0 nTPM

Undifferentiated cells	33.1 nTPM
Rectum	43.0 nTPM
Small intestine	37.8 nTPM
Colon	18.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC