Single cell type - NHLRC2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NHLRC2
Gene descriptionⁱ Full gene name according to HGNC.	NHL repeat containing 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NHLRC2 is part of cluster 52 Non-specific - Transcription with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
APOOL	Apolipoprotein O like	0.5691	54
DBT	Dihydrolipoamide branched chain transacylase E2	0.4993	39
TTC37	Tetratricopeptide repeat domain 37	0.4909	52
ZBTB41	Zinc finger and BTB domain containing 41	0.4843	52
ACOT1	Acyl-CoA thioesterase 1	0.4795	54
RAB9B	RAB9B, member RAS oncogene family	0.4723	54
CDH2	Cadherin 2	0.4706	40
ZMYND11	Zinc finger MYND-type containing 11	0.4630	10
TAS2R5	Taste 2 receptor member 5	0.4618	68
PPP1R12B	Protein phosphatase 1 regulatory subunit 12B	0.4570	40
ADCY5	Adenylate cyclase 5	0.4415	54
HACD1	3-hydroxyacyl-CoA dehydratase 1	0.4352	54
TRAK2	Trafficking kinesin protein 2	0.4319	6
MTX3	Metaxin 3	0.4307	52
ZNF638	Zinc finger protein 638	0.4288	52

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.4 nTPM
Adipose tissue	28.6 nTPM
Breast	16.3 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	21.3 nTPM
Lung	21.3 nTPM

Astrocytes	40.5 nTPM
Brain	40.5 nTPM

B-cells	13.7 nTPM
Bone marrow	32.7 nTPM
Spleen	16.2 nTPM
Stomach	15.9 nTPM
Adipose tissue	14.6 nTPM
Kidney	14.3 nTPM
PBMC	14.3 nTPM
Liver	11.0 nTPM
Lymph node	10.2 nTPM
Colon	6.4 nTPM
Breast	1.3 nTPM

Dendritic cells	8.3 nTPM
Adipose tissue	12.7 nTPM
Breast	12.0 nTPM
PBMC	0.0 nTPM

Endothelial cells	19.4 nTPM
Heart muscle	37.8 nTPM
Liver	30.2 nTPM
Lung	24.9 nTPM
Esophagus	22.1 nTPM
Eye	21.8 nTPM
Endometrium	21.6 nTPM
Ovary	21.5 nTPM
Skeletal muscle	21.0 nTPM
Placenta	17.6 nTPM
Testis	15.1 nTPM
Breast	12.1 nTPM
Prostate	11.0 nTPM
Pancreas	7.7 nTPM
Skin	6.4 nTPM

Fibroblasts	19.3 nTPM
Heart muscle	36.6 nTPM
Adipose tissue	29.5 nTPM
Esophagus	26.3 nTPM
Skeletal muscle	25.5 nTPM
Stomach	25.3 nTPM
Ovary	17.0 nTPM
Breast	15.4 nTPM
Placenta	11.8 nTPM
Prostate	11.8 nTPM
Lung	6.7 nTPM
Skin	6.3 nTPM

Intestinal goblet cells	15.8 nTPM
Rectum	20.7 nTPM
Small intestine	17.5 nTPM
Colon	9.3 nTPM

Macrophages	13.7 nTPM
Testis	31.4 nTPM
Bone marrow	28.7 nTPM
Adipose tissue	20.1 nTPM
Esophagus	17.3 nTPM
Ovary	15.8 nTPM
Kidney	12.9 nTPM
Skeletal muscle	12.9 nTPM
Pancreas	12.8 nTPM
Endometrium	12.7 nTPM
Lung	9.7 nTPM
Spleen	9.3 nTPM
Breast	8.7 nTPM
Prostate	6.9 nTPM
Stomach	5.9 nTPM
PBMC	0.0 nTPM

Paneth cells	15.4 nTPM
Small intestine	22.5 nTPM
Rectum	13.7 nTPM
Colon	9.9 nTPM

Plasma cells	9.1 nTPM
Adipose tissue	12.2 nTPM
Bone marrow	9.9 nTPM
Spleen	9.8 nTPM
Stomach	7.4 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	8.9 nTPM
Bronchus	12.0 nTPM
Lung	5.8 nTPM

Smooth muscle cells	19.1 nTPM
Adipose tissue	40.7 nTPM
Heart muscle	39.1 nTPM
Skeletal muscle	26.4 nTPM
Endometrium	20.3 nTPM
Breast	18.9 nTPM
Esophagus	18.6 nTPM
Ovary	17.0 nTPM
Prostate	11.2 nTPM
Bronchus	7.5 nTPM
Pancreas	6.6 nTPM
Skin	4.2 nTPM

T-cells	10.9 nTPM
Lung	18.2 nTPM
Bone marrow	17.6 nTPM
Skeletal muscle	13.7 nTPM
Ovary	13.4 nTPM
Endometrium	12.4 nTPM
Liver	11.9 nTPM
Kidney	11.6 nTPM
Adipose tissue	11.4 nTPM
Stomach	11.4 nTPM
PBMC	10.9 nTPM
Prostate	9.5 nTPM
Spleen	8.3 nTPM
Breast	8.3 nTPM
Skin	7.8 nTPM
Esophagus	6.6 nTPM
Colon	6.2 nTPM
Lymph node	5.5 nTPM

Basal keratinocytes	7.9 nTPM
Skin	7.9 nTPM

Basal prostatic cells	13.1 nTPM
Prostate	13.1 nTPM

Collecting duct cells	36.8 nTPM
Kidney	36.8 nTPM

Cytotrophoblasts	16.8 nTPM
Placenta	16.8 nTPM

Undifferentiated cells	12.3 nTPM
Small intestine	14.1 nTPM
Rectum	13.5 nTPM
Colon	9.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC