Single cell type - FLNA - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FLNA
Gene descriptionⁱ Full gene name according to HGNC.	Filamin A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Smooth muscle cells - ECM organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Peritubular cells, Smooth muscle cells, Sertoli cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Peritubular cells, Smooth muscle cells, Sertoli cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FLNA is part of cluster 48 Smooth muscle cells - ECM organization with confidenceⁱ 1
270 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TGFB1I1	Transforming growth factor beta 1 induced transcript 1	0.7614	48
ITGB1	Integrin subunit beta 1	0.7134	48
TAGLN	Transgelin	0.6576	48
IGFBP7	Insulin like growth factor binding protein 7	0.6317	48
MYL9	Myosin light chain 9	0.6250	48
INHBA	Inhibin subunit beta A	0.6161	48
ACTA2	Actin alpha 2, smooth muscle	0.6141	48
NDN	Necdin, MAGE family member	0.6056	48
RASL12	RAS like family 12	0.6053	48
BGN	Biglycan	0.6001	48
FOXS1	Forkhead box S1	0.5988	48
PDLIM7	PDZ and LIM domain 7	0.5971	1
PPP1R14A	Protein phosphatase 1 regulatory inhibitor subunit 14A	0.5913	48
COL4A2	Collagen type IV alpha 2 chain	0.5848	48
WTIP	WT1 interacting protein	0.5774	48

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	105.1 nTPM
Breast	112.6 nTPM
Adipose tissue	97.7 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	38.7 nTPM
Lung	38.7 nTPM

Astrocytes	30.0 nTPM
Brain	30.0 nTPM

B-cells	76.9 nTPM
Breast	121.6 nTPM
Adipose tissue	100.7 nTPM
Lymph node	88.4 nTPM
Colon	86.3 nTPM
Stomach	77.2 nTPM
Bone marrow	74.4 nTPM
Spleen	68.2 nTPM
PBMC	61.4 nTPM
Liver	57.2 nTPM
Kidney	33.4 nTPM

Dendritic cells	257.7 nTPM
Breast	457.8 nTPM
Adipose tissue	271.4 nTPM
PBMC	43.8 nTPM

Endothelial cells	107.0 nTPM
Ovary	366.6 nTPM
Pancreas	131.3 nTPM
Testis	118.8 nTPM
Endometrium	113.1 nTPM
Placenta	112.6 nTPM
Skeletal muscle	102.2 nTPM
Breast	102.2 nTPM
Skin	94.9 nTPM
Eye	83.3 nTPM
Esophagus	73.9 nTPM
Liver	66.0 nTPM
Prostate	56.4 nTPM
Heart muscle	54.3 nTPM
Lung	21.8 nTPM

Fibroblasts	137.9 nTPM
Ovary	389.6 nTPM
Placenta	252.5 nTPM
Stomach	145.5 nTPM
Skin	138.0 nTPM
Breast	126.2 nTPM
Adipose tissue	125.8 nTPM
Skeletal muscle	117.8 nTPM
Prostate	82.5 nTPM
Esophagus	66.4 nTPM
Lung	41.3 nTPM
Heart muscle	31.4 nTPM

Intestinal goblet cells	2.5 nTPM
Colon	5.0 nTPM
Rectum	1.7 nTPM
Small intestine	0.8 nTPM

Macrophages	227.7 nTPM
PBMC	668.4 nTPM
Stomach	424.9 nTPM
Adipose tissue	314.4 nTPM
Bone marrow	268.6 nTPM
Skeletal muscle	263.4 nTPM
Spleen	261.3 nTPM
Kidney	206.4 nTPM
Pancreas	165.9 nTPM
Breast	146.2 nTPM
Esophagus	127.4 nTPM
Endometrium	126.8 nTPM
Lung	124.5 nTPM
Prostate	121.5 nTPM
Testis	106.8 nTPM
Ovary	88.4 nTPM

Paneth cells	1.5 nTPM
Small intestine	3.7 nTPM
Rectum	0.9 nTPM
Colon	0.0 nTPM

Plasma cells	98.7 nTPM
Adipose tissue	294.1 nTPM
Bone marrow	65.9 nTPM
Esophagus	55.5 nTPM
Spleen	53.9 nTPM
Stomach	23.9 nTPM

Respiratory ciliated cells	9.1 nTPM
Bronchus	13.8 nTPM
Lung	4.4 nTPM

Smooth muscle cells	459.3 nTPM
Breast	811.3 nTPM
Esophagus	624.9 nTPM
Skin	598.4 nTPM
Skeletal muscle	563.3 nTPM
Prostate	549.3 nTPM
Pancreas	410.3 nTPM
Ovary	404.6 nTPM
Adipose tissue	401.7 nTPM
Heart muscle	343.7 nTPM
Endometrium	322.5 nTPM
Bronchus	21.8 nTPM

T-cells	172.3 nTPM
Skeletal muscle	336.3 nTPM
Skin	259.3 nTPM
Breast	253.6 nTPM
Bone marrow	251.9 nTPM
Adipose tissue	217.9 nTPM
Spleen	200.4 nTPM
Ovary	195.7 nTPM
Endometrium	170.4 nTPM
Esophagus	170.3 nTPM
Stomach	164.1 nTPM
PBMC	157.6 nTPM
Kidney	146.5 nTPM
Lymph node	128.1 nTPM
Colon	113.6 nTPM
Liver	91.2 nTPM
Lung	44.0 nTPM
Prostate	28.4 nTPM

Basal keratinocytes	124.3 nTPM
Skin	124.3 nTPM

Basal prostatic cells	85.9 nTPM
Prostate	85.9 nTPM

Basal respiratory cells	127.8 nTPM
Bronchus	127.8 nTPM

Basal squamous epithelial cells	85.4 nTPM
Esophagus	85.4 nTPM

Undifferentiated cells	3.3 nTPM
Colon	3.8 nTPM
Small intestine	3.1 nTPM
Rectum	3.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC