Single cell type - FAM3C - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM3C
Gene descriptionⁱ Full gene name according to HGNC.	FAM3 metabolism regulating signaling molecule C
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic endocrine cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Pancreatic endocrine cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (memory B-cell, naive B-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CAPAN-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Pancreatic endocrine cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FAM3C is part of cluster 16 Pancreatic endocrine cells - Mixed function with confidenceⁱ 0.96
171 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PLAU	Plasminogen activator, urokinase	0.7068	22
ANXA2	Annexin A2	0.6928	16
DKK4	Dickkopf WNT signaling pathway inhibitor 4	0.6834	16
S100A6	S100 calcium binding protein A6	0.6635	16
F3	Coagulation factor III, tissue factor	0.6485	16
KPNA7	Karyopherin subunit alpha 7	0.6469	16
HCCS	Holocytochrome c synthase	0.6394	22
HMGA1	High mobility group AT-hook 1	0.6331	16
GJB4	Gap junction protein beta 4	0.6330	22
CD59	CD59 molecule (CD59 blood group)	0.6288	22
ADGRF1	Adhesion G protein-coupled receptor F1	0.6180	22
ERO1A	Endoplasmic reticulum oxidoreductase 1 alpha	0.6128	16
LAMC2	Laminin subunit gamma 2	0.6052	16
TGFA	Transforming growth factor alpha	0.5888	22
PDLIM4	PDZ and LIM domain 4	0.5886	22

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	49.8 nTPM
Breast	50.2 nTPM
Adipose tissue	49.5 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	33.3 nTPM
Lung	33.3 nTPM

Astrocytes	17.3 nTPM
Brain	17.3 nTPM

B-cells	103.0 nTPM
Liver	127.8 nTPM
Adipose tissue	124.3 nTPM
Bone marrow	122.6 nTPM
Spleen	108.3 nTPM
Breast	106.9 nTPM
Lymph node	100.6 nTPM
Stomach	93.1 nTPM
PBMC	89.9 nTPM
Colon	84.7 nTPM
Kidney	71.4 nTPM

Dendritic cells	44.8 nTPM
Adipose tissue	60.6 nTPM
Breast	45.9 nTPM
PBMC	27.9 nTPM

Endothelial cells	58.9 nTPM
Prostate	138.0 nTPM
Skin	95.0 nTPM
Pancreas	73.4 nTPM
Breast	54.9 nTPM
Skeletal muscle	54.5 nTPM
Lung	53.0 nTPM
Endometrium	52.9 nTPM
Esophagus	51.0 nTPM
Liver	46.7 nTPM
Ovary	46.3 nTPM
Eye	42.1 nTPM
Placenta	39.8 nTPM
Testis	39.4 nTPM
Heart muscle	37.2 nTPM

Fibroblasts	104.3 nTPM
Skin	190.0 nTPM
Prostate	168.6 nTPM
Adipose tissue	134.0 nTPM
Skeletal muscle	128.0 nTPM
Breast	107.2 nTPM
Stomach	86.1 nTPM
Esophagus	85.9 nTPM
Placenta	85.5 nTPM
Ovary	58.8 nTPM
Heart muscle	53.9 nTPM
Lung	49.2 nTPM

Intestinal goblet cells	49.1 nTPM
Small intestine	67.4 nTPM
Rectum	48.4 nTPM
Colon	31.5 nTPM

Macrophages	30.9 nTPM
Prostate	66.4 nTPM
Pancreas	56.2 nTPM
Adipose tissue	40.2 nTPM
Kidney	38.6 nTPM
Ovary	37.2 nTPM
Endometrium	34.8 nTPM
Testis	30.8 nTPM
Breast	29.4 nTPM
Skeletal muscle	28.6 nTPM
Lung	24.8 nTPM
Esophagus	23.6 nTPM
Stomach	20.5 nTPM
Bone marrow	16.3 nTPM
Spleen	15.6 nTPM
PBMC	0.0 nTPM

Paneth cells	71.9 nTPM
Rectum	103.3 nTPM
Small intestine	82.6 nTPM
Colon	29.6 nTPM

Plasma cells	129.8 nTPM
Stomach	198.1 nTPM
Spleen	159.3 nTPM
Adipose tissue	110.2 nTPM
Esophagus	92.4 nTPM
Bone marrow	88.9 nTPM

Respiratory ciliated cells	63.9 nTPM
Bronchus	85.5 nTPM
Lung	42.3 nTPM

Smooth muscle cells	68.7 nTPM
Pancreas	99.1 nTPM
Skin	95.6 nTPM
Prostate	84.7 nTPM
Skeletal muscle	82.8 nTPM
Ovary	75.9 nTPM
Bronchus	69.2 nTPM
Adipose tissue	66.8 nTPM
Endometrium	54.7 nTPM
Breast	53.3 nTPM
Heart muscle	39.1 nTPM
Esophagus	34.1 nTPM

T-cells	44.3 nTPM
Prostate	118.3 nTPM
Colon	86.9 nTPM
Stomach	65.0 nTPM
Skin	64.4 nTPM
Ovary	53.4 nTPM
Liver	44.1 nTPM
Adipose tissue	44.1 nTPM
Endometrium	41.5 nTPM
Skeletal muscle	41.1 nTPM
Kidney	35.6 nTPM
Breast	34.6 nTPM
Spleen	29.7 nTPM
Lymph node	27.6 nTPM
Bone marrow	25.1 nTPM
PBMC	20.7 nTPM
Lung	15.2 nTPM
Esophagus	6.6 nTPM

Basal keratinocytes	71.8 nTPM
Skin	71.8 nTPM

Basal prostatic cells	257.1 nTPM
Prostate	257.1 nTPM

Basal respiratory cells	183.0 nTPM
Bronchus	183.0 nTPM

Basal squamous epithelial cells	61.5 nTPM
Esophagus	61.5 nTPM

Undifferentiated cells	86.7 nTPM
Rectum	103.2 nTPM
Colon	81.6 nTPM
Small intestine	75.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC