Single cell type - PSAP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PSAP
Gene descriptionⁱ Full gene name according to HGNC.	Prosaposin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Macrophages - Innate immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells, Kupffer cells, Macrophages)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (intermediate monocyte)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, hTERT-RPE1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells, Kupffer cells, Macrophages)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PSAP is part of cluster 4 Macrophages - Innate immune response with confidenceⁱ 1
228 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CTSB	Cathepsin B	0.7883	4
ADAMDEC1	ADAM like decysin 1	0.7619	4
IGSF6	Immunoglobulin superfamily member 6	0.7492	4
SLC37A2	Solute carrier family 37 member 2	0.7408	4
CTSD	Cathepsin D	0.7386	4
DNASE2	Deoxyribonuclease 2, lysosomal	0.7373	4
GRN	Granulin precursor	0.7371	4
DCSTAMP	Dendrocyte expressed seven transmembrane protein	0.7320	4
SIGLEC9	Sialic acid binding Ig like lectin 9	0.7294	4
LIPA	Lipase A, lysosomal acid type	0.7262	4
CCL7	C-C motif chemokine ligand 7	0.7260	4
CREG1	Cellular repressor of E1A stimulated genes 1	0.7259	4
PLA2G7	Phospholipase A2 group VII	0.7242	4
ACP5	Acid phosphatase 5, tartrate resistant	0.7199	4
CD300C	CD300c molecule	0.7179	19

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	263.2 nTPM
Adipose tissue	363.9 nTPM
Breast	162.5 nTPM

Alveolar cells type 1	253.2 nTPM
Lung	253.2 nTPM

Alveolar cells type 2	339.0 nTPM
Lung	339.0 nTPM

Astrocytes	136.8 nTPM
Brain	136.8 nTPM

B-cells	173.9 nTPM
Liver	316.0 nTPM
Breast	193.8 nTPM
Colon	191.7 nTPM
Stomach	178.4 nTPM
Bone marrow	173.3 nTPM
Lymph node	165.0 nTPM
Spleen	161.3 nTPM
PBMC	149.9 nTPM
Kidney	104.8 nTPM
Adipose tissue	104.3 nTPM

Basal squamous epithelial cells	108.1 nTPM
Esophagus	108.1 nTPM

Dendritic cells	260.2 nTPM
PBMC	506.1 nTPM
Adipose tissue	182.0 nTPM
Breast	92.6 nTPM

Endothelial cells	311.4 nTPM
Liver	422.9 nTPM
Placenta	410.4 nTPM
Eye	394.9 nTPM
Pancreas	389.9 nTPM
Heart muscle	368.4 nTPM
Lung	368.0 nTPM
Skeletal muscle	307.3 nTPM
Skin	298.1 nTPM
Breast	268.4 nTPM
Testis	257.5 nTPM
Prostate	233.5 nTPM
Esophagus	224.7 nTPM
Ovary	219.4 nTPM
Endometrium	196.9 nTPM

Enteroendocrine cells	261.9 nTPM
Rectum	310.6 nTPM
Colon	213.2 nTPM

Erythroid cells	160.5 nTPM
Liver	203.4 nTPM
Bone marrow	117.7 nTPM

Fibroblasts	623.8 nTPM
Esophagus	1030.9 nTPM
Adipose tissue	1016.7 nTPM
Skin	871.2 nTPM
Stomach	828.5 nTPM
Heart muscle	681.5 nTPM
Prostate	633.4 nTPM
Skeletal muscle	523.6 nTPM
Breast	459.6 nTPM
Lung	349.6 nTPM
Placenta	328.0 nTPM
Ovary	138.8 nTPM

Intestinal goblet cells	242.2 nTPM
Rectum	286.4 nTPM
Colon	275.9 nTPM
Small intestine	164.4 nTPM

Macrophages	1916.9 nTPM
Pancreas	3989.3 nTPM
Ovary	3371.9 nTPM
Bone marrow	3046.3 nTPM
Kidney	2934.2 nTPM
Stomach	2473.1 nTPM
Spleen	2442.8 nTPM
Lung	2183.0 nTPM
Prostate	1620.9 nTPM
Adipose tissue	1425.4 nTPM
Esophagus	1420.9 nTPM
Skeletal muscle	1115.8 nTPM
Testis	1025.3 nTPM
Endometrium	950.9 nTPM
Breast	549.0 nTPM
PBMC	204.6 nTPM

Paneth cells	298.3 nTPM
Colon	326.0 nTPM
Rectum	317.2 nTPM
Small intestine	251.5 nTPM

Plasma cells	503.0 nTPM
Stomach	895.3 nTPM
Esophagus	677.5 nTPM
Bone marrow	326.3 nTPM
Spleen	322.5 nTPM
Adipose tissue	293.5 nTPM

Cholangiocytes	253.1 nTPM
Liver	253.1 nTPM

Collecting duct cells	476.3 nTPM
Kidney	476.3 nTPM

Cone photoreceptor cells	127.2 nTPM
Eye	127.2 nTPM

Cytotrophoblasts	891.6 nTPM
Placenta	891.6 nTPM

Respiratory ciliated cells	297.2 nTPM
Bronchus	355.3 nTPM
Lung	239.0 nTPM

Smooth muscle cells	263.8 nTPM
Pancreas	464.4 nTPM
Heart muscle	372.4 nTPM
Adipose tissue	357.3 nTPM
Prostate	309.4 nTPM
Esophagus	288.4 nTPM
Skeletal muscle	267.7 nTPM
Skin	265.0 nTPM
Ovary	156.7 nTPM
Bronchus	150.1 nTPM
Breast	138.2 nTPM
Endometrium	132.0 nTPM

T-cells	138.9 nTPM
Lung	369.1 nTPM
Skin	201.3 nTPM
Kidney	188.9 nTPM
Liver	155.7 nTPM
Prostate	151.5 nTPM
Stomach	141.7 nTPM
Bone marrow	137.0 nTPM
Adipose tissue	133.0 nTPM
Skeletal muscle	127.1 nTPM
Spleen	126.7 nTPM
PBMC	120.0 nTPM
Lymph node	111.7 nTPM
Colon	98.8 nTPM
Endometrium	92.8 nTPM
Ovary	80.1 nTPM
Breast	66.3 nTPM
Esophagus	58.9 nTPM

Undifferentiated cells	228.3 nTPM
Colon	282.3 nTPM
Rectum	253.9 nTPM
Small intestine	148.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC