Brain tissue expression of AKAP17A - Summary - The Human Protein Atlas

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AKAP17A

SUMMARY

TISSUE

BRAIN

SINGLE CELL

TISSUE CELL

PATHOLOGY

IMMUNE

BLOOD

SUBCELL

CELL LINE

METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Human gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AKAP17A
Human gene descriptionⁱ Full gene name according to HGNC.	A-kinase anchoring protein 17A
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Mouse gene	No orthologous mouse gene.
Pig gene	ENSSSCG00000032986 (version 103)
Antibodies in assayⁱ The internal antibody ID for the antibody/antibodies available for this specific target, click link for more antibody information.	HPA043247

HUMAN PROTEIN ATLAS INFORMATION
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Low tissue specificity
	Human brain	Pig brain
Regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity	Low region specificity
Regional distributionⁱ The regional distribution category is based on mRNA expression detected above cut off or not in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. Brain expression for all species is based on data from HPA. The distribution categories include: detected in all, detected in many, detected in some, detected in single and not detected. The classification rules are the same used for the tissue distribution category. Read more	Detected in all	Detected in all
Protein profileⁱ A summary of the overall protein localization across the analyzed brain tissue. The summary is based on manual annotation. Mouse brain profiles includes a more extensive summary of the protein location while summaries with only human protein profile are more limited and are based on imported data/images from the Tissue Atlas stainings that has undergone an additional brain-centric curation step. Read more	Nuclear protein detected in a subset of glial cells in all forebrain regions, possibly astrocytes. Distinct positivity also observed in cerebellar granular layer.

BRAIN RNA EXPRESSION

HUMAN

Cerebral cortex Hippocampal formation Amygdala Basal ganglia Thalamus Hypothalamus Midbrain Cerebellum Pons Medulla oblongata Spinal cord White matter Corpus callosum Expression Detection All organs	HPA Human brain datasetⁱ Normalized RNA expression levels (nTPM) shown for the 13 brain regions. Color coding is based on brain region and the bar shows the highest expression among the subregions included. To access sample data, click on region name or bar. Read more about normalized expression levels in Assays & Annotation.
CTX HPF AMY BG TH HY MB CB P M SC WM
Cerebral cortex Hippocampal formation Amygdala Basal ganglia Thalamus Hypothalamus Midbrain Cerebellum Pons Medulla oblongata Spinal cord White matter

COMPARISON BRAIN RNA EXPRESSION

GTEX AND FANTOM HUMAN BRAIN

GTEx Human brain RNA-Seq datasetⁱ

FANTOM5 Human brain CAGE datasetⁱ

PIG

HPA Pig brain RNA-Seq datasetⁱ

HUMAN BRAIN PROTEIN LOCATIONⁱ

Location example	Cerebellum
Location summary	Nuclear protein detected in a subset of glial cells in all forebrain regions, possibly astrocytes. Distinct positivity also observed in cerebellar granular layer.
Antibody reliability	Supported based on HPA043247

HPA Human protein locationⁱ

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.