Single cell type - DZIP3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DZIP3
Gene descriptionⁱ Full gene name according to HGNC.	DAZ interacting zinc finger protein 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Ciliated cells - Cilium organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes, Cone photoreceptor cells, Respiratory ciliated cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes, Cone photoreceptor cells, Respiratory ciliated cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DZIP3 is part of cluster 49 Ciliated cells - Cilium organization with confidenceⁱ 1
457 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IFT81	Intraflagellar transport 81	0.6771	49
AK9	Adenylate kinase 9	0.6673	49
ANKRD54	Ankyrin repeat domain 54	0.6538	49
TDRD9	Tudor domain containing 9	0.6421	13
IFT140	Intraflagellar transport 140	0.6229	49
IFT88	Intraflagellar transport 88	0.6092	49
ZNF446	Zinc finger protein 446	0.6088	13
IFT122	Intraflagellar transport 122	0.5974	66
TMEM67	Transmembrane protein 67	0.5939	49
STK36	Serine/threonine kinase 36	0.5792	49
TMEM17	Transmembrane protein 17	0.5659	13
ANKRD62	Ankyrin repeat domain 62	0.5647	66
HYDIN	HYDIN axonemal central pair apparatus protein	0.5589	49
CCP110	Centriolar coiled-coil protein 110	0.5575	49
MAP6	Microtubule associated protein 6	0.5551	56

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	7.3 nTPM
Adipose tissue	7.8 nTPM
Breast	6.8 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	12.8 nTPM
Lung	12.8 nTPM

Astrocytes	86.8 nTPM
Brain	86.8 nTPM

B-cells	14.8 nTPM
PBMC	22.8 nTPM
Spleen	20.1 nTPM
Stomach	18.2 nTPM
Lymph node	18.0 nTPM
Adipose tissue	16.1 nTPM
Colon	14.4 nTPM
Bone marrow	13.1 nTPM
Kidney	9.5 nTPM
Liver	9.2 nTPM
Breast	6.6 nTPM

Dendritic cells	17.1 nTPM
PBMC	20.0 nTPM
Adipose tissue	16.2 nTPM
Breast	14.9 nTPM

Endothelial cells	8.7 nTPM
Eye	16.2 nTPM
Lung	15.6 nTPM
Skeletal muscle	9.5 nTPM
Placenta	9.1 nTPM
Testis	8.9 nTPM
Skin	8.8 nTPM
Heart muscle	8.5 nTPM
Pancreas	7.7 nTPM
Breast	7.5 nTPM
Liver	7.3 nTPM
Endometrium	6.6 nTPM
Ovary	6.5 nTPM
Esophagus	5.8 nTPM
Prostate	4.0 nTPM

Fibroblasts	18.2 nTPM
Heart muscle	37.4 nTPM
Breast	21.0 nTPM
Skeletal muscle	19.8 nTPM
Esophagus	19.8 nTPM
Adipose tissue	18.9 nTPM
Lung	17.9 nTPM
Ovary	16.9 nTPM
Placenta	15.2 nTPM
Skin	14.3 nTPM
Stomach	11.9 nTPM
Prostate	7.4 nTPM

Intestinal goblet cells	6.9 nTPM
Rectum	7.7 nTPM
Small intestine	6.6 nTPM
Colon	6.5 nTPM

Macrophages	5.7 nTPM
Spleen	12.5 nTPM
Lung	11.4 nTPM
Breast	9.4 nTPM
Endometrium	7.9 nTPM
Skeletal muscle	7.5 nTPM
Prostate	6.9 nTPM
Testis	5.8 nTPM
Ovary	5.6 nTPM
Adipose tissue	5.2 nTPM
Pancreas	5.1 nTPM
Kidney	4.6 nTPM
Bone marrow	2.5 nTPM
Esophagus	1.6 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	4.6 nTPM
Rectum	7.0 nTPM
Small intestine	3.7 nTPM
Colon	3.3 nTPM

Plasma cells	9.0 nTPM
Adipose tissue	14.2 nTPM
Bone marrow	11.5 nTPM
Spleen	10.4 nTPM
Stomach	8.9 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	218.2 nTPM
Bronchus	236.6 nTPM
Lung	199.7 nTPM

Smooth muscle cells	17.7 nTPM
Bronchus	41.3 nTPM
Heart muscle	27.2 nTPM
Esophagus	18.6 nTPM
Adipose tissue	17.2 nTPM
Skeletal muscle	16.9 nTPM
Skin	16.7 nTPM
Ovary	13.4 nTPM
Breast	13.3 nTPM
Endometrium	13.1 nTPM
Prostate	10.3 nTPM
Pancreas	6.7 nTPM

T-cells	29.4 nTPM
Colon	68.4 nTPM
Stomach	50.3 nTPM
Skin	45.1 nTPM
Liver	35.8 nTPM
Endometrium	34.7 nTPM
Breast	32.5 nTPM
Skeletal muscle	29.1 nTPM
PBMC	27.0 nTPM
Adipose tissue	26.2 nTPM
Spleen	25.2 nTPM
Bone marrow	24.9 nTPM
Lymph node	21.5 nTPM
Kidney	19.8 nTPM
Esophagus	19.7 nTPM
Lung	16.7 nTPM
Ovary	13.4 nTPM
Prostate	9.5 nTPM

Basal prostatic cells	8.6 nTPM
Prostate	8.6 nTPM

Basal respiratory cells	16.3 nTPM
Bronchus	16.3 nTPM

Cholangiocytes	4.3 nTPM
Liver	4.3 nTPM

Collecting duct cells	33.1 nTPM
Kidney	33.1 nTPM

Undifferentiated cells	7.4 nTPM
Colon	8.6 nTPM
Small intestine	7.2 nTPM
Rectum	6.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC