Single cell type - INF2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	INF2
Gene descriptionⁱ Full gene name according to HGNC.	Inverted formin 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal enterocytes, Gastric mucus-secreting cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (PC-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal enterocytes, Gastric mucus-secreting cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

INF2 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PKP3	Plakophilin 3	0.7817	53
TRIM40	Tripartite motif containing 40	0.7757	53
ARL14	ADP ribosylation factor like GTPase 14	0.7757	53
ARHGEF16	Rho guanine nucleotide exchange factor 16	0.7744	53
TRIM15	Tripartite motif containing 15	0.7553	53
UGT2B17	UDP glucuronosyltransferase family 2 member B17	0.7291	53
MYH14	Myosin heavy chain 14	0.7007	53
PLEC	Plectin	0.6994	53
PDE4C	Phosphodiesterase 4C	0.6957	53
TPRN	Taperin	0.6907	53
CCNYL1	Cyclin Y like 1	0.6886	53
FBLIM1	Filamin binding LIM protein 1	0.6864	53
MST1R	Macrophage stimulating 1 receptor	0.6736	53
CGN	Cingulin	0.6732	53
BATF2	Basic leucine zipper ATF-like transcription factor 2	0.6725	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	48.8 nTPM
Adipose tissue	51.1 nTPM
Breast	46.6 nTPM

Alveolar cells type 1	64.1 nTPM
Lung	64.1 nTPM

Alveolar cells type 2	13.4 nTPM
Lung	13.4 nTPM

Astrocytes	10.1 nTPM
Brain	10.1 nTPM

B-cells	22.5 nTPM
Colon	31.9 nTPM
Stomach	30.0 nTPM
Bone marrow	27.0 nTPM
Spleen	26.3 nTPM
Lymph node	24.6 nTPM
Adipose tissue	23.1 nTPM
Breast	22.8 nTPM
Kidney	14.3 nTPM
Liver	13.1 nTPM
PBMC	11.5 nTPM

Dendritic cells	5.2 nTPM
PBMC	8.0 nTPM
Adipose tissue	4.0 nTPM
Breast	3.6 nTPM

Endothelial cells	29.8 nTPM
Ovary	68.3 nTPM
Heart muscle	48.0 nTPM
Skeletal muscle	37.6 nTPM
Breast	35.3 nTPM
Prostate	30.3 nTPM
Liver	28.4 nTPM
Testis	26.9 nTPM
Lung	24.9 nTPM
Placenta	24.5 nTPM
Endometrium	23.2 nTPM
Esophagus	23.1 nTPM
Skin	22.3 nTPM
Eye	12.9 nTPM
Pancreas	11.6 nTPM

Fibroblasts	17.9 nTPM
Lung	33.5 nTPM
Placenta	22.0 nTPM
Adipose tissue	20.3 nTPM
Ovary	18.1 nTPM
Skin	17.3 nTPM
Prostate	16.9 nTPM
Stomach	16.3 nTPM
Breast	15.8 nTPM
Skeletal muscle	14.6 nTPM
Esophagus	11.6 nTPM
Heart muscle	10.0 nTPM

Intestinal goblet cells	86.2 nTPM
Colon	145.8 nTPM
Rectum	58.3 nTPM
Small intestine	54.4 nTPM

Macrophages	25.5 nTPM
PBMC	163.7 nTPM
Ovary	30.0 nTPM
Adipose tissue	25.7 nTPM
Lung	23.2 nTPM
Pancreas	20.4 nTPM
Prostate	19.5 nTPM
Esophagus	18.9 nTPM
Breast	18.4 nTPM
Endometrium	15.3 nTPM
Skeletal muscle	14.5 nTPM
Stomach	8.8 nTPM
Kidney	6.8 nTPM
Testis	6.4 nTPM
Spleen	5.2 nTPM
Bone marrow	5.0 nTPM

Paneth cells	110.7 nTPM
Colon	253.7 nTPM
Rectum	55.8 nTPM
Small intestine	22.5 nTPM

Plasma cells	7.8 nTPM
Bone marrow	19.8 nTPM
Spleen	7.5 nTPM
Adipose tissue	6.4 nTPM
Stomach	5.4 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	9.4 nTPM
Bronchus	17.3 nTPM
Lung	1.5 nTPM

Smooth muscle cells	36.1 nTPM
Breast	59.7 nTPM
Heart muscle	59.1 nTPM
Esophagus	52.7 nTPM
Adipose tissue	39.6 nTPM
Skeletal muscle	35.1 nTPM
Prostate	31.6 nTPM
Endometrium	31.3 nTPM
Skin	30.6 nTPM
Pancreas	26.8 nTPM
Ovary	22.2 nTPM
Bronchus	8.4 nTPM

T-cells	9.3 nTPM
Skin	20.2 nTPM
Colon	15.7 nTPM
Lymph node	15.3 nTPM
Esophagus	13.1 nTPM
Skeletal muscle	10.2 nTPM
Spleen	10.2 nTPM
Bone marrow	9.7 nTPM
Prostate	9.5 nTPM
Kidney	8.2 nTPM
Endometrium	7.4 nTPM
PBMC	7.3 nTPM
Breast	6.5 nTPM
Stomach	6.4 nTPM
Lung	6.1 nTPM
Adipose tissue	5.6 nTPM
Ovary	4.5 nTPM
Liver	2.8 nTPM

Basal keratinocytes	22.7 nTPM
Skin	22.7 nTPM

Basal prostatic cells	17.5 nTPM
Prostate	17.5 nTPM

Basal respiratory cells	19.0 nTPM
Bronchus	19.0 nTPM

Cholangiocytes	28.6 nTPM
Liver	28.6 nTPM

Undifferentiated cells	66.9 nTPM
Colon	126.2 nTPM
Rectum	44.8 nTPM
Small intestine	29.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC