Single cell type - FCGR3A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FCGR3A
Gene descriptionⁱ Full gene name according to HGNC.	Fc fragment of IgG receptor IIIa
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	CD markers Disease related genes FDA approved drug targets Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells & T-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells, NK-cells, dendritic cells, Macrophages, Hofbauer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (non-classical monocyte, intermediate monocyte, neutrophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Not detected
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Not detected
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Kupffer cells, NK-cells, dendritic cells, Macrophages, Hofbauer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FCGR3A is part of cluster 63 NK-cells & T-cells - Immune response with confidenceⁱ 1
362 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CD300A	CD300a molecule	0.8807	63
ABI3	ABI family member 3	0.8635	63
SIGLEC7	Sialic acid binding Ig like lectin 7	0.8630	63
FGR	FGR proto-oncogene, Src family tyrosine kinase	0.8507	19
ITGB2	Integrin subunit beta 2	0.8503	63
MYO1F	Myosin IF	0.8373	63
AOAH	Acyloxyacyl hydrolase	0.8363	63
ITGAM	Integrin subunit alpha M	0.8255	19
CX3CR1	C-X3-C motif chemokine receptor 1	0.8210	63
STK10	Serine/threonine kinase 10	0.7783	63
PADI6	Peptidyl arginine deiminase 6	0.7366	63
GAB3	GRB2 associated binding protein 3	0.7365	63
ITGAL	Integrin subunit alpha L	0.7325	63
SH2D1B	SH2 domain containing 1B	0.7022	63
FCER1G	Fc fragment of IgE receptor Ig	0.6980	4

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	2.7 nTPM
Breast	4.4 nTPM
Adipose tissue	0.9 nTPM

Alveolar cells type 1	22.4 nTPM
Lung	22.4 nTPM

Alveolar cells type 2	24.6 nTPM
Lung	24.6 nTPM

Astrocytes	0.7 nTPM
Brain	0.7 nTPM

B-cells	6.5 nTPM
Colon	30.3 nTPM
Liver	17.7 nTPM
PBMC	11.5 nTPM
Bone marrow	2.5 nTPM
Adipose tissue	2.0 nTPM
Spleen	0.7 nTPM
Kidney	0.0 nTPM
Lymph node	0.0 nTPM
Stomach	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	333.4 nTPM
Adipose tissue	655.7 nTPM
Breast	344.4 nTPM
PBMC	0.0 nTPM

Endothelial cells	18.9 nTPM
Eye	223.3 nTPM
Lung	24.9 nTPM
Liver	10.1 nTPM
Placenta	3.4 nTPM
Heart muscle	1.5 nTPM
Skeletal muscle	1.1 nTPM
Breast	0.9 nTPM
Endometrium	0.1 nTPM
Prostate	0.0 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Ovary	0.0 nTPM
Esophagus	0.0 nTPM

Fibroblasts	3.9 nTPM
Lung	34.7 nTPM
Breast	4.6 nTPM
Placenta	1.5 nTPM
Stomach	1.5 nTPM
Esophagus	0.4 nTPM
Heart muscle	0.3 nTPM
Skeletal muscle	0.3 nTPM
Skin	0.2 nTPM
Adipose tissue	0.1 nTPM
Prostate	0.0 nTPM
Ovary	0.0 nTPM

Intestinal goblet cells	0.1 nTPM
Rectum	0.2 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Macrophages	300.0 nTPM
Bone marrow	758.4 nTPM
Testis	728.5 nTPM
Lung	585.2 nTPM
Kidney	544.5 nTPM
Spleen	360.8 nTPM
Breast	343.6 nTPM
Ovary	263.2 nTPM
Prostate	244.2 nTPM
Stomach	211.0 nTPM
Adipose tissue	154.8 nTPM
Skeletal muscle	121.9 nTPM
Endometrium	73.4 nTPM
Esophagus	69.3 nTPM
Pancreas	40.8 nTPM
PBMC	0.0 nTPM

Paneth cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Plasma cells	22.1 nTPM
Adipose tissue	99.9 nTPM
Bone marrow	6.6 nTPM
Spleen	3.2 nTPM
Stomach	0.9 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	5.8 nTPM
Lung	11.7 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	0.4 nTPM
Breast	2.4 nTPM
Heart muscle	0.8 nTPM
Skeletal muscle	0.5 nTPM
Prostate	0.4 nTPM
Ovary	0.1 nTPM
Pancreas	0.0 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM
Endometrium	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM

T-cells	88.0 nTPM
Ovary	349.3 nTPM
Kidney	234.1 nTPM
Liver	166.1 nTPM
Lung	157.9 nTPM
Bone marrow	145.1 nTPM
Skeletal muscle	132.8 nTPM
Spleen	97.0 nTPM
Adipose tissue	59.1 nTPM
Prostate	42.6 nTPM
PBMC	36.0 nTPM
Endometrium	20.1 nTPM
Esophagus	19.7 nTPM
Stomach	16.2 nTPM
Colon	9.0 nTPM
Breast	5.4 nTPM
Skin	5.0 nTPM
Lymph node	0.0 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Collecting duct cells	3.7 nTPM
Kidney	3.7 nTPM

Cone photoreceptor cells	2.1 nTPM
Eye	2.1 nTPM

Cytotrophoblasts	1.2 nTPM
Placenta	1.2 nTPM

Undifferentiated cells	0.0 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM
Rectum	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC