Single cell type - NRAS - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NRAS
Gene descriptionⁱ Full gene name according to HGNC.	NRAS proto-oncogene, GTPase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic endocrine cells - Mixed function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

NRAS is part of cluster 16 Pancreatic endocrine cells - Mixed function with confidenceⁱ 1
171 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
UBA1	Ubiquitin like modifier activating enzyme 1	0.5414	53
PATL1	PAT1 homolog 1, processing body mRNA decay factor	0.5310	44
PLEKHB2	Pleckstrin homology domain containing B2	0.5093	44
PPP2CB	Protein phosphatase 2 catalytic subunit beta	0.5079	53
PTBP3	Polypyrimidine tract binding protein 3	0.4875	44
FAM199X	Family with sequence similarity 199, X-linked	0.4749	67
SLC25A24	Solute carrier family 25 member 24	0.4726	53
MOB1A	MOB kinase activator 1A	0.4705	3
TPMT	Thiopurine S-methyltransferase	0.4693	67
PAFAH1B2	Platelet activating factor acetylhydrolase 1b catalytic subunit 2	0.4584	65
ERO1A	Endoplasmic reticulum oxidoreductase 1 alpha	0.4528	16
UFM1	Ubiquitin fold modifier 1	0.4516	55
PAK2	P21 (RAC1) activated kinase 2	0.4479	19
NUS1	NUS1 dehydrodolichyl diphosphate synthase subunit	0.4476	55
RAB5C	RAB5C, member RAS oncogene family	0.4461	16

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.7 nTPM
Adipose tissue	26.5 nTPM
Breast	18.9 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	16.5 nTPM
Lung	16.5 nTPM

Astrocytes	8.1 nTPM
Brain	8.1 nTPM

B-cells	25.9 nTPM
Colon	43.2 nTPM
Adipose tissue	38.1 nTPM
Stomach	31.4 nTPM
Liver	31.0 nTPM
Spleen	24.3 nTPM
Bone marrow	22.9 nTPM
Breast	21.3 nTPM
Lymph node	21.0 nTPM
Kidney	14.3 nTPM
PBMC	11.5 nTPM

Dendritic cells	27.7 nTPM
Adipose tissue	40.3 nTPM
Breast	22.9 nTPM
PBMC	20.0 nTPM

Endothelial cells	29.2 nTPM
Ovary	50.7 nTPM
Pancreas	50.2 nTPM
Prostate	41.2 nTPM
Endometrium	35.2 nTPM
Placenta	34.1 nTPM
Esophagus	30.9 nTPM
Skin	26.9 nTPM
Lung	24.9 nTPM
Liver	22.0 nTPM
Heart muscle	21.3 nTPM
Breast	21.1 nTPM
Skeletal muscle	20.7 nTPM
Testis	17.2 nTPM
Eye	12.9 nTPM

Fibroblasts	16.1 nTPM
Stomach	22.3 nTPM
Skin	22.2 nTPM
Ovary	19.8 nTPM
Adipose tissue	19.1 nTPM
Placenta	19.0 nTPM
Skeletal muscle	18.7 nTPM
Prostate	14.8 nTPM
Breast	14.2 nTPM
Esophagus	12.8 nTPM
Lung	8.9 nTPM
Heart muscle	5.3 nTPM

Intestinal goblet cells	28.1 nTPM
Rectum	36.7 nTPM
Small intestine	25.4 nTPM
Colon	22.1 nTPM

Macrophages	30.4 nTPM
Adipose tissue	49.8 nTPM
Stomach	41.0 nTPM
Prostate	40.1 nTPM
Bone marrow	36.3 nTPM
Spleen	34.2 nTPM
Endometrium	32.4 nTPM
Kidney	31.8 nTPM
Pancreas	30.7 nTPM
Ovary	29.6 nTPM
Esophagus	28.3 nTPM
Skeletal muscle	27.2 nTPM
Lung	25.2 nTPM
Testis	20.3 nTPM
Breast	15.2 nTPM
PBMC	13.6 nTPM

Paneth cells	32.9 nTPM
Colon	36.2 nTPM
Rectum	32.4 nTPM
Small intestine	30.0 nTPM

Plasma cells	39.6 nTPM
Spleen	57.9 nTPM
Stomach	52.5 nTPM
Esophagus	36.9 nTPM
Bone marrow	29.7 nTPM
Adipose tissue	21.3 nTPM

Respiratory ciliated cells	23.1 nTPM
Bronchus	25.8 nTPM
Lung	20.4 nTPM

Smooth muscle cells	15.3 nTPM
Pancreas	38.8 nTPM
Ovary	23.8 nTPM
Endometrium	22.5 nTPM
Prostate	15.0 nTPM
Adipose tissue	12.4 nTPM
Skin	11.5 nTPM
Breast	10.1 nTPM
Skeletal muscle	9.9 nTPM
Bronchus	8.6 nTPM
Heart muscle	8.0 nTPM
Esophagus	7.8 nTPM

T-cells	21.9 nTPM
Adipose tissue	37.2 nTPM
Stomach	34.2 nTPM
Colon	33.2 nTPM
Endometrium	29.3 nTPM
Spleen	28.4 nTPM
Skin	25.4 nTPM
Lung	24.3 nTPM
Liver	22.5 nTPM
Kidney	21.2 nTPM
Bone marrow	20.1 nTPM
Lymph node	19.3 nTPM
Breast	17.6 nTPM
Skeletal muscle	16.9 nTPM
PBMC	15.1 nTPM
Prostate	14.2 nTPM
Ovary	13.4 nTPM
Esophagus	0.0 nTPM

Basal prostatic cells	31.2 nTPM
Prostate	31.2 nTPM

Basal squamous epithelial cells	15.4 nTPM
Esophagus	15.4 nTPM

Cholangiocytes	18.6 nTPM
Liver	18.6 nTPM

Cone photoreceptor cells	8.4 nTPM
Eye	8.4 nTPM

Undifferentiated cells	28.8 nTPM
Rectum	31.0 nTPM
Colon	28.9 nTPM
Small intestine	26.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC