Single cell type - BBIP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BBIP1
Gene descriptionⁱ Full gene name according to HGNC.	BBSome interacting protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Early spermatids, Late spermatids, Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Early spermatids, Late spermatids, Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

BBIP1 is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 1
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C22orf23	Chromosome 22 open reading frame 23	0.7321	66
EFCAB5	EF-hand calcium binding domain 5	0.6821	66
CETN1	Centrin 1	0.6637	66
PPP3R2	Protein phosphatase 3 regulatory subunit B, beta	0.6553	66
PDE6D	Phosphodiesterase 6D	0.6502	66
PRKACG	Protein kinase cAMP-activated catalytic subunit gamma	0.6456	66
ZNF846	Zinc finger protein 846	0.6449	66
ZNF596	Zinc finger protein 596	0.6406	66
FBXO25	F-box protein 25	0.6369	66
COX7B2	Cytochrome c oxidase subunit 7B2	0.6352	66
SLC26A8	Solute carrier family 26 member 8	0.6322	66
WDR88	WD repeat domain 88	0.6319	66
EXD1	Exonuclease 3'-5' domain containing 1	0.6289	66
C16orf95	Chromosome 16 open reading frame 95	0.6227	66
GOLGA8G	Golgin A8 family member G	0.6198	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	32.3 nTPM
Adipose tissue	33.6 nTPM
Breast	31.0 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	10.0 nTPM
Lung	10.0 nTPM

Astrocytes	25.8 nTPM
Brain	25.8 nTPM

B-cells	24.2 nTPM
Colon	39.9 nTPM
Adipose tissue	36.0 nTPM
PBMC	35.7 nTPM
Liver	25.9 nTPM
Breast	25.5 nTPM
Bone marrow	23.7 nTPM
Stomach	21.8 nTPM
Lymph node	19.1 nTPM
Spleen	14.6 nTPM
Kidney	0.0 nTPM

Dendritic cells	21.4 nTPM
Adipose tissue	29.0 nTPM
Breast	23.3 nTPM
PBMC	12.0 nTPM

Endothelial cells	26.4 nTPM
Prostate	48.2 nTPM
Testis	35.3 nTPM
Lung	31.2 nTPM
Skeletal muscle	29.4 nTPM
Ovary	28.9 nTPM
Pancreas	27.0 nTPM
Eye	26.7 nTPM
Placenta	25.0 nTPM
Skin	23.0 nTPM
Breast	22.1 nTPM
Endometrium	19.2 nTPM
Esophagus	19.0 nTPM
Heart muscle	17.7 nTPM
Liver	17.4 nTPM

Fibroblasts	27.7 nTPM
Adipose tissue	38.5 nTPM
Stomach	35.6 nTPM
Prostate	30.6 nTPM
Heart muscle	30.3 nTPM
Skeletal muscle	29.6 nTPM
Esophagus	29.2 nTPM
Breast	29.1 nTPM
Skin	27.0 nTPM
Ovary	22.6 nTPM
Placenta	20.6 nTPM
Lung	11.1 nTPM

Intestinal goblet cells	18.4 nTPM
Small intestine	21.2 nTPM
Rectum	19.7 nTPM
Colon	14.3 nTPM

Macrophages	22.4 nTPM
Testis	34.9 nTPM
Adipose tissue	28.7 nTPM
Kidney	27.2 nTPM
Bone marrow	26.2 nTPM
Spleen	26.0 nTPM
Lung	24.0 nTPM
Skeletal muscle	23.2 nTPM
Pancreas	23.0 nTPM
Prostate	22.9 nTPM
Ovary	19.6 nTPM
Endometrium	19.1 nTPM
Stomach	17.6 nTPM
Breast	17.0 nTPM
PBMC	13.6 nTPM
Esophagus	12.6 nTPM

Paneth cells	12.0 nTPM
Small intestine	22.5 nTPM
Rectum	10.3 nTPM
Colon	3.3 nTPM

Plasma cells	32.2 nTPM
Spleen	46.7 nTPM
Stomach	42.0 nTPM
Adipose tissue	26.4 nTPM
Esophagus	24.6 nTPM
Bone marrow	21.4 nTPM

Respiratory ciliated cells	75.7 nTPM
Bronchus	78.4 nTPM
Lung	72.9 nTPM

Smooth muscle cells	32.7 nTPM
Pancreas	44.6 nTPM
Prostate	40.7 nTPM
Skeletal muscle	38.8 nTPM
Adipose tissue	36.5 nTPM
Bronchus	33.8 nTPM
Skin	30.3 nTPM
Ovary	29.6 nTPM
Esophagus	29.4 nTPM
Breast	28.8 nTPM
Heart muscle	23.9 nTPM
Endometrium	22.7 nTPM

T-cells	27.2 nTPM
PBMC	38.1 nTPM
Prostate	37.9 nTPM
Adipose tissue	37.3 nTPM
Skeletal muscle	29.1 nTPM
Colon	29.0 nTPM
Ovary	28.9 nTPM
Lung	28.8 nTPM
Lymph node	28.3 nTPM
Kidney	28.0 nTPM
Spleen	27.7 nTPM
Liver	24.3 nTPM
Bone marrow	23.7 nTPM
Stomach	23.6 nTPM
Breast	23.4 nTPM
Skin	21.2 nTPM
Endometrium	20.3 nTPM
Esophagus	13.1 nTPM

Basal keratinocytes	11.2 nTPM
Skin	11.2 nTPM

Basal prostatic cells	36.2 nTPM
Prostate	36.2 nTPM

Basal respiratory cells	41.4 nTPM
Bronchus	41.4 nTPM

Basal squamous epithelial cells	17.1 nTPM
Esophagus	17.1 nTPM

Undifferentiated cells	10.0 nTPM
Small intestine	11.3 nTPM
Rectum	10.7 nTPM
Colon	8.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC