Single cell type - PHB2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PHB2
Gene descriptionⁱ Full gene name according to HGNC.	Prohibitin 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Translation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PHB2 is part of cluster 32 Non-specific - Translation with confidenceⁱ 1
175 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
EEF1B2	Eukaryotic translation elongation factor 1 beta 2	0.6812	32
RPL7A	Ribosomal protein L7a	0.6654	32
MRPS34	Mitochondrial ribosomal protein S34	0.6643	39
NLE1	Notchless homolog 1	0.6632	39
DDX54	DEAD-box helicase 54	0.6560	39
EIF5A	Eukaryotic translation initiation factor 5A	0.6472	39
MRPL11	Mitochondrial ribosomal protein L11	0.6446	39
TXN2	Thioredoxin 2	0.6315	39
DRG2	Developmentally regulated GTP binding protein 2	0.6163	39
STOML2	Stomatin like 2	0.6137	39
SIGMAR1	Sigma non-opioid intracellular receptor 1	0.6085	33
RPL29	Ribosomal protein L29	0.6056	32
NOB1	NIN1 (RPN12) binding protein 1 homolog	0.6039	32
CDK4	Cyclin dependent kinase 4	0.5994	39
RPL18	Ribosomal protein L18	0.5969	32

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	114.1 nTPM
Breast	137.4 nTPM
Adipose tissue	90.9 nTPM

Alveolar cells type 1	48.1 nTPM
Lung	48.1 nTPM

Alveolar cells type 2	54.8 nTPM
Lung	54.8 nTPM

Astrocytes	14.7 nTPM
Brain	14.7 nTPM

B-cells	155.0 nTPM
Liver	205.0 nTPM
PBMC	189.9 nTPM
Spleen	184.8 nTPM
Lymph node	168.4 nTPM
Bone marrow	165.1 nTPM
Stomach	148.1 nTPM
Colon	139.0 nTPM
Breast	135.0 nTPM
Adipose tissue	128.8 nTPM
Kidney	85.7 nTPM

Basal squamous epithelial cells	191.8 nTPM
Esophagus	191.8 nTPM

Dendritic cells	99.8 nTPM
PBMC	111.6 nTPM
Breast	107.9 nTPM
Adipose tissue	79.9 nTPM

Endothelial cells	86.0 nTPM
Esophagus	129.0 nTPM
Breast	124.1 nTPM
Ovary	118.7 nTPM
Placenta	114.2 nTPM
Prostate	102.6 nTPM
Testis	95.4 nTPM
Liver	92.7 nTPM
Endometrium	80.9 nTPM
Eye	75.2 nTPM
Lung	74.8 nTPM
Skin	65.2 nTPM
Skeletal muscle	64.2 nTPM
Pancreas	50.2 nTPM
Heart muscle	17.2 nTPM

Enteroendocrine cells	100.6 nTPM
Colon	113.7 nTPM
Rectum	87.4 nTPM

Erythroid cells	143.7 nTPM
Bone marrow	185.8 nTPM
Liver	101.5 nTPM

Fibroblasts	97.7 nTPM
Ovary	199.1 nTPM
Placenta	142.4 nTPM
Adipose tissue	121.8 nTPM
Breast	120.8 nTPM
Esophagus	109.3 nTPM
Stomach	89.1 nTPM
Prostate	80.2 nTPM
Skin	66.7 nTPM
Lung	62.6 nTPM
Skeletal muscle	61.6 nTPM
Heart muscle	21.4 nTPM

Intestinal goblet cells	142.7 nTPM
Colon	188.0 nTPM
Small intestine	122.3 nTPM
Rectum	117.9 nTPM

Macrophages	105.0 nTPM
Ovary	156.0 nTPM
Prostate	144.4 nTPM
Spleen	136.9 nTPM
Adipose tissue	136.5 nTPM
Testis	127.3 nTPM
Breast	124.4 nTPM
Bone marrow	121.2 nTPM
Kidney	104.3 nTPM
Stomach	102.5 nTPM
Pancreas	91.9 nTPM
Esophagus	89.7 nTPM
Endometrium	87.5 nTPM
Skeletal muscle	79.9 nTPM
Lung	59.5 nTPM
PBMC	13.6 nTPM

Paneth cells	90.3 nTPM
Rectum	153.4 nTPM
Small intestine	71.4 nTPM
Colon	46.1 nTPM

Plasma cells	145.9 nTPM
Spleen	244.7 nTPM
Bone marrow	194.5 nTPM
Stomach	139.9 nTPM
Esophagus	92.4 nTPM
Adipose tissue	58.0 nTPM

Cholangiocytes	91.5 nTPM
Liver	91.5 nTPM

Collecting duct cells	35.0 nTPM
Kidney	35.0 nTPM

Cone photoreceptor cells	39.6 nTPM
Eye	39.6 nTPM

Cytotrophoblasts	212.9 nTPM
Placenta	212.9 nTPM

Respiratory ciliated cells	40.1 nTPM
Lung	43.7 nTPM
Bronchus	36.6 nTPM

Smooth muscle cells	128.7 nTPM
Ovary	222.0 nTPM
Breast	206.9 nTPM
Pancreas	187.3 nTPM
Bronchus	152.2 nTPM
Adipose tissue	139.7 nTPM
Prostate	112.8 nTPM
Esophagus	102.3 nTPM
Skeletal muscle	89.6 nTPM
Endometrium	86.2 nTPM
Skin	78.8 nTPM
Heart muscle	37.4 nTPM

T-cells	102.9 nTPM
PBMC	156.5 nTPM
Lymph node	154.2 nTPM
Liver	139.0 nTPM
Ovary	135.6 nTPM
Spleen	119.3 nTPM
Stomach	116.4 nTPM
Breast	112.3 nTPM
Bone marrow	109.5 nTPM
Esophagus	104.8 nTPM
Colon	101.7 nTPM
Adipose tissue	92.1 nTPM
Prostate	85.2 nTPM
Kidney	84.2 nTPM
Skeletal muscle	68.9 nTPM
Skin	63.0 nTPM
Endometrium	58.9 nTPM
Lung	47.1 nTPM

Undifferentiated cells	268.5 nTPM
Colon	338.8 nTPM
Small intestine	259.1 nTPM
Rectum	207.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC