Single cell type - DDX3X - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DDX3X
Gene descriptionⁱ Full gene name according to HGNC.	DEAD-box helicase 3 X-linked
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	23

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Mitochondria (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DDX3X is part of cluster 7 Non-specific - Mitochondria with confidenceⁱ 1
481 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SFPQ	Splicing factor proline and glutamine rich	0.6488	7
GTF2B	General transcription factor IIB	0.6290	7
GRK2	G protein-coupled receptor kinase 2	0.6239	7
UBE2S	Ubiquitin conjugating enzyme E2 S	0.6152	7
NUFIP2	Nuclear FMR1 interacting protein 2	0.6022	7
IER5L	Immediate early response 5 like	0.5958	7
IQCN	IQ motif containing N	0.5947	7
FUS	FUS RNA binding protein	0.5929	7
PPP1R10	Protein phosphatase 1 regulatory subunit 10	0.5872	7
POLR2A	RNA polymerase II subunit A	0.5871	7
HBP1	HMG-box transcription factor 1	0.5851	25
DNAJA1	DnaJ heat shock protein family (Hsp40) member A1	0.5832	7
CFAP97D1	CFAP97 domain containing 1	0.5826	7
JUNB	JunB proto-oncogene, AP-1 transcription factor subunit	0.5767	7
INTS6	Integrator complex subunit 6	0.5732	7

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	466.5 nTPM
Adipose tissue	530.3 nTPM
Breast	402.7 nTPM

Alveolar cells type 1	86.6 nTPM
Lung	86.6 nTPM

Alveolar cells type 2	150.0 nTPM
Lung	150.0 nTPM

Astrocytes	66.9 nTPM
Brain	66.9 nTPM

B-cells	280.1 nTPM
Adipose tissue	824.2 nTPM
Breast	556.3 nTPM
Lymph node	405.7 nTPM
Stomach	250.2 nTPM
Spleen	217.4 nTPM
Colon	212.4 nTPM
Kidney	109.5 nTPM
Liver	101.0 nTPM
Bone marrow	66.2 nTPM
PBMC	58.6 nTPM

Basal squamous epithelial cells	191.8 nTPM
Esophagus	191.8 nTPM

Dendritic cells	415.2 nTPM
Adipose tissue	601.1 nTPM
Breast	600.7 nTPM
PBMC	43.8 nTPM

Endothelial cells	238.5 nTPM
Skeletal muscle	426.6 nTPM
Breast	382.3 nTPM
Endometrium	347.5 nTPM
Skin	312.7 nTPM
Prostate	288.1 nTPM
Eye	280.8 nTPM
Esophagus	264.2 nTPM
Heart muscle	202.2 nTPM
Ovary	192.9 nTPM
Liver	160.5 nTPM
Lung	143.5 nTPM
Placenta	131.9 nTPM
Testis	120.6 nTPM
Pancreas	84.9 nTPM

Enteroendocrine cells	183.7 nTPM
Colon	209.6 nTPM
Rectum	157.8 nTPM

Erythroid cells	113.0 nTPM
Liver	160.4 nTPM
Bone marrow	65.6 nTPM

Fibroblasts	191.8 nTPM
Adipose tissue	290.5 nTPM
Breast	260.1 nTPM
Stomach	230.2 nTPM
Skin	224.3 nTPM
Prostate	209.3 nTPM
Skeletal muscle	183.4 nTPM
Lung	178.7 nTPM
Esophagus	173.2 nTPM
Heart muscle	168.2 nTPM
Ovary	120.9 nTPM
Placenta	70.5 nTPM

Intestinal goblet cells	161.4 nTPM
Colon	209.4 nTPM
Rectum	147.0 nTPM
Small intestine	127.9 nTPM

Macrophages	319.0 nTPM
Adipose tissue	974.2 nTPM
Breast	596.9 nTPM
Stomach	424.9 nTPM
Skeletal muscle	410.7 nTPM
Spleen	404.3 nTPM
Endometrium	383.7 nTPM
Esophagus	357.2 nTPM
Prostate	208.6 nTPM
Ovary	201.0 nTPM
Kidney	192.0 nTPM
Bone marrow	183.7 nTPM
Testis	160.9 nTPM
Lung	142.6 nTPM
Pancreas	117.4 nTPM
PBMC	27.3 nTPM

Paneth cells	156.7 nTPM
Rectum	171.0 nTPM
Small intestine	154.0 nTPM
Colon	145.0 nTPM

Plasma cells	241.8 nTPM
Adipose tissue	527.7 nTPM
Esophagus	233.9 nTPM
Stomach	219.5 nTPM
Spleen	123.8 nTPM
Bone marrow	103.8 nTPM

Cholangiocytes	81.5 nTPM
Liver	81.5 nTPM

Collecting duct cells	58.8 nTPM
Kidney	58.8 nTPM

Cone photoreceptor cells	131.3 nTPM
Eye	131.3 nTPM

Cytotrophoblasts	94.6 nTPM
Placenta	94.6 nTPM

Respiratory ciliated cells	102.5 nTPM
Bronchus	133.5 nTPM
Lung	71.4 nTPM

Smooth muscle cells	210.1 nTPM
Adipose tissue	344.5 nTPM
Prostate	274.5 nTPM
Breast	263.1 nTPM
Skeletal muscle	247.2 nTPM
Endometrium	245.2 nTPM
Skin	210.7 nTPM
Esophagus	195.4 nTPM
Ovary	195.2 nTPM
Heart muscle	151.0 nTPM
Bronchus	127.7 nTPM
Pancreas	57.2 nTPM

T-cells	342.4 nTPM
Breast	936.0 nTPM
Adipose tissue	855.3 nTPM
Endometrium	712.7 nTPM
Skeletal muscle	535.1 nTPM
Lymph node	399.9 nTPM
Ovary	380.4 nTPM
Colon	256.6 nTPM
Stomach	254.9 nTPM
Spleen	236.7 nTPM
Esophagus	229.3 nTPM
Skin	220.6 nTPM
Prostate	203.6 nTPM
Liver	156.5 nTPM
Lung	139.8 nTPM
Kidney	134.9 nTPM
Bone marrow	86.0 nTPM
PBMC	83.4 nTPM

Undifferentiated cells	129.1 nTPM
Colon	155.8 nTPM
Rectum	128.5 nTPM
Small intestine	102.9 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC