Single cell type - PIGBOS1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PIGBOS1
Gene descriptionⁱ Full gene name according to HGNC.	PIGB opposite strand 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PIGBOS1 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 1
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
LSM8	LSM8 homolog, U6 small nuclear RNA associated	0.5845	32
PYM1	PYM homolog 1, exon junction complex associated factor	0.5702	39
ALKBH4	AlkB homolog 4, lysine demethylase	0.5559	39
HDDC3	HD domain containing 3	0.5439	39
ZNF22	Zinc finger protein 22	0.5231	32
GPALPP1	GPALPP motifs containing 1	0.5102	52
SEC22B	SEC22 homolog B, vesicle trafficking protein	0.4985	46
PSMA2	Proteasome 20S subunit alpha 2	0.4946	3
HSCB	HscB mitochondrial iron-sulfur cluster cochaperone	0.4939	39
RBM43	RNA binding motif protein 43	0.4926	50
ING4	Inhibitor of growth family member 4	0.4879	63
C12orf43	Chromosome 12 open reading frame 43	0.4876	63
NCKAP1L	NCK associated protein 1 like	0.4851	4
TYW3	TRNA-yW synthesizing protein 3 homolog	0.4842	39
BOLA1	BolA family member 1	0.4832	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.0 nTPM
Breast	22.9 nTPM
Adipose tissue	17.1 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	21.6 nTPM
Lung	21.6 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	24.8 nTPM
Kidney	57.1 nTPM
PBMC	47.1 nTPM
Liver	32.3 nTPM
Bone marrow	25.3 nTPM
Stomach	16.4 nTPM
Colon	16.0 nTPM
Breast	16.0 nTPM
Spleen	14.9 nTPM
Adipose tissue	14.6 nTPM
Lymph node	8.7 nTPM

Dendritic cells	34.0 nTPM
PBMC	59.8 nTPM
Adipose tissue	23.7 nTPM
Breast	18.6 nTPM

Endothelial cells	22.5 nTPM
Pancreas	42.5 nTPM
Liver	37.6 nTPM
Placenta	32.4 nTPM
Heart muscle	29.7 nTPM
Testis	25.8 nTPM
Esophagus	23.2 nTPM
Ovary	22.3 nTPM
Breast	20.4 nTPM
Endometrium	17.6 nTPM
Skeletal muscle	17.1 nTPM
Eye	17.0 nTPM
Prostate	16.7 nTPM
Lung	12.5 nTPM
Skin	0.0 nTPM

Fibroblasts	21.7 nTPM
Placenta	35.1 nTPM
Adipose tissue	31.4 nTPM
Stomach	31.2 nTPM
Breast	28.0 nTPM
Esophagus	26.9 nTPM
Skeletal muscle	22.4 nTPM
Ovary	21.7 nTPM
Prostate	19.8 nTPM
Lung	13.4 nTPM
Heart muscle	8.9 nTPM
Skin	0.0 nTPM

Intestinal goblet cells	18.5 nTPM
Colon	19.3 nTPM
Small intestine	18.9 nTPM
Rectum	17.4 nTPM

Macrophages	21.9 nTPM
Kidney	40.9 nTPM
Testis	40.1 nTPM
Lung	33.2 nTPM
Pancreas	30.7 nTPM
Ovary	29.3 nTPM
Breast	22.4 nTPM
Bone marrow	20.0 nTPM
Prostate	19.5 nTPM
Endometrium	19.1 nTPM
Skeletal muscle	19.0 nTPM
Stomach	14.7 nTPM
Esophagus	14.2 nTPM
Adipose tissue	12.6 nTPM
Spleen	12.5 nTPM
PBMC	0.0 nTPM

Paneth cells	22.5 nTPM
Small intestine	41.3 nTPM
Rectum	19.5 nTPM
Colon	6.5 nTPM

Plasma cells	19.6 nTPM
Stomach	30.0 nTPM
Bone marrow	23.0 nTPM
Spleen	21.4 nTPM
Esophagus	18.4 nTPM
Adipose tissue	5.2 nTPM

Respiratory ciliated cells	19.0 nTPM
Lung	37.9 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	16.3 nTPM
Esophagus	26.4 nTPM
Pancreas	25.9 nTPM
Ovary	23.3 nTPM
Heart muscle	20.9 nTPM
Breast	18.7 nTPM
Adipose tissue	17.2 nTPM
Skeletal muscle	16.1 nTPM
Endometrium	15.8 nTPM
Prostate	14.7 nTPM
Skin	0.0 nTPM
Bronchus	0.0 nTPM

T-cells	19.7 nTPM
PBMC	46.4 nTPM
Liver	36.3 nTPM
Lung	33.4 nTPM
Ovary	33.3 nTPM
Kidney	24.7 nTPM
Bone marrow	21.7 nTPM
Colon	19.5 nTPM
Endometrium	16.4 nTPM
Stomach	15.9 nTPM
Adipose tissue	14.6 nTPM
Skeletal muscle	14.4 nTPM
Prostate	14.2 nTPM
Esophagus	13.1 nTPM
Breast	12.3 nTPM
Spleen	10.9 nTPM
Lymph node	7.8 nTPM
Skin	0.0 nTPM

Basal squamous epithelial cells	14.8 nTPM
Esophagus	14.8 nTPM

Cholangiocytes	14.3 nTPM
Liver	14.3 nTPM

Cone photoreceptor cells	6.2 nTPM
Eye	6.2 nTPM

Distal tubular cells	39.2 nTPM
Kidney	39.2 nTPM

Undifferentiated cells	15.3 nTPM
Small intestine	19.6 nTPM
Rectum	16.0 nTPM
Colon	10.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC