Single cell type - ACBD6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACBD6
Gene descriptionⁱ Full gene name according to HGNC.	Acyl-CoA binding domain containing 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cytotrophoblasts - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ACBD6 is part of cluster 47 Cytotrophoblasts - Unknown function with confidenceⁱ 1
226 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SLC35B4	Solute carrier family 35 member B4	0.5998	47
PAK6	P21 (RAC1) activated kinase 6	0.5916	47
EXTL2	Exostosin like glycosyltransferase 2	0.5823	47
AMELY	Amelogenin Y-linked	0.5750	47
ISYNA1	Inositol-3-phosphate synthase 1	0.5740	47
VSTM5	V-set and transmembrane domain containing 5	0.5585	47
SMIM43	Small integral membrane protein 43	0.5572	47
PISD	Phosphatidylserine decarboxylase	0.5551	47
MANSC4	MANSC domain containing 4	0.5519	47
SOX14	SRY-box transcription factor 14	0.5517	47
PAGE4	PAGE family member 4	0.5455	47
ADRB1	Adrenoceptor beta 1	0.5436	47
TRBV20OR9-2	T cell receptor beta variable 20/OR9-2 (non-functional)	0.5417	47
MYORG	Myogenesis regulating glycosidase (putative)	0.5334	47
FBN2	Fibrillin 2	0.5308	47

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	31.5 nTPM
Breast	33.4 nTPM
Adipose tissue	29.7 nTPM

Alveolar cells type 1	32.1 nTPM
Lung	32.1 nTPM

Alveolar cells type 2	33.0 nTPM
Lung	33.0 nTPM

Astrocytes	60.4 nTPM
Brain	60.4 nTPM

B-cells	32.7 nTPM
Liver	46.3 nTPM
Spleen	46.1 nTPM
Lymph node	44.2 nTPM
Stomach	40.0 nTPM
Bone marrow	35.1 nTPM
Adipose tissue	33.6 nTPM
Breast	30.7 nTPM
Kidney	28.5 nTPM
PBMC	22.8 nTPM
Colon	0.0 nTPM

Dendritic cells	38.7 nTPM
PBMC	51.8 nTPM
Breast	35.0 nTPM
Adipose tissue	29.3 nTPM

Endothelial cells	31.9 nTPM
Pancreas	46.4 nTPM
Placenta	46.0 nTPM
Ovary	43.5 nTPM
Esophagus	41.4 nTPM
Eye	38.8 nTPM
Testis	33.2 nTPM
Endometrium	29.0 nTPM
Breast	27.0 nTPM
Skeletal muscle	26.2 nTPM
Prostate	25.0 nTPM
Lung	24.9 nTPM
Skin	24.4 nTPM
Liver	22.9 nTPM
Heart muscle	18.1 nTPM

Fibroblasts	35.6 nTPM
Adipose tissue	52.3 nTPM
Ovary	52.1 nTPM
Placenta	47.6 nTPM
Stomach	35.6 nTPM
Skeletal muscle	35.3 nTPM
Breast	33.3 nTPM
Esophagus	33.1 nTPM
Skin	30.6 nTPM
Prostate	28.0 nTPM
Lung	23.4 nTPM
Heart muscle	20.5 nTPM

Intestinal goblet cells	15.7 nTPM
Rectum	24.4 nTPM
Small intestine	22.6 nTPM
Colon	0.0 nTPM

Macrophages	25.0 nTPM
Testis	37.8 nTPM
Ovary	35.0 nTPM
Breast	32.6 nTPM
Adipose tissue	31.6 nTPM
Lung	30.2 nTPM
Kidney	28.7 nTPM
Prostate	27.5 nTPM
Endometrium	25.3 nTPM
Skeletal muscle	25.1 nTPM
Pancreas	23.0 nTPM
Esophagus	22.0 nTPM
Spleen	19.7 nTPM
Bone marrow	18.8 nTPM
Stomach	17.6 nTPM
PBMC	0.0 nTPM

Paneth cells	12.9 nTPM
Rectum	23.9 nTPM
Small intestine	15.0 nTPM
Colon	0.0 nTPM

Plasma cells	48.4 nTPM
Spleen	67.5 nTPM
Bone marrow	57.7 nTPM
Stomach	44.5 nTPM
Esophagus	43.0 nTPM
Adipose tissue	29.1 nTPM

Respiratory ciliated cells	27.4 nTPM
Lung	37.9 nTPM
Bronchus	17.0 nTPM

Smooth muscle cells	53.4 nTPM
Bronchus	204.1 nTPM
Ovary	66.1 nTPM
Pancreas	51.8 nTPM
Breast	38.5 nTPM
Adipose tissue	37.4 nTPM
Endometrium	35.3 nTPM
Skeletal muscle	34.7 nTPM
Skin	32.7 nTPM
Esophagus	31.0 nTPM
Heart muscle	27.9 nTPM
Prostate	27.8 nTPM

T-cells	29.4 nTPM
Ovary	44.5 nTPM
Lymph node	41.9 nTPM
PBMC	38.1 nTPM
Skeletal muscle	36.6 nTPM
Bone marrow	36.3 nTPM
Adipose tissue	33.9 nTPM
Breast	33.1 nTPM
Spleen	32.4 nTPM
Kidney	31.5 nTPM
Stomach	31.3 nTPM
Endometrium	29.8 nTPM
Lung	27.4 nTPM
Liver	25.0 nTPM
Skin	24.9 nTPM
Esophagus	19.7 nTPM
Prostate	14.2 nTPM
Colon	0.0 nTPM

Basal keratinocytes	21.3 nTPM
Skin	21.3 nTPM

Basal prostatic cells	29.9 nTPM
Prostate	29.9 nTPM

Basal squamous epithelial cells	42.7 nTPM
Esophagus	42.7 nTPM

Cholangiocytes	21.5 nTPM
Liver	21.5 nTPM

Undifferentiated cells	19.2 nTPM
Small intestine	31.4 nTPM
Rectum	26.1 nTPM
Colon	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC