Single cell type - TAPBP - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TAPBP
Gene descriptionⁱ Full gene name according to HGNC.	TAP binding protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Pancreatic cells - Digestion (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CAPAN-2, Karpas-707, U-266/70)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TAPBP is part of cluster 1 Pancreatic cells - Digestion with confidenceⁱ 1
148 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ERAP2	Endoplasmic reticulum aminopeptidase 2	0.5857	63
SLC35C1	Solute carrier family 35 member C1	0.5531	27
PSMB8	Proteasome 20S subunit beta 8	0.5343	63
HLA-F	Major histocompatibility complex, class I, F	0.5319	63
PRKD2	Protein kinase D2	0.5315	57
DUOXA2	Dual oxidase maturation factor 2	0.5211	1
REG3G	Regenerating family member 3 gamma	0.5120	1
HPS6	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3	0.5105	47
NLRC5	NLR family CARD domain containing 5	0.5094	63
HLA-B	Major histocompatibility complex, class I, B	0.5023	63
HTR3A	5-hydroxytryptamine receptor 3A	0.4910	1
HLA-A	Major histocompatibility complex, class I, A	0.4878	63
KHNYN	KH and NYN domain containing	0.4872	27
TAP1	Transporter 1, ATP binding cassette subfamily B member	0.4853	63
CCDC97	Coiled-coil domain containing 97	0.4816	24

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	116.8 nTPM
Adipose tissue	141.8 nTPM
Breast	91.8 nTPM

Alveolar cells type 1	125.0 nTPM
Lung	125.0 nTPM

Alveolar cells type 2	102.1 nTPM
Lung	102.1 nTPM

Astrocytes	22.5 nTPM
Brain	22.5 nTPM

B-cells	186.6 nTPM
Adipose tissue	254.1 nTPM
Kidney	219.0 nTPM
Colon	204.4 nTPM
PBMC	198.5 nTPM
Lymph node	182.4 nTPM
Spleen	179.9 nTPM
Liver	177.6 nTPM
Stomach	170.3 nTPM
Bone marrow	151.2 nTPM
Breast	128.4 nTPM

Dendritic cells	223.7 nTPM
Adipose tissue	270.8 nTPM
PBMC	211.2 nTPM
Breast	189.2 nTPM

Endothelial cells	99.1 nTPM
Ovary	145.0 nTPM
Heart muscle	128.6 nTPM
Skin	123.9 nTPM
Prostate	114.1 nTPM
Skeletal muscle	111.6 nTPM
Pancreas	108.1 nTPM
Endometrium	103.6 nTPM
Esophagus	100.8 nTPM
Breast	96.2 nTPM
Placenta	78.4 nTPM
Testis	74.7 nTPM
Liver	74.3 nTPM
Eye	72.0 nTPM
Lung	56.1 nTPM

Fibroblasts	63.9 nTPM
Adipose tissue	87.1 nTPM
Prostate	77.5 nTPM
Skin	76.8 nTPM
Stomach	71.3 nTPM
Esophagus	65.1 nTPM
Breast	63.6 nTPM
Lung	58.1 nTPM
Heart muscle	56.0 nTPM
Skeletal muscle	55.7 nTPM
Ovary	50.4 nTPM
Placenta	41.3 nTPM

Intestinal goblet cells	174.6 nTPM
Colon	206.6 nTPM
Small intestine	186.7 nTPM
Rectum	130.7 nTPM

Macrophages	131.9 nTPM
Pancreas	206.7 nTPM
Adipose tissue	202.5 nTPM
Stomach	167.0 nTPM
Spleen	150.3 nTPM
Endometrium	148.7 nTPM
Bone marrow	148.7 nTPM
Ovary	139.0 nTPM
Kidney	132.4 nTPM
Skeletal muscle	126.9 nTPM
Lung	122.8 nTPM
Prostate	118.1 nTPM
Breast	109.0 nTPM
Esophagus	103.9 nTPM
Testis	75.0 nTPM
PBMC	27.3 nTPM

Paneth cells	172.4 nTPM
Small intestine	199.0 nTPM
Colon	187.7 nTPM
Rectum	130.4 nTPM

Plasma cells	194.9 nTPM
Stomach	275.9 nTPM
Adipose tissue	236.7 nTPM
Esophagus	166.4 nTPM
Spleen	156.9 nTPM
Bone marrow	138.5 nTPM

Respiratory ciliated cells	113.3 nTPM
Bronchus	165.4 nTPM
Lung	61.2 nTPM

Smooth muscle cells	57.6 nTPM
Pancreas	92.3 nTPM
Adipose tissue	77.6 nTPM
Breast	61.9 nTPM
Skin	61.7 nTPM
Skeletal muscle	61.3 nTPM
Heart muscle	53.0 nTPM
Ovary	52.4 nTPM
Bronchus	50.0 nTPM
Prostate	49.7 nTPM
Endometrium	45.7 nTPM
Esophagus	27.9 nTPM

T-cells	163.7 nTPM
Bone marrow	205.8 nTPM
Spleen	202.1 nTPM
Adipose tissue	190.5 nTPM
Colon	182.0 nTPM
Kidney	180.0 nTPM
Stomach	173.6 nTPM
PBMC	167.7 nTPM
Lymph node	167.7 nTPM
Liver	164.5 nTPM
Skeletal muscle	162.6 nTPM
Endometrium	157.7 nTPM
Esophagus	157.2 nTPM
Lung	156.4 nTPM
Ovary	151.2 nTPM
Breast	148.9 nTPM
Skin	134.0 nTPM
Prostate	80.4 nTPM

Basal keratinocytes	77.0 nTPM
Skin	77.0 nTPM

Basal prostatic cells	93.3 nTPM
Prostate	93.3 nTPM

Basal respiratory cells	148.2 nTPM
Bronchus	148.2 nTPM

Basal squamous epithelial cells	66.6 nTPM
Esophagus	66.6 nTPM

Undifferentiated cells	162.3 nTPM
Colon	238.4 nTPM
Small intestine	138.4 nTPM
Rectum	110.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC