Single cell type - GPX1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GPX1
Gene descriptionⁱ Full gene name according to HGNC.	Glutathione peroxidase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Myeloid cells - Hemostasis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells, Hofbauer cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Kupffer cells, Hofbauer cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GPX1 is part of cluster 51 Myeloid cells - Hemostasis with confidenceⁱ 1
155 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NCOA4	Nuclear receptor coactivator 4	0.7283	51
RGS10	Regulator of G protein signaling 10	0.7151	51
F13A1	Coagulation factor XIII A chain	0.6997	4
LAMTOR1	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 1	0.6983	51
FERMT3	Fermitin family member 3	0.6979	51
LGALS12	Galectin 12	0.6964	51
ITGB3	Integrin subunit beta 3	0.6824	51
PPBP	Pro-platelet basic protein	0.6809	51
RGS18	Regulator of G protein signaling 18	0.6801	51
ARPC1B	Actin related protein 2/3 complex subunit 1B	0.6779	51
PTCRA	Pre T cell antigen receptor alpha	0.6751	51
TUBB1	Tubulin beta 1 class VI	0.6742	51
CLEC1B	C-type lectin domain family 1 member B	0.6738	51
HBG2	Hemoglobin subunit gamma 2	0.6721	51
GP9	Glycoprotein IX platelet	0.6719	51

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Alveolar cells type 1	109.0 nTPM
Lung	109.0 nTPM

Alveolar cells type 2	323.5 nTPM
Lung	323.5 nTPM

Astrocytes	6.2 nTPM
Brain	6.2 nTPM

B-cells	148.1 nTPM
Liver	489.8 nTPM
PBMC	325.4 nTPM
Colon	293.9 nTPM
Lymph node	137.4 nTPM
Bone marrow	99.7 nTPM
Spleen	75.8 nTPM
Stomach	59.5 nTPM
Kidney	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	491.5 nTPM
PBMC	1474.4 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Endothelial cells	227.8 nTPM
Eye	784.9 nTPM
Prostate	495.4 nTPM
Placenta	448.5 nTPM
Skin	446.7 nTPM
Liver	291.7 nTPM
Skeletal muscle	213.7 nTPM
Testis	213.3 nTPM
Lung	190.3 nTPM
Esophagus	104.9 nTPM
Heart muscle	0.0 nTPM
Pancreas	0.0 nTPM
Endometrium	0.0 nTPM
Ovary	0.0 nTPM
Breast	0.0 nTPM

Enteroendocrine cells	251.3 nTPM
Colon	284.2 nTPM
Rectum	218.4 nTPM

Erythroid cells	364.1 nTPM
Liver	561.7 nTPM
Bone marrow	166.5 nTPM

Fibroblasts	131.0 nTPM
Placenta	375.3 nTPM
Skin	329.3 nTPM
Prostate	299.9 nTPM
Lung	194.3 nTPM
Skeletal muscle	114.6 nTPM
Esophagus	65.2 nTPM
Stomach	62.4 nTPM
Heart muscle	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Intestinal goblet cells	285.0 nTPM
Colon	398.0 nTPM
Rectum	252.5 nTPM
Small intestine	204.5 nTPM

Macrophages	1305.5 nTPM
PBMC	8197.9 nTPM
Prostate	3958.4 nTPM
Testis	3371.2 nTPM
Skeletal muscle	924.9 nTPM
Lung	914.9 nTPM
Spleen	701.0 nTPM
Bone marrow	693.5 nTPM
Esophagus	454.8 nTPM
Stomach	366.3 nTPM
Kidney	0.0 nTPM
Pancreas	0.0 nTPM
Endometrium	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Paneth cells	179.0 nTPM
Rectum	237.3 nTPM
Small intestine	161.5 nTPM
Colon	138.3 nTPM

Plasma cells	82.4 nTPM
Bone marrow	148.3 nTPM
Spleen	120.9 nTPM
Stomach	87.1 nTPM
Esophagus	55.5 nTPM
Adipose tissue	0.0 nTPM

Respiratory ciliated cells	490.0 nTPM
Bronchus	754.1 nTPM
Lung	225.9 nTPM

Basal keratinocytes	249.7 nTPM
Skin	249.7 nTPM

Basal prostatic cells	432.8 nTPM
Prostate	432.8 nTPM

Basal respiratory cells	985.0 nTPM
Bronchus	985.0 nTPM

Basal squamous epithelial cells	92.2 nTPM
Esophagus	92.2 nTPM

Smooth muscle cells	151.8 nTPM
Bronchus	1040.1 nTPM
Skin	234.0 nTPM
Prostate	230.7 nTPM
Skeletal muscle	132.4 nTPM
Esophagus	32.5 nTPM
Heart muscle	0.0 nTPM
Pancreas	0.0 nTPM
Endometrium	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

T-cells	112.2 nTPM
Prostate	383.5 nTPM
Lung	281.0 nTPM
Skin	274.9 nTPM
Liver	188.7 nTPM
PBMC	178.6 nTPM
Colon	170.1 nTPM
Skeletal muscle	101.0 nTPM
Esophagus	85.2 nTPM
Lymph node	73.1 nTPM
Spleen	67.7 nTPM
Bone marrow	56.4 nTPM
Stomach	46.9 nTPM
Kidney	0.0 nTPM
Endometrium	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Breast	0.0 nTPM

Undifferentiated cells	367.3 nTPM
Colon	466.9 nTPM
Small intestine	338.6 nTPM
Rectum	296.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC