Single cell type - ZBED5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZBED5
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger BED-type containing 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZBED5 is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZNF141	Zinc finger protein 141	0.5639	57
ZNF441	Zinc finger protein 441	0.5537	43
IGHV1-58	Immunoglobulin heavy variable 1-58	0.5461	57
IGHV2-26	Immunoglobulin heavy variable 2-26	0.5318	57
LCN10	Lipocalin 10	0.5313	57
RRAGB	Ras related GTP binding B	0.5286	52
PAX5	Paired box 5	0.5279	57
ZNF860	Zinc finger protein 860	0.5186	57
CHI3L2	Chitinase 3 like 2	0.5186	57
CR2	Complement C3d receptor 2	0.5175	57
FCRL1	Fc receptor like 1	0.5173	57
EPM2AIP1	EPM2A interacting protein 1	0.5160	52
ZNF107	Zinc finger protein 107	0.5154	57
ZNF627	Zinc finger protein 627	0.5114	57
FCER2	Fc fragment of IgE receptor II	0.5092	57

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.1 nTPM
Adipose tissue	20.3 nTPM
Breast	13.9 nTPM

Alveolar cells type 1	57.7 nTPM
Lung	57.7 nTPM

Alveolar cells type 2	33.0 nTPM
Lung	33.0 nTPM

Astrocytes	32.0 nTPM
Brain	32.0 nTPM

Basal keratinocytes	34.7 nTPM
Skin	34.7 nTPM

B-cells	44.6 nTPM
Bone marrow	65.4 nTPM
Lymph node	64.5 nTPM
Spleen	59.1 nTPM
PBMC	54.3 nTPM
Adipose tissue	53.6 nTPM
Stomach	50.4 nTPM
Colon	33.5 nTPM
Kidney	33.4 nTPM
Liver	19.5 nTPM
Breast	12.1 nTPM

Dendritic cells	13.6 nTPM
PBMC	16.0 nTPM
Adipose tissue	14.7 nTPM
Breast	10.2 nTPM

Endothelial cells	22.7 nTPM
Heart muscle	51.6 nTPM
Esophagus	32.1 nTPM
Breast	28.8 nTPM
Lung	28.1 nTPM
Skeletal muscle	25.3 nTPM
Testis	21.0 nTPM
Endometrium	20.9 nTPM
Prostate	19.0 nTPM
Ovary	18.3 nTPM
Eye	17.8 nTPM
Liver	16.5 nTPM
Placenta	16.5 nTPM
Skin	14.3 nTPM
Pancreas	7.7 nTPM

Fibroblasts	27.3 nTPM
Esophagus	51.5 nTPM
Lung	33.5 nTPM
Stomach	31.2 nTPM
Skeletal muscle	30.8 nTPM
Adipose tissue	28.1 nTPM
Heart muscle	27.9 nTPM
Prostate	25.3 nTPM
Breast	20.0 nTPM
Skin	19.5 nTPM
Ovary	16.3 nTPM
Placenta	15.6 nTPM

Intestinal goblet cells	15.6 nTPM
Rectum	20.0 nTPM
Small intestine	15.3 nTPM
Colon	11.4 nTPM

Macrophages	19.3 nTPM
Lung	32.3 nTPM
Stomach	32.2 nTPM
Skeletal muscle	27.8 nTPM
Endometrium	26.0 nTPM
Esophagus	23.6 nTPM
Spleen	20.7 nTPM
Adipose tissue	20.4 nTPM
Kidney	19.6 nTPM
Testis	19.2 nTPM
Bone marrow	17.5 nTPM
Prostate	16.0 nTPM
Ovary	12.6 nTPM
Breast	11.3 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	13.1 nTPM
Rectum	20.5 nTPM
Small intestine	18.8 nTPM
Colon	0.0 nTPM

Plasma cells	26.6 nTPM
Esophagus	43.0 nTPM
Bone marrow	28.0 nTPM
Spleen	23.2 nTPM
Stomach	19.9 nTPM
Adipose tissue	18.8 nTPM

Respiratory ciliated cells	42.7 nTPM
Lung	61.2 nTPM
Bronchus	24.2 nTPM

Smooth muscle cells	25.2 nTPM
Esophagus	46.5 nTPM
Heart muscle	42.8 nTPM
Endometrium	29.3 nTPM
Adipose tissue	28.2 nTPM
Prostate	27.2 nTPM
Skeletal muscle	26.4 nTPM
Skin	23.7 nTPM
Ovary	18.7 nTPM
Pancreas	13.5 nTPM
Breast	10.7 nTPM
Bronchus	10.3 nTPM

Collecting duct cells	22.0 nTPM
Kidney	22.0 nTPM

Cone photoreceptor cells	29.2 nTPM
Eye	29.2 nTPM

Distal enterocytes	12.3 nTPM
Rectum	15.1 nTPM
Colon	9.4 nTPM

Distal tubular cells	23.5 nTPM
Kidney	23.5 nTPM

T-cells	22.6 nTPM
Lymph node	47.1 nTPM
Lung	38.0 nTPM
Bone marrow	31.7 nTPM
PBMC	30.9 nTPM
Prostate	28.4 nTPM
Spleen	28.1 nTPM
Liver	27.3 nTPM
Endometrium	23.7 nTPM
Stomach	21.6 nTPM
Kidney	18.5 nTPM
Skeletal muscle	17.7 nTPM
Skin	16.1 nTPM
Adipose tissue	15.5 nTPM
Colon	11.9 nTPM
Breast	11.7 nTPM
Ovary	8.9 nTPM
Esophagus	6.6 nTPM

Undifferentiated cells	16.7 nTPM
Rectum	20.7 nTPM
Small intestine	16.4 nTPM
Colon	13.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC