Single cell type - RNF103 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RNF103
Gene descriptionⁱ Full gene name according to HGNC.	Ring finger protein 103
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Glandular cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (eosinophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

RNF103 is part of cluster 35 Glandular cells - Unknown function with confidenceⁱ 1
101 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
WASL	WASP like actin nucleation promoting factor	0.5262	53
PNPLA2	Patatin like phospholipase domain containing 2	0.5180	53
CHAD	Chondroadherin	0.5147	27
CDKN1A	Cyclin dependent kinase inhibitor 1A	0.5119	7
TMEM59	Transmembrane protein 59	0.5038	26
SMIM14	Small integral membrane protein 14	0.4986	2
GUCD1	Guanylyl cyclase domain containing 1	0.4890	45
KRTAP13-2	Keratin associated protein 13-2	0.4741	53
RMND5A	Required for meiotic nuclear division 5 homolog A	0.4715	6
MSMB	Microseminoprotein beta	0.4679	35
GTPBP1	GTP binding protein 1	0.4631	22
IFNLR1	Interferon lambda receptor 1	0.4624	22
RAB5B	RAB5B, member RAS oncogene family	0.4605	22
TSPAN3	Tetraspanin 3	0.4586	53
KLK2	Kallikrein related peptidase 2	0.4500	35

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.6 nTPM
Adipose tissue	28.3 nTPM
Breast	16.8 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	14.5 nTPM
Lung	14.5 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	16.6 nTPM
Lymph node	47.4 nTPM
Adipose tissue	22.1 nTPM
Breast	18.7 nTPM
Stomach	16.8 nTPM
Spleen	15.6 nTPM
Colon	14.4 nTPM
Liver	11.0 nTPM
Bone marrow	8.1 nTPM
PBMC	7.1 nTPM
Kidney	4.8 nTPM

Dendritic cells	15.7 nTPM
Adipose tissue	24.9 nTPM
Breast	18.2 nTPM
PBMC	4.0 nTPM

Endothelial cells	22.4 nTPM
Prostate	39.0 nTPM
Esophagus	34.6 nTPM
Skin	33.8 nTPM
Pancreas	27.0 nTPM
Breast	25.2 nTPM
Skeletal muscle	25.0 nTPM
Liver	22.9 nTPM
Endometrium	19.8 nTPM
Ovary	17.5 nTPM
Placenta	15.9 nTPM
Lung	15.6 nTPM
Heart muscle	14.8 nTPM
Eye	12.9 nTPM
Testis	9.8 nTPM

Fibroblasts	27.6 nTPM
Skin	54.4 nTPM
Prostate	38.8 nTPM
Adipose tissue	35.1 nTPM
Esophagus	34.5 nTPM
Heart muscle	32.6 nTPM
Skeletal muscle	30.6 nTPM
Breast	23.6 nTPM
Stomach	22.3 nTPM
Placenta	14.5 nTPM
Ovary	12.0 nTPM
Lung	5.6 nTPM

Intestinal goblet cells	45.9 nTPM
Small intestine	57.6 nTPM
Rectum	50.2 nTPM
Colon	30.0 nTPM

Macrophages	19.8 nTPM
Adipose tissue	45.2 nTPM
Esophagus	44.1 nTPM
Prostate	33.2 nTPM
Stomach	32.2 nTPM
Spleen	32.1 nTPM
Breast	22.9 nTPM
Ovary	17.0 nTPM
Endometrium	16.7 nTPM
Skeletal muscle	16.7 nTPM
Testis	14.5 nTPM
Bone marrow	8.7 nTPM
Lung	7.3 nTPM
Kidney	6.8 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM

Paneth cells	41.5 nTPM
Colon	52.6 nTPM
Small intestine	41.3 nTPM
Rectum	30.6 nTPM

Plasma cells	41.1 nTPM
Stomach	86.5 nTPM
Esophagus	55.5 nTPM
Adipose tissue	29.7 nTPM
Spleen	17.3 nTPM
Bone marrow	16.5 nTPM

Respiratory ciliated cells	33.6 nTPM
Bronchus	48.2 nTPM
Lung	19.0 nTPM

Smooth muscle cells	25.7 nTPM
Esophagus	44.9 nTPM
Skin	40.1 nTPM
Bronchus	36.9 nTPM
Adipose tissue	33.4 nTPM
Prostate	32.1 nTPM
Skeletal muscle	25.5 nTPM
Endometrium	19.2 nTPM
Breast	18.9 nTPM
Ovary	16.1 nTPM
Heart muscle	9.0 nTPM
Pancreas	6.6 nTPM

T-cells	19.5 nTPM
Prostate	42.6 nTPM
Lymph node	40.3 nTPM
Adipose tissue	36.2 nTPM
Breast	32.1 nTPM
Spleen	22.4 nTPM
Skeletal muscle	22.1 nTPM
Endometrium	20.2 nTPM
Esophagus	19.7 nTPM
Skin	18.5 nTPM
Colon	17.1 nTPM
Stomach	13.5 nTPM
Liver	12.1 nTPM
Ovary	11.1 nTPM
Bone marrow	7.0 nTPM
Kidney	6.2 nTPM
Lung	6.1 nTPM
PBMC	4.5 nTPM

Basal keratinocytes	48.3 nTPM
Skin	48.3 nTPM

Basal prostatic cells	35.5 nTPM
Prostate	35.5 nTPM

Basal respiratory cells	13.9 nTPM
Bronchus	13.9 nTPM

Cholangiocytes	31.5 nTPM
Liver	31.5 nTPM

Undifferentiated cells	24.3 nTPM
Small intestine	27.5 nTPM
Rectum	24.1 nTPM
Colon	21.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC