Single cell type - FXYD1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FXYD1
Gene descriptionⁱ Full gene name according to HGNC.	FXYD domain containing ion transport regulator 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Hepatocytes - Metabolism (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hepatocytes, Leydig cells, Muller glia cells, Fibroblasts, Smooth muscle cells, Skeletal myocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (memory B-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff, ASC TERT1, HSkMC)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hepatocytes, Leydig cells, Muller glia cells, Fibroblasts, Smooth muscle cells, Skeletal myocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FXYD1 is part of cluster 2 Hepatocytes - Metabolism with confidenceⁱ 1
205 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TBX15	T-box transcription factor 15	0.7472	50
CFH	Complement factor H	0.6354	50
HSPB2	Heat shock protein family B (small) member 2	0.6306	33
C1S	Complement C1s	0.6289	2
C1R	Complement C1r	0.6065	50
ADH1B	Alcohol dehydrogenase 1B (class I), beta polypeptide	0.5998	2
FMO3	Flavin containing dimethylaniline monoxygenase 3	0.5964	2
NNMT	Nicotinamide N-methyltransferase	0.5935	2
RARRES2	Retinoic acid receptor responder 2	0.5895	2
SERPING1	Serpin family G member 1	0.5872	2
BCL6	BCL6 transcription repressor	0.5860	50
TNN	Tenascin N	0.5622	48
F10	Coagulation factor X	0.5609	50
SOD3	Superoxide dismutase 3	0.5568	50
GNMT	Glycine N-methyltransferase	0.5479	2

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	46.1 nTPM
Breast	71.3 nTPM
Adipose tissue	20.9 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	0.0 nTPM
Lung	0.0 nTPM

Astrocytes	44.4 nTPM
Brain	44.4 nTPM

B-cells	15.8 nTPM
Adipose tissue	45.2 nTPM
Bone marrow	26.2 nTPM
Spleen	20.8 nTPM
PBMC	15.7 nTPM
Liver	14.2 nTPM
Breast	13.4 nTPM
Stomach	10.5 nTPM
Lymph node	7.5 nTPM
Kidney	4.8 nTPM
Colon	0.0 nTPM

Dendritic cells	9.5 nTPM
Adipose tissue	13.9 nTPM
Breast	10.6 nTPM
PBMC	4.0 nTPM

Endothelial cells	13.3 nTPM
Breast	58.8 nTPM
Skin	38.7 nTPM
Skeletal muscle	34.9 nTPM
Liver	11.0 nTPM
Prostate	10.3 nTPM
Testis	9.2 nTPM
Esophagus	8.8 nTPM
Eye	6.5 nTPM
Endometrium	5.6 nTPM
Placenta	2.2 nTPM
Ovary	0.4 nTPM
Heart muscle	0.2 nTPM
Lung	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	225.1 nTPM
Breast	523.4 nTPM
Adipose tissue	485.0 nTPM
Esophagus	329.6 nTPM
Skin	281.7 nTPM
Stomach	264.3 nTPM
Skeletal muscle	235.5 nTPM
Placenta	180.8 nTPM
Prostate	157.0 nTPM
Ovary	13.5 nTPM
Lung	5.6 nTPM
Heart muscle	0.0 nTPM

Intestinal goblet cells	0.8 nTPM
Colon	1.4 nTPM
Rectum	1.0 nTPM
Small intestine	0.0 nTPM

Macrophages	5.3 nTPM
Skeletal muscle	12.6 nTPM
Breast	9.3 nTPM
Testis	8.8 nTPM
Adipose tissue	8.7 nTPM
Esophagus	7.9 nTPM
Spleen	7.2 nTPM
Stomach	5.9 nTPM
Ovary	4.7 nTPM
Kidney	4.6 nTPM
Prostate	4.6 nTPM
Endometrium	4.4 nTPM
Bone marrow	1.2 nTPM
Lung	0.0 nTPM
PBMC	0.0 nTPM
Pancreas	0.0 nTPM

Paneth cells	5.3 nTPM
Colon	13.2 nTPM
Rectum	2.7 nTPM
Small intestine	0.0 nTPM

Plasma cells	2.5 nTPM
Adipose tissue	9.7 nTPM
Stomach	2.8 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	12.6 nTPM
Bronchus	19.3 nTPM
Lung	5.8 nTPM

Smooth muscle cells	205.7 nTPM
Breast	489.4 nTPM
Adipose tissue	399.2 nTPM
Skin	358.1 nTPM
Skeletal muscle	316.1 nTPM
Esophagus	307.0 nTPM
Prostate	260.1 nTPM
Endometrium	111.7 nTPM
Bronchus	10.5 nTPM
Ovary	8.7 nTPM
Pancreas	2.0 nTPM
Heart muscle	0.4 nTPM

T-cells	18.8 nTPM
Skin	95.8 nTPM
Adipose tissue	41.9 nTPM
Esophagus	26.2 nTPM
Liver	21.8 nTPM
Breast	20.9 nTPM
Kidney	19.1 nTPM
Skeletal muscle	16.4 nTPM
Spleen	16.3 nTPM
Lymph node	14.6 nTPM
Bone marrow	13.6 nTPM
Endometrium	7.3 nTPM
PBMC	7.1 nTPM
Ovary	6.7 nTPM
Prostate	4.7 nTPM
Stomach	4.0 nTPM
Colon	3.3 nTPM
Lung	0.0 nTPM

Basal keratinocytes	29.4 nTPM
Skin	29.4 nTPM

Basal prostatic cells	3.7 nTPM
Prostate	3.7 nTPM

Basal squamous epithelial cells	8.0 nTPM
Esophagus	8.0 nTPM

Cholangiocytes	11.5 nTPM
Liver	11.5 nTPM

Undifferentiated cells	0.7 nTPM
Colon	1.3 nTPM
Rectum	0.8 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC