Single cell type - SOCS7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SOCS7
Gene descriptionⁱ Full gene name according to HGNC.	Suppressor of cytokine signaling 7
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Not detected in immune cells
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Not detected
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SOCS7 is part of cluster 34 Spermatids - Unknown function with confidenceⁱ 1
366 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PRKAR2A	Protein kinase cAMP-dependent type II regulatory subunit alpha	0.8762	34
TXNDC8	Thioredoxin domain containing 8	0.8746	34
FAM71E1	Family with sequence similarity 71 member E1	0.8732	34
C10orf82	Chromosome 10 open reading frame 82	0.8688	34
HMGB4	High mobility group box 4	0.8672	34
SPATA24	Spermatogenesis associated 24	0.8607	34
IQCF1	IQ motif containing F1	0.8559	34
C8orf74	Chromosome 8 open reading frame 74	0.8544	34
CBY3	Chibby family member 3	0.8503	34
TEX35	Testis expressed 35	0.8483	34
MPP3	Membrane palmitoylated protein 3	0.8469	34
FANCD2OS	FANCD2 opposite strand	0.8413	34
TNP1	Transition protein 1	0.8406	34
FBXO39	F-box protein 39	0.8402	34
MS4A5	Membrane spanning 4-domains A5	0.8400	34

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	4.0 nTPM
Adipose tissue	4.1 nTPM
Breast	4.0 nTPM

Alveolar cells type 1	16.0 nTPM
Lung	16.0 nTPM

Alveolar cells type 2	10.1 nTPM
Lung	10.1 nTPM

Astrocytes	21.2 nTPM
Brain	21.2 nTPM

B-cells	3.5 nTPM
Liver	6.6 nTPM
PBMC	5.7 nTPM
Adipose tissue	5.0 nTPM
Bone marrow	4.9 nTPM
Breast	4.0 nTPM
Lymph node	3.6 nTPM
Spleen	3.1 nTPM
Colon	1.6 nTPM
Stomach	0.5 nTPM
Kidney	0.0 nTPM

Dendritic cells	6.1 nTPM
PBMC	8.0 nTPM
Adipose tissue	8.0 nTPM
Breast	2.2 nTPM

Endothelial cells	5.1 nTPM
Heart muscle	13.3 nTPM
Skeletal muscle	8.4 nTPM
Liver	7.3 nTPM
Placenta	6.8 nTPM
Endometrium	6.3 nTPM
Ovary	5.8 nTPM
Esophagus	5.8 nTPM
Testis	5.7 nTPM
Breast	5.5 nTPM
Prostate	4.2 nTPM
Eye	2.4 nTPM
Skin	0.5 nTPM
Lung	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	6.4 nTPM
Heart muscle	16.0 nTPM
Lung	10.1 nTPM
Skeletal muscle	8.6 nTPM
Ovary	7.7 nTPM
Breast	6.2 nTPM
Placenta	5.0 nTPM
Prostate	4.8 nTPM
Adipose tissue	4.5 nTPM
Esophagus	4.1 nTPM
Stomach	3.0 nTPM
Skin	0.3 nTPM

Intestinal goblet cells	7.0 nTPM
Rectum	8.6 nTPM
Colon	6.5 nTPM
Small intestine	5.8 nTPM

Macrophages	5.0 nTPM
Testis	9.2 nTPM
Bone marrow	8.7 nTPM
Skeletal muscle	8.5 nTPM
Endometrium	8.2 nTPM
Lung	6.4 nTPM
Adipose tissue	6.1 nTPM
Stomach	5.9 nTPM
Breast	5.0 nTPM
Ovary	4.1 nTPM
Esophagus	3.1 nTPM
Spleen	3.1 nTPM
Pancreas	2.5 nTPM
Kidney	2.3 nTPM
Prostate	2.2 nTPM
PBMC	0.0 nTPM

Paneth cells	6.2 nTPM
Rectum	7.7 nTPM
Small intestine	7.5 nTPM
Colon	3.3 nTPM

Plasma cells	2.1 nTPM
Adipose tissue	4.5 nTPM
Spleen	2.3 nTPM
Stomach	2.0 nTPM
Bone marrow	1.7 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	5.3 nTPM
Lung	10.2 nTPM
Bronchus	0.4 nTPM

Smooth muscle cells	6.8 nTPM
Esophagus	17.0 nTPM
Heart muscle	15.2 nTPM
Endometrium	8.9 nTPM
Skeletal muscle	7.5 nTPM
Ovary	7.1 nTPM
Adipose tissue	5.8 nTPM
Prostate	5.0 nTPM
Breast	3.8 nTPM
Pancreas	3.1 nTPM
Skin	1.0 nTPM
Bronchus	0.0 nTPM

T-cells	5.0 nTPM
Skeletal muscle	9.5 nTPM
Adipose tissue	7.9 nTPM
Colon	7.6 nTPM
Lymph node	7.2 nTPM
Esophagus	6.6 nTPM
PBMC	6.5 nTPM
Endometrium	6.2 nTPM
Lung	6.1 nTPM
Breast	5.7 nTPM
Liver	5.6 nTPM
Prostate	4.7 nTPM
Stomach	3.7 nTPM
Spleen	2.6 nTPM
Bone marrow	2.4 nTPM
Ovary	2.2 nTPM
Kidney	0.7 nTPM
Skin	0.0 nTPM

Basal keratinocytes	0.8 nTPM
Skin	0.8 nTPM

Collecting duct cells	1.8 nTPM
Kidney	1.8 nTPM

Cone photoreceptor cells	29.2 nTPM
Eye	29.2 nTPM

Distal tubular cells	1.9 nTPM
Kidney	1.9 nTPM

Undifferentiated cells	6.8 nTPM
Rectum	7.8 nTPM
Small intestine	7.2 nTPM
Colon	5.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC