Immune cell - TRBV13 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRBV13
Gene descriptionⁱ Full gene name according to HGNC.	T cell receptor beta variable 13
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular

IMMUNE CELL SECTION SUMMARY
Immune cell type expression clusterⁱ The RNA data is used to cluster genes according to their expression across immune cells. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	T-cells - T-cell receptor (mainly)
Immune cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (naive CD8 T-cell, T-reg, memory CD8 T-cell, naive CD4 T-cell, memory CD4 T-cell)
Immune cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Immune cell lineage specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: lineage enriched, group enriched, lineage enhanced, low lineage specificity and not detected. Lineages include B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells. Read more	Lineage enriched (T-cells)
Immune cell lineage distributionⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Detected in single

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ

HPA datasetⁱ

Lineage

Expression

Alphabetical

Immune cell type specificity: Group enriched (naive CD8 T-cell, T-reg, memory CD8 T-cell, naive CD4 T-cell, memory CD4 T-cell)

Monaco datasetⁱ

Lineage

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

TRBV13 is part of cluster 20 T-cells - T-cell receptor with confidenceⁱ 1
245 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on immune cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TRBV12-3	T cell receptor beta variable 12-3	0.9586	20
TRAV40	T cell receptor alpha variable 40	0.9524	20
TRAJ26	T cell receptor alpha joining 26	0.9515	20
TRAJ28	T cell receptor alpha joining 28	0.9422	20
TRAJ23	T cell receptor alpha joining 23	0.9373	20
TRAV38-1	T cell receptor alpha variable 38-1	0.9310	20
TRBV12-5	T cell receptor beta variable 12-5	0.8990	20
TRAV39	T cell receptor alpha variable 39	0.8968	20
TRAJ9	T cell receptor alpha joining 9	0.8914	20
TRAV22	T cell receptor alpha variable 22	0.8883	20
TRBV2	T cell receptor beta variable 2	0.8852	20
TRAV13-2	T cell receptor alpha variable 13-2	0.8816	20
TRBV7-6	T cell receptor beta variable 7-6	0.8816	20
TRAV27	T cell receptor alpha variable 27	0.8799	20
TRAJ30	T cell receptor alpha joining 30	0.8763	20