Single cell type - ANKIB1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ANKIB1
Gene descriptionⁱ Full gene name according to HGNC.	Ankyrin repeat and IBR domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

ANKIB1 is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SAMD12	Sterile alpha motif domain containing 12	0.8242	42
EXOC6B	Exocyst complex component 6B	0.8096	42
GRID1	Glutamate ionotropic receptor delta type subunit 1	0.7971	42
UNC5C	Unc-5 netrin receptor C	0.7927	42
NHLH1	Nescient helix-loop-helix 1	0.7927	42
DNAJC6	DnaJ heat shock protein family (Hsp40) member C6	0.7899	42
SIK3	SIK family kinase 3	0.7782	42
AKAP6	A-kinase anchoring protein 6	0.7612	42
DOCK3	Dedicator of cytokinesis 3	0.7592	8
OTUD7A	OTU deubiquitinase 7A	0.7591	42
DIP2C	Disco interacting protein 2 homolog C	0.7571	42
PKP4	Plakophilin 4	0.7571	42
NSMCE2	NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase	0.7531	42
JAKMIP3	Janus kinase and microtubule interacting protein 3	0.7522	42
MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2	0.7509	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	24.1 nTPM
Adipose tissue	25.6 nTPM
Breast	22.6 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	30.4 nTPM
Lung	30.4 nTPM

Astrocytes	97.6 nTPM
Brain	97.6 nTPM

B-cells	21.8 nTPM
Adipose tissue	33.6 nTPM
Colon	25.5 nTPM
Bone marrow	25.3 nTPM
Lymph node	21.2 nTPM
Spleen	20.4 nTPM
Breast	20.0 nTPM
Kidney	19.0 nTPM
PBMC	18.6 nTPM
Liver	18.2 nTPM
Stomach	15.9 nTPM

Dendritic cells	27.8 nTPM
Adipose tissue	37.7 nTPM
PBMC	31.8 nTPM
Breast	13.9 nTPM

Endothelial cells	22.4 nTPM
Heart muscle	32.2 nTPM
Endometrium	30.3 nTPM
Eye	27.5 nTPM
Liver	27.5 nTPM
Ovary	27.4 nTPM
Testis	26.6 nTPM
Skeletal muscle	25.9 nTPM
Breast	23.6 nTPM
Lung	21.8 nTPM
Esophagus	20.0 nTPM
Prostate	14.7 nTPM
Skin	14.7 nTPM
Placenta	13.1 nTPM
Pancreas	7.7 nTPM

Fibroblasts	25.9 nTPM
Skeletal muscle	37.4 nTPM
Adipose tissue	37.1 nTPM
Heart muscle	36.8 nTPM
Breast	30.5 nTPM
Ovary	28.6 nTPM
Skin	24.5 nTPM
Esophagus	22.2 nTPM
Placenta	18.5 nTPM
Lung	17.9 nTPM
Prostate	16.3 nTPM
Stomach	14.9 nTPM

Intestinal goblet cells	24.8 nTPM
Rectum	28.2 nTPM
Small intestine	23.5 nTPM
Colon	22.8 nTPM

Macrophages	20.4 nTPM
Spleen	35.3 nTPM
Skeletal muscle	30.1 nTPM
Adipose tissue	26.2 nTPM
Bone marrow	26.2 nTPM
Ovary	25.4 nTPM
Esophagus	22.0 nTPM
Kidney	21.1 nTPM
Lung	20.5 nTPM
Stomach	20.5 nTPM
Endometrium	18.5 nTPM
Testis	18.0 nTPM
Pancreas	15.3 nTPM
Breast	15.0 nTPM
Prostate	11.5 nTPM
PBMC	0.0 nTPM

Paneth cells	11.8 nTPM
Rectum	21.4 nTPM
Small intestine	7.5 nTPM
Colon	6.5 nTPM

Plasma cells	23.4 nTPM
Adipose tissue	43.2 nTPM
Bone marrow	23.0 nTPM
Stomach	22.7 nTPM
Spleen	21.8 nTPM
Esophagus	6.1 nTPM

Respiratory ciliated cells	18.8 nTPM
Bronchus	21.5 nTPM
Lung	16.0 nTPM

Smooth muscle cells	26.1 nTPM
Adipose tissue	46.4 nTPM
Endometrium	36.4 nTPM
Skeletal muscle	32.6 nTPM
Ovary	26.5 nTPM
Bronchus	24.9 nTPM
Breast	23.4 nTPM
Skin	21.0 nTPM
Esophagus	20.1 nTPM
Heart muscle	19.9 nTPM
Prostate	18.1 nTPM
Pancreas	17.4 nTPM

T-cells	22.7 nTPM
Endometrium	37.2 nTPM
Adipose tissue	33.8 nTPM
Skeletal muscle	29.6 nTPM
PBMC	28.3 nTPM
Lymph node	23.6 nTPM
Bone marrow	22.7 nTPM
Colon	22.3 nTPM
Spleen	22.1 nTPM
Breast	21.5 nTPM
Liver	20.4 nTPM
Ovary	20.1 nTPM
Lung	19.7 nTPM
Skin	19.3 nTPM
Prostate	19.0 nTPM
Kidney	18.5 nTPM
Stomach	15.5 nTPM
Esophagus	13.1 nTPM

Basal prostatic cells	17.5 nTPM
Prostate	17.5 nTPM

Basal respiratory cells	16.4 nTPM
Bronchus	16.4 nTPM

Cholangiocytes	24.3 nTPM
Liver	24.3 nTPM

Collecting duct cells	27.6 nTPM
Kidney	27.6 nTPM

Undifferentiated cells	21.7 nTPM
Rectum	25.6 nTPM
Small intestine	23.9 nTPM
Colon	15.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC