Single cell type - EXOC6B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EXOC6B
Gene descriptionⁱ Full gene name according to HGNC.	Exocyst complex component 6B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Oligodendrocytes - Myelin sheath organization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Microglial cells, Astrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Oligodendrocytes, Inhibitory neurons, Excitatory neurons, Oligodendrocyte precursor cells, Microglial cells, Astrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EXOC6B is part of cluster 42 Oligodendrocytes - Myelin sheath organization with confidenceⁱ 1
385 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DNAJC6	DnaJ heat shock protein family (Hsp40) member C6	0.8756	42
DIP2C	Disco interacting protein 2 homolog C	0.8255	42
PLET1	Placenta expressed transcript 1	0.8204	42
JAKMIP3	Janus kinase and microtubule interacting protein 3	0.8109	42
ANKIB1	Ankyrin repeat and IBR domain containing 1	0.8096	42
OTUD7A	OTU deubiquitinase 7A	0.8064	42
AKAP6	A-kinase anchoring protein 6	0.8048	42
MAGI2	Membrane associated guanylate kinase, WW and PDZ domain containing 2	0.7937	42
TTLL11	Tubulin tyrosine ligase like 11	0.7907	42
RAPGEF6	Rap guanine nucleotide exchange factor 6	0.7845	42
NALCN	Sodium leak channel, non-selective	0.7755	42
SLC24A2	Solute carrier family 24 member 2	0.7752	42
KLHL32	Kelch like family member 32	0.7702	42
FRMD5	FERM domain containing 5	0.7699	42
WDR7	WD repeat domain 7	0.7695	42

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.8 nTPM
Adipose tissue	22.1 nTPM
Breast	13.6 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	4.1 nTPM
Lung	4.1 nTPM

B-cells	4.1 nTPM
Stomach	10.9 nTPM
Lymph node	6.9 nTPM
Spleen	5.5 nTPM
Breast	5.3 nTPM
Adipose tissue	5.0 nTPM
Bone marrow	4.1 nTPM
Liver	1.8 nTPM
PBMC	1.4 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM

Basal keratinocytes	26.1 nTPM
Skin	26.1 nTPM

Dendritic cells	5.0 nTPM
Breast	5.8 nTPM
Adipose tissue	5.1 nTPM
PBMC	4.0 nTPM

Endothelial cells	14.1 nTPM
Heart muscle	33.6 nTPM
Eye	27.5 nTPM
Placenta	16.5 nTPM
Esophagus	14.9 nTPM
Skeletal muscle	14.3 nTPM
Testis	14.2 nTPM
Skin	13.7 nTPM
Prostate	13.2 nTPM
Endometrium	11.7 nTPM
Breast	11.6 nTPM
Ovary	9.4 nTPM
Liver	9.2 nTPM
Pancreas	3.9 nTPM
Lung	3.1 nTPM

Fibroblasts	12.4 nTPM
Heart muscle	37.7 nTPM
Esophagus	17.3 nTPM
Skeletal muscle	14.7 nTPM
Adipose tissue	14.7 nTPM
Skin	11.1 nTPM
Breast	9.2 nTPM
Ovary	9.0 nTPM
Prostate	7.0 nTPM
Stomach	6.0 nTPM
Placenta	5.3 nTPM
Lung	4.5 nTPM

Intestinal goblet cells	6.0 nTPM
Small intestine	12.3 nTPM
Rectum	4.3 nTPM
Colon	1.4 nTPM

Macrophages	5.0 nTPM
Ovary	11.0 nTPM
Adipose tissue	8.6 nTPM
Skeletal muscle	8.3 nTPM
Spleen	8.3 nTPM
Esophagus	7.9 nTPM
Endometrium	6.2 nTPM
Breast	6.0 nTPM
Lung	5.5 nTPM
Testis	4.6 nTPM
Bone marrow	3.7 nTPM
Pancreas	2.5 nTPM
Prostate	1.2 nTPM
Kidney	0.8 nTPM
PBMC	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	8.6 nTPM
Small intestine	11.3 nTPM
Colon	9.9 nTPM
Rectum	4.6 nTPM

Plasma cells	3.7 nTPM
Stomach	10.1 nTPM
Bone marrow	5.0 nTPM
Spleen	2.3 nTPM
Adipose tissue	1.3 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	8.4 nTPM
Lung	8.7 nTPM
Bronchus	8.1 nTPM

Smooth muscle cells	14.7 nTPM
Heart muscle	39.3 nTPM
Ovary	19.2 nTPM
Esophagus	18.6 nTPM
Adipose tissue	16.1 nTPM
Bronchus	13.0 nTPM
Endometrium	11.9 nTPM
Skin	10.4 nTPM
Prostate	10.1 nTPM
Breast	9.6 nTPM
Skeletal muscle	8.9 nTPM
Pancreas	4.5 nTPM

T-cells	4.7 nTPM
Adipose tissue	8.8 nTPM
Skeletal muscle	8.0 nTPM
Spleen	7.3 nTPM
Endometrium	6.8 nTPM
Lymph node	6.6 nTPM
Breast	6.0 nTPM
Stomach	5.2 nTPM
Bone marrow	4.9 nTPM
Prostate	4.7 nTPM
PBMC	3.8 nTPM
Liver	3.6 nTPM
Skin	3.6 nTPM
Colon	3.3 nTPM
Kidney	2.7 nTPM
Ovary	2.2 nTPM
Lung	1.5 nTPM
Esophagus	0.0 nTPM

Astrocytes	210.3 nTPM
Brain	210.3 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Cone photoreceptor cells	25.0 nTPM
Eye	25.0 nTPM

Cytotrophoblasts	15.1 nTPM
Placenta	15.1 nTPM

Undifferentiated cells	4.5 nTPM
Small intestine	7.7 nTPM
Rectum	4.0 nTPM
Colon	1.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC