Single cell type - DVL2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DVL2
Gene descriptionⁱ Full gene name according to HGNC.	Dishevelled segment polarity protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

DVL2 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.99
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TSEN34	TRNA splicing endonuclease subunit 34	0.5327	39
COPS7B	COP9 signalosome subunit 7B	0.4953	20
SAP25	Sin3A associated protein 25	0.4896	20
LRRC42	Leucine rich repeat containing 42	0.4869	52
NOC2L	NOC2 like nucleolar associated transcriptional repressor	0.4753	39
NPM3	Nucleophosmin/nucleoplasmin 3	0.4704	32
RNPS1	RNA binding protein with serine rich domain 1	0.4621	39
PRCC	Proline rich mitotic checkpoint control factor	0.4567	55
RPUSD2	RNA pseudouridine synthase domain containing 2	0.4467	39
FLYWCH2	FLYWCH family member 2	0.4373	13
SERTAD3	SERTA domain containing 3	0.4359	7
PARP16	Poly(ADP-ribose) polymerase family member 16	0.4319	46
CHERP	Calcium homeostasis endoplasmic reticulum protein	0.4303	22
C16orf91	Chromosome 16 open reading frame 91	0.4270	39
ARHGEF19	Rho guanine nucleotide exchange factor 19	0.4239	33

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	11.7 nTPM
Breast	13.4 nTPM
Adipose tissue	10.0 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	12.1 nTPM
Lung	12.1 nTPM

Astrocytes	12.4 nTPM
Brain	12.4 nTPM

B-cells	13.1 nTPM
Lymph node	21.6 nTPM
Breast	20.0 nTPM
Colon	19.2 nTPM
Spleen	16.2 nTPM
Stomach	11.8 nTPM
PBMC	11.5 nTPM
Liver	10.5 nTPM
Adipose tissue	10.0 nTPM
Bone marrow	9.8 nTPM
Kidney	0.0 nTPM

Dendritic cells	11.8 nTPM
Breast	18.2 nTPM
Adipose tissue	9.1 nTPM
PBMC	8.0 nTPM

Endothelial cells	10.5 nTPM
Breast	15.2 nTPM
Endometrium	14.5 nTPM
Ovary	13.3 nTPM
Eye	12.9 nTPM
Liver	12.8 nTPM
Pancreas	11.6 nTPM
Placenta	10.8 nTPM
Skeletal muscle	10.3 nTPM
Skin	10.2 nTPM
Testis	10.1 nTPM
Prostate	9.3 nTPM
Esophagus	8.8 nTPM
Heart muscle	6.5 nTPM
Lung	0.0 nTPM

Fibroblasts	15.7 nTPM
Placenta	24.3 nTPM
Ovary	24.2 nTPM
Breast	19.3 nTPM
Skin	17.6 nTPM
Adipose tissue	16.0 nTPM
Skeletal muscle	15.1 nTPM
Stomach	14.9 nTPM
Lung	13.4 nTPM
Esophagus	13.2 nTPM
Prostate	10.1 nTPM
Heart muscle	4.7 nTPM

Intestinal goblet cells	14.3 nTPM
Rectum	16.9 nTPM
Small intestine	13.9 nTPM
Colon	12.1 nTPM

Macrophages	7.6 nTPM
Ovary	16.7 nTPM
Breast	16.7 nTPM
Esophagus	15.8 nTPM
Pancreas	10.2 nTPM
Prostate	8.1 nTPM
Skeletal muscle	7.6 nTPM
Lung	7.3 nTPM
Endometrium	7.2 nTPM
Adipose tissue	7.1 nTPM
Testis	6.9 nTPM
Kidney	6.8 nTPM
Stomach	2.9 nTPM
Spleen	1.0 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM

Paneth cells	9.9 nTPM
Rectum	15.3 nTPM
Small intestine	11.3 nTPM
Colon	3.3 nTPM

Plasma cells	5.9 nTPM
Bone marrow	8.2 nTPM
Spleen	8.2 nTPM
Stomach	7.9 nTPM
Adipose tissue	5.2 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	9.3 nTPM
Bronchus	12.8 nTPM
Lung	5.8 nTPM

Smooth muscle cells	14.9 nTPM
Skin	27.6 nTPM
Breast	22.4 nTPM
Skeletal muscle	21.2 nTPM
Ovary	19.0 nTPM
Adipose tissue	18.3 nTPM
Endometrium	14.0 nTPM
Pancreas	13.1 nTPM
Prostate	9.4 nTPM
Bronchus	8.5 nTPM
Esophagus	6.2 nTPM
Heart muscle	4.7 nTPM

T-cells	11.5 nTPM
Breast	19.4 nTPM
Colon	18.1 nTPM
Kidney	17.8 nTPM
Lymph node	17.6 nTPM
Spleen	15.3 nTPM
PBMC	13.7 nTPM
Stomach	13.2 nTPM
Bone marrow	11.4 nTPM
Skeletal muscle	11.2 nTPM
Ovary	11.1 nTPM
Endometrium	10.3 nTPM
Skin	9.2 nTPM
Liver	9.0 nTPM
Adipose tissue	8.8 nTPM
Prostate	4.7 nTPM
Lung	4.5 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	17.5 nTPM
Skin	17.5 nTPM

Basal prostatic cells	22.6 nTPM
Prostate	22.6 nTPM

Basal respiratory cells	20.9 nTPM
Bronchus	20.9 nTPM

Cholangiocytes	5.7 nTPM
Liver	5.7 nTPM

Undifferentiated cells	19.6 nTPM
Rectum	23.6 nTPM
Small intestine	23.4 nTPM
Colon	11.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC