Single cell type - PRCC - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PRCC
Gene descriptionⁱ Full gene name according to HGNC.	Proline rich mitotic checkpoint control factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PRCC is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 0.93
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MLF2	Myeloid leukemia factor 2	0.5634	39
TFG	Trafficking from ER to golgi regulator	0.5532	55
RING1	Ring finger protein 1	0.5173	55
CHPF	Chondroitin polymerizing factor	0.5172	55
SCYL1	SCY1 like pseudokinase 1	0.5143	55
C8orf58	Chromosome 8 open reading frame 58	0.5031	18
TMED9	Transmembrane p24 trafficking protein 9	0.4849	55
NKIRAS2	NFKB inhibitor interacting Ras like 2	0.4835	13
LRRC42	Leucine rich repeat containing 42	0.4785	52
ALG2	ALG2 alpha-1,3/1,6-mannosyltransferase	0.4784	55
SLC10A3	Solute carrier family 10 member 3	0.4778	51
B4GALT3	Beta-1,4-galactosyltransferase 3	0.4772	55
SERPINE1	Serpin family E member 1	0.4744	33
KPTN	Kaptin, actin binding protein	0.4741	55
MEST	Mesoderm specific transcript	0.4691	33

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	22.2 nTPM
Breast	25.8 nTPM
Adipose tissue	18.6 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	16.4 nTPM
Lung	16.4 nTPM

Astrocytes	12.7 nTPM
Brain	12.7 nTPM

B-cells	32.0 nTPM
Lymph node	44.1 nTPM
Kidney	42.9 nTPM
Liver	41.0 nTPM
Spleen	34.3 nTPM
Breast	33.4 nTPM
Stomach	30.0 nTPM
PBMC	24.3 nTPM
Colon	23.9 nTPM
Adipose tissue	23.6 nTPM
Bone marrow	22.1 nTPM

Dendritic cells	36.0 nTPM
PBMC	43.8 nTPM
Breast	33.2 nTPM
Adipose tissue	31.0 nTPM

Endothelial cells	30.2 nTPM
Pancreas	77.2 nTPM
Prostate	42.4 nTPM
Placenta	32.4 nTPM
Testis	31.7 nTPM
Liver	30.2 nTPM
Ovary	28.9 nTPM
Skin	28.8 nTPM
Endometrium	26.8 nTPM
Breast	26.2 nTPM
Esophagus	22.3 nTPM
Skeletal muscle	22.2 nTPM
Lung	21.8 nTPM
Eye	18.6 nTPM
Heart muscle	13.1 nTPM

Fibroblasts	28.7 nTPM
Placenta	51.9 nTPM
Prostate	46.0 nTPM
Ovary	36.8 nTPM
Stomach	31.2 nTPM
Skin	27.8 nTPM
Esophagus	26.9 nTPM
Breast	26.2 nTPM
Skeletal muscle	21.4 nTPM
Adipose tissue	21.0 nTPM
Heart muscle	13.5 nTPM
Lung	13.4 nTPM

Intestinal goblet cells	26.9 nTPM
Small intestine	28.5 nTPM
Rectum	26.3 nTPM
Colon	25.7 nTPM

Macrophages	28.4 nTPM
PBMC	40.9 nTPM
Prostate	32.0 nTPM
Esophagus	31.5 nTPM
Kidney	30.3 nTPM
Spleen	30.0 nTPM
Breast	29.9 nTPM
Stomach	29.4 nTPM
Pancreas	28.0 nTPM
Ovary	26.7 nTPM
Skeletal muscle	26.4 nTPM
Adipose tissue	26.4 nTPM
Lung	25.2 nTPM
Testis	25.0 nTPM
Endometrium	22.9 nTPM
Bone marrow	21.2 nTPM

Paneth cells	34.2 nTPM
Small intestine	52.6 nTPM
Rectum	30.2 nTPM
Colon	19.7 nTPM

Plasma cells	48.8 nTPM
Esophagus	61.7 nTPM
Stomach	59.4 nTPM
Spleen	58.8 nTPM
Bone marrow	51.1 nTPM
Adipose tissue	13.0 nTPM

Respiratory ciliated cells	21.5 nTPM
Bronchus	29.8 nTPM
Lung	13.1 nTPM

Smooth muscle cells	29.2 nTPM
Pancreas	48.6 nTPM
Skin	38.4 nTPM
Ovary	37.2 nTPM
Prostate	36.6 nTPM
Skeletal muscle	31.9 nTPM
Bronchus	30.9 nTPM
Esophagus	24.8 nTPM
Adipose tissue	24.7 nTPM
Breast	23.1 nTPM
Endometrium	21.4 nTPM
Heart muscle	3.1 nTPM

T-cells	30.3 nTPM
Breast	42.2 nTPM
Lymph node	39.8 nTPM
Prostate	37.9 nTPM
Spleen	35.6 nTPM
Colon	35.1 nTPM
Esophagus	32.8 nTPM
Kidney	31.5 nTPM
Liver	31.2 nTPM
Stomach	29.2 nTPM
Adipose tissue	27.1 nTPM
PBMC	27.0 nTPM
Endometrium	25.9 nTPM
Skin	25.7 nTPM
Ovary	24.5 nTPM
Bone marrow	24.4 nTPM
Lung	24.3 nTPM
Skeletal muscle	20.9 nTPM

Basal keratinocytes	52.4 nTPM
Skin	52.4 nTPM

Basal prostatic cells	38.2 nTPM
Prostate	38.2 nTPM

Basal respiratory cells	52.1 nTPM
Bronchus	52.1 nTPM

Basal squamous epithelial cells	46.1 nTPM
Esophagus	46.1 nTPM

Undifferentiated cells	29.4 nTPM
Rectum	30.8 nTPM
Small intestine	30.7 nTPM
Colon	26.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC