Single cell type - FBXL3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FBXL3
Gene descriptionⁱ Full gene name according to HGNC.	F-box and leucine rich repeat protein 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Erythroid cells - Oxygen transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

FBXL3 is part of cluster 6 Erythroid cells - Oxygen transport with confidenceⁱ 0.67
151 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CREBRF	CREB3 regulatory factor	0.5312	24
MIER1	MIER1 transcriptional regulator	0.5125	53
GUCD1	Guanylyl cyclase domain containing 1	0.5120	45
SHOC2	SHOC2 leucine rich repeat scaffold protein	0.5078	65
EIF1B	Eukaryotic translation initiation factor 1B	0.4989	39
BCL7B	BAF chromatin remodeling complex subunit BCL7B	0.4778	22
SP2	Sp2 transcription factor	0.4732	59
RMND5A	Required for meiotic nuclear division 5 homolog A	0.4710	6
PNRC1	Proline rich nuclear receptor coactivator 1	0.4613	41
MMGT1	Membrane magnesium transporter 1	0.4536	59
IST1	IST1 factor associated with ESCRT-III	0.4503	53
NR1H2	Nuclear receptor subfamily 1 group H member 2	0.4494	22
MXI1	MAX interactor 1, dimerization protein	0.4463	53
SH3BGRL	SH3 domain binding glutamate rich protein like	0.4459	48
CNST	Consortin, connexin sorting protein	0.4452	44

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	35.9 nTPM
Adipose tissue	38.7 nTPM
Breast	33.2 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	22.2 nTPM
Lung	22.2 nTPM

Astrocytes	31.6 nTPM
Brain	31.6 nTPM

B-cells	48.9 nTPM
Lymph node	90.1 nTPM
Adipose tissue	71.6 nTPM
Colon	63.9 nTPM
Stomach	60.4 nTPM
Spleen	48.2 nTPM
Bone marrow	40.0 nTPM
PBMC	37.1 nTPM
Breast	30.7 nTPM
Kidney	23.8 nTPM
Liver	22.8 nTPM

Dendritic cells	42.4 nTPM
Adipose tissue	62.9 nTPM
Breast	36.4 nTPM
PBMC	27.9 nTPM

Endothelial cells	38.3 nTPM
Skin	60.3 nTPM
Testis	58.1 nTPM
Skeletal muscle	49.6 nTPM
Heart muscle	45.0 nTPM
Liver	43.1 nTPM
Esophagus	42.9 nTPM
Eye	34.8 nTPM
Prostate	34.1 nTPM
Ovary	32.3 nTPM
Breast	32.1 nTPM
Pancreas	30.9 nTPM
Endometrium	30.2 nTPM
Lung	21.8 nTPM
Placenta	21.6 nTPM

Fibroblasts	42.8 nTPM
Adipose tissue	69.1 nTPM
Skin	67.9 nTPM
Skeletal muscle	63.6 nTPM
Esophagus	47.8 nTPM
Breast	43.2 nTPM
Prostate	39.9 nTPM
Heart muscle	38.5 nTPM
Stomach	35.6 nTPM
Placenta	30.3 nTPM
Ovary	19.5 nTPM
Lung	15.7 nTPM

Intestinal goblet cells	23.9 nTPM
Rectum	28.7 nTPM
Colon	26.4 nTPM
Small intestine	16.5 nTPM

Macrophages	33.3 nTPM
PBMC	68.2 nTPM
Adipose tissue	64.6 nTPM
Bone marrow	37.5 nTPM
Prostate	36.7 nTPM
Spleen	36.3 nTPM
Testis	33.7 nTPM
Ovary	33.5 nTPM
Skeletal muscle	33.4 nTPM
Esophagus	28.3 nTPM
Kidney	27.2 nTPM
Lung	25.1 nTPM
Breast	21.2 nTPM
Endometrium	19.1 nTPM
Pancreas	17.8 nTPM
Stomach	17.6 nTPM

Paneth cells	25.7 nTPM
Small intestine	30.0 nTPM
Rectum	27.2 nTPM
Colon	19.7 nTPM

Plasma cells	33.6 nTPM
Adipose tissue	53.5 nTPM
Esophagus	43.0 nTPM
Stomach	30.2 nTPM
Spleen	23.0 nTPM
Bone marrow	18.2 nTPM

Respiratory ciliated cells	19.9 nTPM
Lung	20.4 nTPM
Bronchus	19.3 nTPM

Smooth muscle cells	52.7 nTPM
Skeletal muscle	92.9 nTPM
Adipose tissue	84.2 nTPM
Esophagus	77.6 nTPM
Prostate	68.7 nTPM
Heart muscle	67.4 nTPM
Skin	65.9 nTPM
Breast	38.7 nTPM
Endometrium	32.5 nTPM
Ovary	24.3 nTPM
Pancreas	23.4 nTPM
Bronchus	4.8 nTPM

T-cells	44.9 nTPM
Lymph node	79.3 nTPM
Adipose tissue	78.4 nTPM
Skin	71.3 nTPM
Prostate	61.6 nTPM
Colon	50.8 nTPM
Skeletal muscle	45.5 nTPM
Spleen	43.6 nTPM
Breast	40.7 nTPM
Stomach	40.4 nTPM
PBMC	40.3 nTPM
Kidney	36.9 nTPM
Bone marrow	36.7 nTPM
Esophagus	32.8 nTPM
Endometrium	32.0 nTPM
Ovary	31.1 nTPM
Liver	28.9 nTPM
Lung	12.2 nTPM

Basal keratinocytes	67.3 nTPM
Skin	67.3 nTPM

Basal prostatic cells	38.0 nTPM
Prostate	38.0 nTPM

Basal respiratory cells	17.0 nTPM
Bronchus	17.0 nTPM

Basal squamous epithelial cells	50.1 nTPM
Esophagus	50.1 nTPM

Undifferentiated cells	23.1 nTPM
Rectum	26.3 nTPM
Colon	23.8 nTPM
Small intestine	19.1 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC