Single cell type - SP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SP2
Gene descriptionⁱ Full gene name according to HGNC.	Sp2 transcription factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

SP2 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ARPC4-TTLL3	ARPC4-TTLL3 readthrough	0.5986	59
MAT2B	Methionine adenosyltransferase 2B	0.5894	59
PTPRCAP	Protein tyrosine phosphatase receptor type C associated protein	0.5787	58
RWDD3	RWD domain containing 3	0.5686	59
DAZAP2	DAZ associated protein 2	0.5643	59
ANKHD1	Ankyrin repeat and KH domain containing 1	0.5628	59
NBPF26	NBPF member 26	0.5607	59
UBE2V1	Ubiquitin conjugating enzyme E2 V1	0.5578	59
ADORA2A	Adenosine A2a receptor	0.5577	58
DEFA3	Defensin alpha 3	0.5502	58
ERVK3-1	Endogenous retrovirus group K3 member 1	0.5403	59
HMGN4	High mobility group nucleosomal binding domain 4	0.5355	59
ST20-MTHFS	ST20-MTHFS readthrough	0.5302	59
ZGPAT	Zinc finger CCCH-type and G-patch domain containing	0.5293	59
OVCA2	OVCA2 serine hydrolase domain containing	0.5274	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.6 nTPM
Adipose tissue	17.5 nTPM
Breast	11.7 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	19.5 nTPM
Lung	19.5 nTPM

Astrocytes	5.2 nTPM
Brain	5.2 nTPM

B-cells	17.7 nTPM
Lymph node	28.7 nTPM
Stomach	26.3 nTPM
Bone marrow	24.5 nTPM
Spleen	20.4 nTPM
Colon	19.2 nTPM
Adipose tissue	19.1 nTPM
PBMC	14.3 nTPM
Liver	12.2 nTPM
Kidney	9.5 nTPM
Breast	2.6 nTPM

Dendritic cells	11.3 nTPM
Adipose tissue	16.1 nTPM
Breast	9.9 nTPM
PBMC	8.0 nTPM

Endothelial cells	11.6 nTPM
Esophagus	16.0 nTPM
Prostate	14.8 nTPM
Skeletal muscle	14.2 nTPM
Ovary	14.0 nTPM
Lung	12.5 nTPM
Eye	12.2 nTPM
Skin	11.0 nTPM
Testis	10.9 nTPM
Breast	10.8 nTPM
Placenta	10.2 nTPM
Heart muscle	10.1 nTPM
Liver	9.2 nTPM
Endometrium	8.6 nTPM
Pancreas	7.7 nTPM

Fibroblasts	9.4 nTPM
Adipose tissue	18.3 nTPM
Esophagus	13.5 nTPM
Stomach	13.4 nTPM
Skeletal muscle	11.3 nTPM
Breast	9.3 nTPM
Placenta	8.3 nTPM
Ovary	7.2 nTPM
Skin	6.7 nTPM
Prostate	6.5 nTPM
Heart muscle	4.9 nTPM
Lung	3.4 nTPM

Intestinal goblet cells	9.0 nTPM
Rectum	10.9 nTPM
Colon	9.3 nTPM
Small intestine	6.8 nTPM

Macrophages	14.2 nTPM
Stomach	32.2 nTPM
PBMC	27.3 nTPM
Bone marrow	23.7 nTPM
Kidney	17.5 nTPM
Skeletal muscle	16.7 nTPM
Adipose tissue	14.8 nTPM
Esophagus	11.0 nTPM
Testis	10.5 nTPM
Spleen	10.4 nTPM
Lung	10.2 nTPM
Pancreas	10.2 nTPM
Ovary	9.8 nTPM
Breast	7.0 nTPM
Endometrium	6.5 nTPM
Prostate	5.7 nTPM

Paneth cells	13.2 nTPM
Small intestine	15.0 nTPM
Colon	13.2 nTPM
Rectum	11.6 nTPM

Plasma cells	12.7 nTPM
Stomach	20.9 nTPM
Spleen	18.6 nTPM
Adipose tissue	12.2 nTPM
Bone marrow	11.5 nTPM
Esophagus	0.0 nTPM

Respiratory ciliated cells	10.2 nTPM
Lung	13.1 nTPM
Bronchus	7.4 nTPM

Smooth muscle cells	12.5 nTPM
Heart muscle	28.7 nTPM
Esophagus	17.0 nTPM
Bronchus	16.2 nTPM
Skeletal muscle	16.1 nTPM
Adipose tissue	13.5 nTPM
Pancreas	9.1 nTPM
Breast	7.8 nTPM
Prostate	7.5 nTPM
Skin	7.4 nTPM
Endometrium	7.2 nTPM
Ovary	7.0 nTPM

T-cells	14.8 nTPM
Stomach	24.1 nTPM
Lymph node	23.3 nTPM
Bone marrow	22.5 nTPM
Spleen	19.5 nTPM
Colon	19.0 nTPM
Prostate	19.0 nTPM
Adipose tissue	16.9 nTPM
Liver	14.6 nTPM
Esophagus	13.1 nTPM
PBMC	12.9 nTPM
Lung	12.2 nTPM
Kidney	10.9 nTPM
Breast	10.3 nTPM
Endometrium	10.1 nTPM
Skin	9.2 nTPM
Skeletal muscle	8.0 nTPM
Ovary	6.7 nTPM

Basal keratinocytes	6.2 nTPM
Skin	6.2 nTPM

Basal prostatic cells	15.8 nTPM
Prostate	15.8 nTPM

Basal squamous epithelial cells	12.0 nTPM
Esophagus	12.0 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Undifferentiated cells	7.9 nTPM
Rectum	9.5 nTPM
Small intestine	8.0 nTPM
Colon	6.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC