Single cell type - PDK2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PDK2
Gene descriptionⁱ Full gene name according to HGNC.	Pyruvate dehydrogenase kinase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Proximal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Proximal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PDK2 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
DHRS4L2	Dehydrogenase/reductase 4 like 2	0.7139	67
PEPD	Peptidase D	0.7116	67
CRYL1	Crystallin lambda 1	0.7096	67
DHDH	Dihydrodiol dehydrogenase	0.7056	67
EPHX2	Epoxide hydrolase 2	0.7029	67
AKR7A3	Aldo-keto reductase family 7 member A3	0.7020	67
GPD1	Glycerol-3-phosphate dehydrogenase 1	0.6997	67
ERICH4	Glutamate rich 4	0.6977	67
PCK1	Phosphoenolpyruvate carboxykinase 1	0.6916	67
CMBL	Carboxymethylenebutenolidase homolog	0.6913	67
SAT2	Spermidine/spermine N1-acetyltransferase family member 2	0.6868	67
ACY3	Aminoacylase 3	0.6846	67
KHK	Ketohexokinase	0.6792	67
SLC28A1	Solute carrier family 28 member 1	0.6561	67
AKR7A2	Aldo-keto reductase family 7 member A2	0.6540	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	17.9 nTPM
Breast	21.5 nTPM
Adipose tissue	14.2 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	10.3 nTPM
Lung	10.3 nTPM

Astrocytes	18.3 nTPM
Brain	18.3 nTPM

B-cells	12.1 nTPM
Liver	29.4 nTPM
Bone marrow	14.7 nTPM
Breast	14.7 nTPM
PBMC	14.3 nTPM
Spleen	10.7 nTPM
Lymph node	10.4 nTPM
Kidney	9.5 nTPM
Stomach	9.1 nTPM
Adipose tissue	5.0 nTPM
Colon	3.2 nTPM

Dendritic cells	16.7 nTPM
PBMC	27.9 nTPM
Breast	12.0 nTPM
Adipose tissue	10.1 nTPM

Endothelial cells	11.8 nTPM
Ovary	21.8 nTPM
Breast	21.8 nTPM
Placenta	17.6 nTPM
Liver	16.5 nTPM
Esophagus	16.0 nTPM
Testis	14.5 nTPM
Skin	13.9 nTPM
Endometrium	10.9 nTPM
Skeletal muscle	10.4 nTPM
Eye	8.9 nTPM
Lung	6.2 nTPM
Prostate	5.4 nTPM
Heart muscle	1.3 nTPM
Pancreas	0.0 nTPM

Fibroblasts	17.7 nTPM
Breast	28.7 nTPM
Ovary	27.3 nTPM
Placenta	26.7 nTPM
Esophagus	26.1 nTPM
Skin	24.9 nTPM
Adipose tissue	19.1 nTPM
Stomach	17.8 nTPM
Skeletal muscle	11.9 nTPM
Prostate	8.2 nTPM
Heart muscle	2.4 nTPM
Lung	1.2 nTPM

Intestinal goblet cells	50.2 nTPM
Rectum	54.9 nTPM
Small intestine	52.2 nTPM
Colon	43.6 nTPM

Macrophages	12.0 nTPM
PBMC	40.9 nTPM
Ovary	18.6 nTPM
Pancreas	17.8 nTPM
Kidney	16.6 nTPM
Breast	11.9 nTPM
Bone marrow	10.0 nTPM
Esophagus	9.4 nTPM
Prostate	9.1 nTPM
Endometrium	8.9 nTPM
Testis	8.1 nTPM
Adipose tissue	7.1 nTPM
Skeletal muscle	6.9 nTPM
Spleen	6.2 nTPM
Lung	4.7 nTPM
Stomach	2.9 nTPM

Paneth cells	55.2 nTPM
Small intestine	71.4 nTPM
Rectum	48.2 nTPM
Colon	46.1 nTPM

Plasma cells	25.9 nTPM
Spleen	34.7 nTPM
Bone marrow	31.3 nTPM
Stomach	28.6 nTPM
Esophagus	24.6 nTPM
Adipose tissue	10.3 nTPM

Respiratory ciliated cells	6.5 nTPM
Bronchus	11.6 nTPM
Lung	1.5 nTPM

Smooth muscle cells	20.5 nTPM
Breast	45.0 nTPM
Esophagus	35.7 nTPM
Skin	28.3 nTPM
Ovary	22.3 nTPM
Adipose tissue	21.7 nTPM
Prostate	21.6 nTPM
Endometrium	18.0 nTPM
Skeletal muscle	15.2 nTPM
Pancreas	14.1 nTPM
Bronchus	2.8 nTPM
Heart muscle	1.2 nTPM

T-cells	12.9 nTPM
Ovary	24.5 nTPM
Kidney	20.5 nTPM
Prostate	19.0 nTPM
Skin	17.5 nTPM
PBMC	17.4 nTPM
Liver	15.3 nTPM
Bone marrow	12.1 nTPM
Breast	12.1 nTPM
Lymph node	11.8 nTPM
Stomach	11.8 nTPM
Colon	10.9 nTPM
Skeletal muscle	9.5 nTPM
Spleen	9.4 nTPM
Lung	7.6 nTPM
Adipose tissue	7.2 nTPM
Esophagus	6.6 nTPM
Endometrium	6.0 nTPM

Basal prostatic cells	12.3 nTPM
Prostate	12.3 nTPM

Basal respiratory cells	12.4 nTPM
Bronchus	12.4 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Collecting duct cells	20.2 nTPM
Kidney	20.2 nTPM

Undifferentiated cells	36.9 nTPM
Small intestine	52.3 nTPM
Rectum	39.6 nTPM
Colon	19.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC