Single cell type - EPHX2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EPHX2
Gene descriptionⁱ Full gene name according to HGNC.	Epoxide hydrolase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Proximal tubular cells - Tubular reabsorption (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes, Proximal tubular cells, Distal tubular cells, Hepatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (naive CD4 T-cell, naive CD8 T-cell, memory CD4 T-cell, T-reg)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (JURKAT, K-562, OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes, Proximal tubular cells, Distal tubular cells, Hepatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EPHX2 is part of cluster 67 Proximal tubular cells - Tubular reabsorption with confidenceⁱ 1
499 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NAPRT	Nicotinate phosphoribosyltransferase	0.8286	67
AKR7A3	Aldo-keto reductase family 7 member A3	0.7773	67
ERICH4	Glutamate rich 4	0.7503	67
DHDH	Dihydrodiol dehydrogenase	0.7440	67
LGALS2	Galectin 2	0.7425	67
CMBL	Carboxymethylenebutenolidase homolog	0.7424	67
PPP1R16A	Protein phosphatase 1 regulatory subunit 16A	0.7264	67
TKFC	Triokinase and FMN cyclase	0.7255	45
ALDOB	Aldolase, fructose-bisphosphate B	0.7169	67
KHK	Ketohexokinase	0.7160	67
SAT2	Spermidine/spermine N1-acetyltransferase family member 2	0.7132	67
ACY1	Aminoacylase 1	0.7131	67
SLC13A2	Solute carrier family 13 member 2	0.7082	67
PDK2	Pyruvate dehydrogenase kinase 2	0.7029	67
SLC39A4	Solute carrier family 39 member 4	0.6892	67

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	6.3 nTPM
Breast	8.4 nTPM
Adipose tissue	4.1 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	17.0 nTPM
Lung	17.0 nTPM

Astrocytes	16.3 nTPM
Brain	16.3 nTPM

B-cells	6.1 nTPM
Kidney	23.8 nTPM
Liver	8.5 nTPM
PBMC	7.1 nTPM
Colon	4.8 nTPM
Stomach	4.5 nTPM
Breast	4.0 nTPM
Spleen	2.8 nTPM
Lymph node	2.5 nTPM
Bone marrow	2.5 nTPM
Adipose tissue	0.5 nTPM

Dendritic cells	1.0 nTPM
Breast	2.2 nTPM
Adipose tissue	0.8 nTPM
PBMC	0.0 nTPM

Endothelial cells	9.4 nTPM
Liver	25.7 nTPM
Testis	16.9 nTPM
Breast	13.6 nTPM
Lung	12.5 nTPM
Esophagus	11.3 nTPM
Skeletal muscle	8.5 nTPM
Placenta	8.0 nTPM
Skin	6.8 nTPM
Eye	6.5 nTPM
Ovary	6.3 nTPM
Heart muscle	5.8 nTPM
Prostate	5.3 nTPM
Endometrium	4.5 nTPM
Pancreas	0.0 nTPM

Fibroblasts	12.1 nTPM
Esophagus	27.4 nTPM
Breast	19.1 nTPM
Ovary	15.8 nTPM
Heart muscle	13.8 nTPM
Placenta	13.3 nTPM
Skeletal muscle	9.9 nTPM
Lung	7.8 nTPM
Adipose tissue	7.7 nTPM
Stomach	7.4 nTPM
Prostate	6.5 nTPM
Skin	4.9 nTPM

Intestinal goblet cells	63.4 nTPM
Small intestine	108.3 nTPM
Rectum	56.2 nTPM
Colon	25.7 nTPM

Macrophages	3.6 nTPM
PBMC	27.3 nTPM
Kidney	15.8 nTPM
Breast	2.9 nTPM
Skeletal muscle	2.1 nTPM
Lung	1.8 nTPM
Esophagus	1.6 nTPM
Prostate	1.2 nTPM
Endometrium	1.0 nTPM
Testis	0.6 nTPM
Adipose tissue	0.3 nTPM
Ovary	0.1 nTPM
Pancreas	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	83.7 nTPM
Small intestine	138.9 nTPM
Rectum	82.5 nTPM
Colon	29.6 nTPM

Plasma cells	4.5 nTPM
Esophagus	12.3 nTPM
Stomach	5.4 nTPM
Adipose tissue	2.7 nTPM
Spleen	2.3 nTPM
Bone marrow	0.0 nTPM

Respiratory ciliated cells	24.1 nTPM
Lung	26.2 nTPM
Bronchus	22.0 nTPM

Smooth muscle cells	10.2 nTPM
Esophagus	21.7 nTPM
Skin	13.9 nTPM
Prostate	13.4 nTPM
Breast	12.7 nTPM
Skeletal muscle	11.4 nTPM
Adipose tissue	10.6 nTPM
Heart muscle	9.5 nTPM
Bronchus	7.5 nTPM
Pancreas	5.1 nTPM
Ovary	3.5 nTPM
Endometrium	3.1 nTPM

T-cells	11.9 nTPM
PBMC	62.2 nTPM
Lymph node	27.5 nTPM
Kidney	22.6 nTPM
Lung	15.2 nTPM
Bone marrow	11.1 nTPM
Spleen	10.6 nTPM
Liver	9.2 nTPM
Breast	9.0 nTPM
Ovary	6.7 nTPM
Stomach	6.7 nTPM
Colon	6.2 nTPM
Skeletal muscle	4.9 nTPM
Skin	4.6 nTPM
Adipose tissue	4.1 nTPM
Endometrium	2.2 nTPM
Prostate	0.0 nTPM
Esophagus	0.0 nTPM

Basal prostatic cells	18.6 nTPM
Prostate	18.6 nTPM

Basal respiratory cells	10.1 nTPM
Bronchus	10.1 nTPM

Cholangiocytes	20.0 nTPM
Liver	20.0 nTPM

Collecting duct cells	27.6 nTPM
Kidney	27.6 nTPM

Undifferentiated cells	101.3 nTPM
Small intestine	160.5 nTPM
Rectum	93.9 nTPM
Colon	49.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC