Single cell type - TMEM98 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMEM98
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane protein 98
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (plasmacytoid DC)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CACO-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMEM98 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
P3H4	Prolyl 3-hydroxylase family member 4 (inactive)	0.6638	33
EPCAM	Epithelial cell adhesion molecule	0.6433	53
CYP2W1	Cytochrome P450 family 2 subfamily W member 1	0.6089	33
LGALS4	Galectin 4	0.5855	53
MDK	Midkine	0.5851	33
GATA6	GATA binding protein 6	0.5788	53
CDX2	Caudal type homeobox 2	0.5718	53
DEFA6	Defensin alpha 6	0.5624	53
ABO	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	0.5596	45
GIP	Gastric inhibitory polypeptide	0.5565	33
HSD3B2	Hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	0.5560	52
KDELR3	KDEL endoplasmic reticulum protein retention receptor 3	0.5550	33
FKBP10	FKBP prolyl isomerase 10	0.5465	33
B3GALT5	Beta-1,3-galactosyltransferase 5	0.5465	53
DEFA5	Defensin alpha 5	0.5444	45

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	7.6 nTPM
Breast	11.4 nTPM
Adipose tissue	3.9 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	24.8 nTPM
Lung	24.8 nTPM

Astrocytes	6.2 nTPM
Brain	6.2 nTPM

B-cells	0.6 nTPM
Breast	4.0 nTPM
Colon	1.6 nTPM
Liver	0.4 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Dendritic cells	0.7 nTPM
Breast	2.2 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM

Endothelial cells	7.8 nTPM
Skin	19.4 nTPM
Breast	15.7 nTPM
Lung	15.6 nTPM
Placenta	14.2 nTPM
Esophagus	8.0 nTPM
Prostate	6.6 nTPM
Eye	5.7 nTPM
Skeletal muscle	4.8 nTPM
Endometrium	4.6 nTPM
Heart muscle	4.1 nTPM
Pancreas	3.9 nTPM
Ovary	2.9 nTPM
Testis	2.1 nTPM
Liver	1.8 nTPM

Enteroendocrine cells	97.9 nTPM
Rectum	114.1 nTPM
Colon	81.7 nTPM

Fibroblasts	127.2 nTPM
Placenta	315.5 nTPM
Ovary	203.8 nTPM
Breast	182.3 nTPM
Lung	131.8 nTPM
Adipose tissue	116.7 nTPM
Skin	109.9 nTPM
Esophagus	100.8 nTPM
Prostate	72.4 nTPM
Skeletal muscle	68.7 nTPM
Stomach	66.9 nTPM
Heart muscle	30.4 nTPM

Intestinal goblet cells	145.7 nTPM
Rectum	174.7 nTPM
Small intestine	159.3 nTPM
Colon	102.9 nTPM

Macrophages	2.0 nTPM
Lung	4.7 nTPM
Prostate	3.4 nTPM
Endometrium	3.4 nTPM
Ovary	3.4 nTPM
Stomach	2.9 nTPM
Skeletal muscle	2.8 nTPM
Pancreas	2.5 nTPM
Kidney	2.3 nTPM
Breast	2.2 nTPM
Esophagus	1.6 nTPM
Testis	0.6 nTPM
Adipose tissue	0.1 nTPM
PBMC	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Paneth cells	97.9 nTPM
Rectum	160.6 nTPM
Small intestine	90.1 nTPM
Colon	42.8 nTPM

Plasma cells	0.2 nTPM
Adipose tissue	0.6 nTPM
Stomach	0.5 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	54.6 nTPM
Bronchus	65.5 nTPM
Lung	43.7 nTPM

Smooth muscle cells	55.5 nTPM
Ovary	189.1 nTPM
Pancreas	106.5 nTPM
Endometrium	46.2 nTPM
Breast	45.7 nTPM
Adipose tissue	45.2 nTPM
Skin	40.4 nTPM
Prostate	31.9 nTPM
Esophagus	31.0 nTPM
Bronchus	28.9 nTPM
Skeletal muscle	24.6 nTPM
Heart muscle	20.5 nTPM

Basal keratinocytes	25.1 nTPM
Skin	25.1 nTPM

Basal prostatic cells	76.1 nTPM
Prostate	76.1 nTPM

Basal respiratory cells	111.5 nTPM
Bronchus	111.5 nTPM

Cholangiocytes	72.9 nTPM
Liver	72.9 nTPM

T-cells	2.4 nTPM
Skin	10.5 nTPM
Endometrium	7.9 nTPM
Lung	6.1 nTPM
Kidney	4.7 nTPM
Prostate	4.7 nTPM
Colon	3.8 nTPM
Breast	2.0 nTPM
Skeletal muscle	1.3 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Ovary	0.0 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Undifferentiated cells	166.6 nTPM
Rectum	209.7 nTPM
Small intestine	166.4 nTPM
Colon	123.7 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC