Single cell type - GATA6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GATA6
Gene descriptionⁱ Full gene name according to HGNC.	GATA binding protein 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Gastric mucus-secreting cells, Cardiomyocytes, Granulosa cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (basophil)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BEWO, CACO-2, hTERT-RPE1, OE19)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Gastric mucus-secreting cells, Cardiomyocytes, Granulosa cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GATA6 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TMEM98	Transmembrane protein 98	0.5788	53
HSDL2	Hydroxysteroid dehydrogenase like 2	0.5673	40
PPP1R26	Protein phosphatase 1 regulatory subunit 26	0.5660	40
HAND1	Heart and neural crest derivatives expressed 1	0.5640	54
FOXP4	Forkhead box P4	0.5605	27
LGALS4	Galectin 4	0.5304	53
MYZAP	Myocardial zonula adherens protein	0.5237	54
CASP6	Caspase 6	0.5221	40
ZNF358	Zinc finger protein 358	0.5194	40
GPRIN2	G protein regulated inducer of neurite outgrowth 2	0.5113	27
CCNJL	Cyclin J like	0.5112	27
DNAJC22	DnaJ heat shock protein family (Hsp40) member C22	0.5112	53
CCND2	Cyclin D2	0.5095	40
IHH	Indian hedgehog signaling molecule	0.5092	40
NUTM2A	NUT family member 2A	0.5086	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	7.3 nTPM
Adipose tissue	11.1 nTPM
Breast	3.6 nTPM

Alveolar cells type 1	44.8 nTPM
Lung	44.8 nTPM

Alveolar cells type 2	30.2 nTPM
Lung	30.2 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

B-cells	0.0 nTPM
Stomach	0.5 nTPM
Colon	0.0 nTPM
Kidney	0.0 nTPM
Liver	0.0 nTPM
PBMC	0.0 nTPM
Adipose tissue	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Breast	0.0 nTPM

Dendritic cells	0.9 nTPM
Breast	1.8 nTPM
Adipose tissue	1.0 nTPM
PBMC	0.0 nTPM

Endothelial cells	11.5 nTPM
Liver	39.4 nTPM
Heart muscle	23.7 nTPM
Endometrium	23.7 nTPM
Lung	21.8 nTPM
Skeletal muscle	9.9 nTPM
Placenta	9.1 nTPM
Esophagus	8.3 nTPM
Testis	6.8 nTPM
Skin	5.1 nTPM
Ovary	5.0 nTPM
Breast	4.8 nTPM
Prostate	4.0 nTPM
Eye	0.0 nTPM
Pancreas	0.0 nTPM

Fibroblasts	24.4 nTPM
Placenta	79.6 nTPM
Heart muscle	68.3 nTPM
Lung	35.7 nTPM
Ovary	30.8 nTPM
Prostate	15.6 nTPM
Adipose tissue	10.4 nTPM
Stomach	10.4 nTPM
Esophagus	5.9 nTPM
Breast	5.0 nTPM
Skeletal muscle	4.2 nTPM
Skin	2.3 nTPM

Intestinal goblet cells	45.8 nTPM
Rectum	61.6 nTPM
Small intestine	48.7 nTPM
Colon	27.1 nTPM

Macrophages	0.5 nTPM
Ovary	2.2 nTPM
Endometrium	2.0 nTPM
Prostate	1.2 nTPM
Lung	1.1 nTPM
Adipose tissue	0.7 nTPM
Skeletal muscle	0.4 nTPM
Breast	0.3 nTPM
Kidney	0.0 nTPM
PBMC	0.0 nTPM
Testis	0.0 nTPM
Pancreas	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM
Stomach	0.0 nTPM

Paneth cells	27.7 nTPM
Rectum	51.0 nTPM
Small intestine	18.8 nTPM
Colon	13.2 nTPM

Plasma cells	0.2 nTPM
Stomach	0.9 nTPM
Adipose tissue	0.0 nTPM
Esophagus	0.0 nTPM
Bone marrow	0.0 nTPM
Spleen	0.0 nTPM

Respiratory ciliated cells	3.9 nTPM
Bronchus	4.8 nTPM
Lung	2.9 nTPM

Smooth muscle cells	8.6 nTPM
Ovary	31.5 nTPM
Skeletal muscle	18.8 nTPM
Prostate	12.5 nTPM
Heart muscle	7.6 nTPM
Endometrium	6.6 nTPM
Pancreas	6.4 nTPM
Adipose tissue	5.8 nTPM
Breast	3.6 nTPM
Bronchus	0.9 nTPM
Skin	0.4 nTPM
Esophagus	0.0 nTPM

T-cells	1.3 nTPM
Colon	3.3 nTPM
Lung	3.0 nTPM
Adipose tissue	2.6 nTPM
Endometrium	2.3 nTPM
Ovary	2.2 nTPM
Skeletal muscle	2.0 nTPM
Stomach	1.8 nTPM
PBMC	1.0 nTPM
Skin	0.9 nTPM
Breast	0.8 nTPM
Kidney	0.7 nTPM
Spleen	0.7 nTPM
Liver	0.6 nTPM
Prostate	0.0 nTPM
Esophagus	0.0 nTPM
Lymph node	0.0 nTPM
Bone marrow	0.0 nTPM

Basal respiratory cells	4.6 nTPM
Bronchus	4.6 nTPM

Cholangiocytes	30.0 nTPM
Liver	30.0 nTPM

Distal enterocytes	50.0 nTPM
Rectum	72.9 nTPM
Colon	27.0 nTPM

Early spermatids	44.7 nTPM
Testis	44.7 nTPM

Undifferentiated cells	47.2 nTPM
Small intestine	59.2 nTPM
Rectum	54.1 nTPM
Colon	28.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC