Single cell type - PGM3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PGM3
Gene descriptionⁱ Full gene name according to HGNC.	Phosphoglucomutase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PGM3 is part of cluster 55 Plasma cells - Humoral immune response with confidenceⁱ 0.93
379 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KDELR2	KDEL endoplasmic reticulum protein retention receptor 2	0.7423	55
YIPF2	Yip1 domain family member 2	0.6755	66
FAM114A1	Family with sequence similarity 114 member A1	0.5800	33
KDELR3	KDEL endoplasmic reticulum protein retention receptor 3	0.5772	33
MMADHC	Metabolism of cobalamin associated D	0.5504	26
RAB2A	RAB2A, member RAS oncogene family	0.5312	55
SEC13	SEC13 homolog, nuclear pore and COPII coat complex component	0.5263	55
TFG	Trafficking from ER to golgi regulator	0.5230	55
FBXO8	F-box protein 8	0.5132	33
GLT8D1	Glycosyltransferase 8 domain containing 1	0.5122	66
PELO	Pelota mRNA surveillance and ribosome rescue factor	0.5110	33
SLC39A7	Solute carrier family 39 member 7	0.5096	27
CKAP4	Cytoskeleton associated protein 4	0.5030	55
PYCR1	Pyrroline-5-carboxylate reductase 1	0.5003	30
IGFBP3	Insulin like growth factor binding protein 3	0.4952	33

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	14.3 nTPM
Adipose tissue	14.3 nTPM
Breast	14.3 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	27.7 nTPM
Lung	27.7 nTPM

Astrocytes	14.4 nTPM
Brain	14.4 nTPM

B-cells	13.0 nTPM
Liver	36.7 nTPM
Breast	25.5 nTPM
Lymph node	13.1 nTPM
Adipose tissue	13.0 nTPM
PBMC	9.9 nTPM
Bone marrow	9.0 nTPM
Stomach	7.7 nTPM
Spleen	7.6 nTPM
Kidney	4.8 nTPM
Colon	3.2 nTPM

Dendritic cells	12.7 nTPM
PBMC	16.0 nTPM
Adipose tissue	11.3 nTPM
Breast	11.0 nTPM

Endothelial cells	13.8 nTPM
Prostate	26.8 nTPM
Ovary	23.3 nTPM
Endometrium	20.5 nTPM
Placenta	14.8 nTPM
Esophagus	14.0 nTPM
Skeletal muscle	13.7 nTPM
Heart muscle	13.4 nTPM
Testis	12.2 nTPM
Pancreas	11.6 nTPM
Breast	10.4 nTPM
Liver	10.1 nTPM
Skin	9.1 nTPM
Eye	7.3 nTPM
Lung	6.2 nTPM

Fibroblasts	46.1 nTPM
Placenta	101.8 nTPM
Prostate	97.1 nTPM
Lung	49.2 nTPM
Stomach	47.5 nTPM
Skeletal muscle	42.9 nTPM
Ovary	39.0 nTPM
Adipose tissue	31.3 nTPM
Heart muscle	29.6 nTPM
Skin	27.6 nTPM
Breast	22.9 nTPM
Esophagus	17.9 nTPM

Intestinal goblet cells	35.5 nTPM
Colon	58.6 nTPM
Small intestine	27.0 nTPM
Rectum	21.0 nTPM

Macrophages	8.6 nTPM
Lung	14.4 nTPM
Endometrium	14.0 nTPM
Testis	12.8 nTPM
Breast	10.3 nTPM
Ovary	10.0 nTPM
Skeletal muscle	9.9 nTPM
Esophagus	9.4 nTPM
Kidney	9.1 nTPM
Prostate	9.1 nTPM
Spleen	8.3 nTPM
Pancreas	7.7 nTPM
Adipose tissue	7.7 nTPM
Bone marrow	3.7 nTPM
Stomach	2.9 nTPM
PBMC	0.0 nTPM

Paneth cells	19.7 nTPM
Rectum	20.5 nTPM
Colon	19.7 nTPM
Small intestine	18.8 nTPM

Plasma cells	44.1 nTPM
Stomach	74.4 nTPM
Spleen	62.1 nTPM
Bone marrow	37.9 nTPM
Adipose tissue	27.7 nTPM
Esophagus	18.4 nTPM

Respiratory ciliated cells	22.2 nTPM
Bronchus	31.2 nTPM
Lung	13.1 nTPM

Smooth muscle cells	26.6 nTPM
Pancreas	118.6 nTPM
Prostate	40.9 nTPM
Endometrium	28.0 nTPM
Ovary	24.3 nTPM
Bronchus	18.9 nTPM
Adipose tissue	14.7 nTPM
Skeletal muscle	12.1 nTPM
Skin	11.5 nTPM
Breast	9.6 nTPM
Esophagus	7.8 nTPM
Heart muscle	6.5 nTPM

T-cells	10.1 nTPM
Prostate	33.1 nTPM
Endometrium	14.3 nTPM
Breast	14.1 nTPM
Lung	13.6 nTPM
PBMC	12.0 nTPM
Lymph node	11.6 nTPM
Kidney	10.9 nTPM
Adipose tissue	10.8 nTPM
Skeletal muscle	9.5 nTPM
Spleen	8.4 nTPM
Bone marrow	8.1 nTPM
Liver	6.8 nTPM
Stomach	5.8 nTPM
Skin	4.6 nTPM
Ovary	4.5 nTPM
Colon	4.3 nTPM
Esophagus	0.0 nTPM

Basal keratinocytes	15.8 nTPM
Skin	15.8 nTPM

Basal prostatic cells	29.2 nTPM
Prostate	29.2 nTPM

Basal respiratory cells	28.5 nTPM
Bronchus	28.5 nTPM

Basal squamous epithelial cells	5.7 nTPM
Esophagus	5.7 nTPM

Undifferentiated cells	17.6 nTPM
Colon	18.0 nTPM
Rectum	17.5 nTPM
Small intestine	17.2 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC