Single cell type - GLT8D1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GLT8D1
Gene descriptionⁱ Full gene name according to HGNC.	Glycosyltransferase 8 domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Spermatocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

GLT8D1 is part of cluster 66 Spermatocytes - Spermatogenesis with confidenceⁱ 0.98
507 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BAG2	BAG cochaperone 2	0.5646	33
TP53I13	Tumor protein p53 inducible protein 13	0.5436	33
SNUPN	Snurportin 1	0.5331	66
GLB1L	Galactosidase beta 1 like	0.5253	66
PGM3	Phosphoglucomutase 3	0.5122	55
GALNS	Galactosamine (N-acetyl)-6-sulfatase	0.5003	20
YIPF2	Yip1 domain family member 2	0.4941	66
GTPBP8	GTP binding protein 8 (putative)	0.4936	66
ZCCHC9	Zinc finger CCHC-type containing 9	0.4935	66
YIPF5	Yip1 domain family member 5	0.4877	55
ATRAID	All-trans retinoic acid induced differentiation factor	0.4820	26
IAH1	Isoamyl acetate hydrolyzing esterase 1 (putative)	0.4804	66
PRDM6	PR/SET domain 6	0.4798	33
FIBIN	Fin bud initiation factor homolog	0.4797	33
CILP2	Cartilage intermediate layer protein 2	0.4794	66

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	25.8 nTPM
Breast	27.5 nTPM
Adipose tissue	24.1 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	9.6 nTPM
Lung	9.6 nTPM

Astrocytes	16.0 nTPM
Brain	16.0 nTPM

B-cells	16.0 nTPM
Breast	40.2 nTPM
Liver	34.0 nTPM
Bone marrow	13.1 nTPM
PBMC	12.9 nTPM
Spleen	12.8 nTPM
Lymph node	12.3 nTPM
Adipose tissue	10.5 nTPM
Kidney	9.5 nTPM
Stomach	8.1 nTPM
Colon	6.4 nTPM

Dendritic cells	26.5 nTPM
Breast	31.7 nTPM
PBMC	27.9 nTPM
Adipose tissue	19.8 nTPM

Endothelial cells	22.7 nTPM
Placenta	39.3 nTPM
Pancreas	34.7 nTPM
Ovary	32.0 nTPM
Heart muscle	23.6 nTPM
Eye	23.5 nTPM
Breast	23.5 nTPM
Esophagus	23.1 nTPM
Testis	21.4 nTPM
Endometrium	21.3 nTPM
Liver	20.2 nTPM
Skeletal muscle	20.0 nTPM
Skin	17.9 nTPM
Prostate	14.8 nTPM
Lung	3.1 nTPM

Fibroblasts	59.2 nTPM
Placenta	112.2 nTPM
Adipose tissue	95.7 nTPM
Breast	72.4 nTPM
Skeletal muscle	69.0 nTPM
Ovary	59.5 nTPM
Stomach	55.0 nTPM
Heart muscle	54.6 nTPM
Esophagus	52.6 nTPM
Skin	50.2 nTPM
Prostate	22.0 nTPM
Lung	7.8 nTPM

Intestinal goblet cells	21.1 nTPM
Rectum	24.6 nTPM
Colon	20.1 nTPM
Small intestine	18.5 nTPM

Macrophages	12.3 nTPM
Ovary	23.2 nTPM
Breast	19.2 nTPM
Esophagus	15.8 nTPM
PBMC	13.6 nTPM
Spleen	13.5 nTPM
Testis	12.8 nTPM
Pancreas	12.8 nTPM
Skeletal muscle	12.2 nTPM
Kidney	12.0 nTPM
Endometrium	10.6 nTPM
Adipose tissue	9.3 nTPM
Stomach	8.8 nTPM
Bone marrow	8.7 nTPM
Lung	8.2 nTPM
Prostate	3.4 nTPM

Paneth cells	16.9 nTPM
Small intestine	26.3 nTPM
Rectum	21.1 nTPM
Colon	3.3 nTPM

Plasma cells	39.1 nTPM
Stomach	84.9 nTPM
Esophagus	36.9 nTPM
Adipose tissue	28.5 nTPM
Spleen	27.3 nTPM
Bone marrow	18.2 nTPM

Respiratory ciliated cells	44.4 nTPM
Bronchus	52.4 nTPM
Lung	36.5 nTPM

Smooth muscle cells	25.2 nTPM
Pancreas	56.9 nTPM
Ovary	30.0 nTPM
Bronchus	26.3 nTPM
Endometrium	24.2 nTPM
Skeletal muscle	24.1 nTPM
Breast	23.6 nTPM
Adipose tissue	23.5 nTPM
Esophagus	20.1 nTPM
Heart muscle	17.5 nTPM
Skin	16.7 nTPM
Prostate	13.8 nTPM

T-cells	21.4 nTPM
Kidney	29.4 nTPM
Liver	29.3 nTPM
Ovary	28.9 nTPM
PBMC	28.2 nTPM
Breast	25.5 nTPM
Bone marrow	24.6 nTPM
Lung	22.8 nTPM
Skeletal muscle	22.6 nTPM
Skin	21.6 nTPM
Stomach	21.2 nTPM
Adipose tissue	20.2 nTPM
Lymph node	20.2 nTPM
Spleen	18.9 nTPM
Colon	17.1 nTPM
Endometrium	15.1 nTPM
Esophagus	13.1 nTPM
Prostate	4.7 nTPM

Basal keratinocytes	12.1 nTPM
Skin	12.1 nTPM

Basal prostatic cells	16.1 nTPM
Prostate	16.1 nTPM

Basal respiratory cells	40.3 nTPM
Bronchus	40.3 nTPM

Cholangiocytes	17.2 nTPM
Liver	17.2 nTPM

Undifferentiated cells	17.3 nTPM
Rectum	20.1 nTPM
Small intestine	18.8 nTPM
Colon	13.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC