Single cell type - AQR - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AQR
Gene descriptionⁱ Full gene name according to HGNC.	Aquarius intron-binding spliceosomal factor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cone photoreceptor cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cone photoreceptor cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AQR is part of cluster 52 Non-specific - Transcription with confidenceⁱ 0.99
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TAF1	TATA-box binding protein associated factor 1	0.6482	9
MAU2	MAU2 sister chromatid cohesion factor	0.5840	52
PDPR	Pyruvate dehydrogenase phosphatase regulatory subunit	0.5487	29
POLR3A	RNA polymerase III subunit A	0.5158	9
EXOSC10	Exosome component 10	0.5101	59
POM121	POM121 transmembrane nucleoporin	0.5076	59
KIAA0586	KIAA0586	0.5054	23
SZT2	SZT2 subunit of KICSTOR complex	0.4985	9
ZZEF1	Zinc finger ZZ-type and EF-hand domain containing 1	0.4951	45
KMT2D	Lysine methyltransferase 2D	0.4914	9
IREB2	Iron responsive element binding protein 2	0.4695	52
CTC1	CST telomere replication complex component 1	0.4684	59
ALG10B	ALG10 alpha-1,2-glucosyltransferase B	0.4599	52
MSI2	Musashi RNA binding protein 2	0.4502	9
CC2D2A	Coiled-coil and C2 domain containing 2A	0.4496	9

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	27.0 nTPM
Breast	27.9 nTPM
Adipose tissue	26.2 nTPM

Alveolar cells type 1	12.8 nTPM
Lung	12.8 nTPM

Alveolar cells type 2	26.0 nTPM
Lung	26.0 nTPM

Astrocytes	45.4 nTPM
Brain	45.4 nTPM

B-cells	27.9 nTPM
Lymph node	38.1 nTPM
Spleen	36.4 nTPM
Stomach	35.9 nTPM
Bone marrow	33.5 nTPM
PBMC	31.5 nTPM
Adipose tissue	31.1 nTPM
Colon	23.9 nTPM
Breast	22.8 nTPM
Liver	21.1 nTPM
Kidney	4.8 nTPM

Dendritic cells	31.4 nTPM
PBMC	35.8 nTPM
Adipose tissue	35.1 nTPM
Breast	23.3 nTPM

Endothelial cells	24.1 nTPM
Skeletal muscle	37.3 nTPM
Lung	31.2 nTPM
Ovary	29.2 nTPM
Eye	29.1 nTPM
Endometrium	28.1 nTPM
Esophagus	27.2 nTPM
Testis	25.8 nTPM
Placenta	23.9 nTPM
Breast	22.4 nTPM
Heart muscle	19.3 nTPM
Pancreas	19.3 nTPM
Prostate	17.8 nTPM
Liver	16.5 nTPM
Skin	9.9 nTPM

Fibroblasts	18.6 nTPM
Lung	31.3 nTPM
Skeletal muscle	27.8 nTPM
Ovary	23.3 nTPM
Breast	21.2 nTPM
Stomach	20.8 nTPM
Adipose tissue	18.9 nTPM
Esophagus	17.2 nTPM
Placenta	15.9 nTPM
Heart muscle	11.5 nTPM
Prostate	9.5 nTPM
Skin	7.4 nTPM

Intestinal goblet cells	19.1 nTPM
Rectum	24.6 nTPM
Small intestine	18.2 nTPM
Colon	14.3 nTPM

Macrophages	21.8 nTPM
Stomach	32.2 nTPM
Bone marrow	31.2 nTPM
Spleen	31.1 nTPM
Lung	30.4 nTPM
Ovary	27.2 nTPM
Skeletal muscle	26.1 nTPM
Adipose tissue	24.5 nTPM
Endometrium	20.9 nTPM
Breast	19.4 nTPM
Esophagus	18.9 nTPM
Kidney	17.5 nTPM
Testis	16.3 nTPM
PBMC	13.6 nTPM
Pancreas	10.2 nTPM
Prostate	6.9 nTPM

Paneth cells	12.1 nTPM
Rectum	18.0 nTPM
Small intestine	15.0 nTPM
Colon	3.3 nTPM

Plasma cells	22.9 nTPM
Adipose tissue	29.1 nTPM
Esophagus	24.6 nTPM
Bone marrow	23.0 nTPM
Spleen	19.2 nTPM
Stomach	18.4 nTPM

Respiratory ciliated cells	27.1 nTPM
Lung	32.1 nTPM
Bronchus	22.2 nTPM

Smooth muscle cells	16.9 nTPM
Esophagus	24.8 nTPM
Adipose tissue	22.6 nTPM
Skeletal muscle	21.9 nTPM
Endometrium	20.9 nTPM
Ovary	20.9 nTPM
Breast	18.5 nTPM
Prostate	14.4 nTPM
Bronchus	12.3 nTPM
Heart muscle	10.7 nTPM
Pancreas	10.1 nTPM
Skin	8.4 nTPM

T-cells	27.0 nTPM
Skeletal muscle	43.5 nTPM
Lung	41.0 nTPM
PBMC	39.8 nTPM
Lymph node	35.0 nTPM
Esophagus	32.8 nTPM
Adipose tissue	32.0 nTPM
Bone marrow	30.3 nTPM
Stomach	29.9 nTPM
Spleen	29.3 nTPM
Endometrium	26.2 nTPM
Breast	26.2 nTPM
Colon	23.3 nTPM
Liver	19.9 nTPM
Kidney	16.4 nTPM
Prostate	14.2 nTPM
Ovary	13.4 nTPM
Skin	6.4 nTPM

Basal keratinocytes	9.6 nTPM
Skin	9.6 nTPM

Basal prostatic cells	13.7 nTPM
Prostate	13.7 nTPM

Basal respiratory cells	17.0 nTPM
Bronchus	17.0 nTPM

Basal squamous epithelial cells	15.4 nTPM
Esophagus	15.4 nTPM

Undifferentiated cells	21.6 nTPM
Rectum	26.3 nTPM
Small intestine	21.2 nTPM
Colon	17.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC