Single cell type - EXOSC10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EXOSC10
Gene descriptionⁱ Full gene name according to HGNC.	Exosome component 10
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

EXOSC10 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ZNF841	Zinc finger protein 841	0.5544	59
MCM3AP	Minichromosome maintenance complex component 3 associated protein	0.5445	59
POM121	POM121 transmembrane nucleoporin	0.5382	59
SMG8	SMG8 nonsense mediated mRNA decay factor	0.5254	59
AQR	Aquarius intron-binding spliceosomal factor	0.5101	52
DDX47	DEAD-box helicase 47	0.5086	59
DPH1	Diphthamide biosynthesis 1	0.5068	59
POLR1A	RNA polymerase I subunit A	0.5027	59
PRPF8	Pre-mRNA processing factor 8	0.5002	9
HEATR1	HEAT repeat containing 1	0.4954	59
BCKDHA	Branched chain keto acid dehydrogenase E1 subunit alpha	0.4897	59
MRPL38	Mitochondrial ribosomal protein L38	0.4863	59
NOP2	NOP2 nucleolar protein	0.4851	59
ZNF549	Zinc finger protein 549	0.4839	52
AARS2	Alanyl-tRNA synthetase 2, mitochondrial	0.4837	23

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	18.4 nTPM
Breast	19.8 nTPM
Adipose tissue	17.1 nTPM

Alveolar cells type 1	28.9 nTPM
Lung	28.9 nTPM

Alveolar cells type 2	18.3 nTPM
Lung	18.3 nTPM

Astrocytes	17.0 nTPM
Brain	17.0 nTPM

B-cells	26.1 nTPM
Bone marrow	54.8 nTPM
Stomach	44.0 nTPM
Lymph node	33.7 nTPM
Spleen	32.2 nTPM
Adipose tissue	19.1 nTPM
Kidney	19.0 nTPM
Liver	18.0 nTPM
PBMC	15.7 nTPM
Breast	13.4 nTPM
Colon	11.2 nTPM

Dendritic cells	18.8 nTPM
Adipose tissue	22.4 nTPM
PBMC	20.0 nTPM
Breast	13.9 nTPM

Endothelial cells	20.1 nTPM
Pancreas	42.5 nTPM
Lung	28.1 nTPM
Ovary	23.3 nTPM
Testis	22.0 nTPM
Esophagus	20.7 nTPM
Skeletal muscle	19.9 nTPM
Placenta	18.8 nTPM
Eye	18.6 nTPM
Heart muscle	17.1 nTPM
Endometrium	17.0 nTPM
Liver	15.6 nTPM
Breast	15.3 nTPM
Skin	12.8 nTPM
Prostate	9.4 nTPM

Fibroblasts	17.2 nTPM
Esophagus	22.9 nTPM
Lung	21.2 nTPM
Skeletal muscle	21.1 nTPM
Ovary	19.5 nTPM
Placenta	19.0 nTPM
Stomach	17.8 nTPM
Adipose tissue	16.8 nTPM
Breast	15.8 nTPM
Skin	14.1 nTPM
Heart muscle	12.0 nTPM
Prostate	9.5 nTPM

Intestinal goblet cells	16.5 nTPM
Colon	20.8 nTPM
Rectum	16.5 nTPM
Small intestine	12.3 nTPM

Macrophages	18.7 nTPM
Esophagus	44.1 nTPM
Stomach	32.2 nTPM
Lung	30.6 nTPM
Bone marrow	21.2 nTPM
Testis	20.9 nTPM
Pancreas	20.4 nTPM
Ovary	19.0 nTPM
Adipose tissue	17.7 nTPM
Endometrium	16.7 nTPM
Spleen	15.6 nTPM
Breast	14.3 nTPM
Skeletal muscle	14.1 nTPM
Kidney	8.3 nTPM
Prostate	5.7 nTPM
PBMC	0.0 nTPM

Paneth cells	9.4 nTPM
Small intestine	15.0 nTPM
Rectum	13.2 nTPM
Colon	0.0 nTPM

Plasma cells	26.8 nTPM
Bone marrow	39.5 nTPM
Spleen	31.8 nTPM
Esophagus	24.6 nTPM
Adipose tissue	21.9 nTPM
Stomach	16.1 nTPM

Respiratory ciliated cells	27.3 nTPM
Lung	35.0 nTPM
Bronchus	19.6 nTPM

Smooth muscle cells	17.6 nTPM
Esophagus	24.8 nTPM
Pancreas	22.6 nTPM
Skeletal muscle	20.9 nTPM
Ovary	20.3 nTPM
Heart muscle	18.9 nTPM
Endometrium	18.5 nTPM
Adipose tissue	18.3 nTPM
Breast	14.6 nTPM
Skin	11.9 nTPM
Prostate	11.6 nTPM
Bronchus	11.4 nTPM

T-cells	21.2 nTPM
Stomach	40.6 nTPM
Bone marrow	38.7 nTPM
Lymph node	29.8 nTPM
Spleen	29.1 nTPM
Lung	22.8 nTPM
Adipose tissue	21.8 nTPM
PBMC	21.7 nTPM
Kidney	21.2 nTPM
Endometrium	19.8 nTPM
Skin	18.0 nTPM
Skeletal muscle	17.7 nTPM
Liver	16.8 nTPM
Breast	16.8 nTPM
Colon	14.2 nTPM
Ovary	13.4 nTPM
Esophagus	13.1 nTPM
Prostate	4.7 nTPM

Basal keratinocytes	13.3 nTPM
Skin	13.3 nTPM

Basal squamous epithelial cells	26.2 nTPM
Esophagus	26.2 nTPM

Collecting duct cells	5.5 nTPM
Kidney	5.5 nTPM

Cone photoreceptor cells	47.9 nTPM
Eye	47.9 nTPM

Undifferentiated cells	20.1 nTPM
Colon	23.5 nTPM
Rectum	20.3 nTPM
Small intestine	16.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC