Single cell type - AKAP11 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AKAP11
Gene descriptionⁱ Full gene name according to HGNC.	A-kinase anchoring protein 11
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Neurons & Oligodendrocytes - Synaptic function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

AKAP11 is part of cluster 8 Neurons & Oligodendrocytes - Synaptic function with confidenceⁱ 0.99
719 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CDC73	Cell division cycle 73	0.5411	8
UTP23	UTP23 small subunit processome component	0.4996	59
NETO1	Neuropilin and tolloid like 1	0.4851	8
FCRL4	Fc receptor like 4	0.4766	57
RIMS1	Regulating synaptic membrane exocytosis 1	0.4690	8
PDXP	Pyridoxal phosphatase	0.4510	8
ZNF860	Zinc finger protein 860	0.4407	57
NUP133	Nucleoporin 133	0.4373	59
RNF111	Ring finger protein 111	0.4357	59
PDE10A	Phosphodiesterase 10A	0.4325	8
GABPA	GA binding protein transcription factor subunit alpha	0.4279	59
JAK2	Janus kinase 2	0.4270	8
PREPL	Prolyl endopeptidase like	0.4235	8
ANKRD34A	Ankyrin repeat domain 34A	0.4206	56
CDK14	Cyclin dependent kinase 14	0.4166	8

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	41.9 nTPM
Adipose tissue	44.6 nTPM
Breast	39.4 nTPM

Alveolar cells type 1	25.6 nTPM
Lung	25.6 nTPM

Alveolar cells type 2	30.5 nTPM
Lung	30.5 nTPM

Astrocytes	58.8 nTPM
Brain	58.8 nTPM

B-cells	42.8 nTPM
Bone marrow	73.6 nTPM
Stomach	70.0 nTPM
Spleen	64.7 nTPM
Adipose tissue	56.1 nTPM
Lymph node	54.7 nTPM
Colon	28.7 nTPM
PBMC	24.3 nTPM
Breast	24.1 nTPM
Kidney	19.0 nTPM
Liver	12.2 nTPM

Dendritic cells	21.2 nTPM
Adipose tissue	22.9 nTPM
Breast	20.7 nTPM
PBMC	20.0 nTPM

Endothelial cells	25.5 nTPM
Lung	40.6 nTPM
Heart muscle	38.3 nTPM
Skeletal muscle	36.2 nTPM
Breast	32.5 nTPM
Esophagus	31.0 nTPM
Eye	30.7 nTPM
Endometrium	27.3 nTPM
Ovary	26.8 nTPM
Testis	21.7 nTPM
Liver	21.1 nTPM
Placenta	15.9 nTPM
Skin	14.9 nTPM
Prostate	12.5 nTPM
Pancreas	7.7 nTPM

Fibroblasts	27.5 nTPM
Heart muscle	48.8 nTPM
Esophagus	37.1 nTPM
Skeletal muscle	35.9 nTPM
Stomach	31.2 nTPM
Adipose tissue	29.2 nTPM
Breast	27.3 nTPM
Ovary	26.0 nTPM
Skin	20.2 nTPM
Lung	20.1 nTPM
Prostate	18.6 nTPM
Placenta	7.6 nTPM

Intestinal goblet cells	14.9 nTPM
Rectum	19.7 nTPM
Small intestine	15.1 nTPM
Colon	10.0 nTPM

Macrophages	25.0 nTPM
Spleen	41.4 nTPM
Bone marrow	41.2 nTPM
Esophagus	39.3 nTPM
Lung	31.8 nTPM
Ovary	30.7 nTPM
Adipose tissue	30.1 nTPM
Skeletal muscle	28.2 nTPM
Testis	23.8 nTPM
Stomach	23.5 nTPM
Kidney	22.7 nTPM
Breast	20.0 nTPM
Endometrium	18.8 nTPM
Prostate	12.6 nTPM
Pancreas	10.2 nTPM
PBMC	0.0 nTPM

Paneth cells	15.4 nTPM
Small intestine	18.8 nTPM
Rectum	17.4 nTPM
Colon	9.9 nTPM

Plasma cells	27.0 nTPM
Stomach	36.9 nTPM
Esophagus	30.7 nTPM
Adipose tissue	26.4 nTPM
Spleen	21.1 nTPM
Bone marrow	19.8 nTPM

Respiratory ciliated cells	33.1 nTPM
Lung	33.5 nTPM
Bronchus	32.5 nTPM

Smooth muscle cells	27.1 nTPM
Heart muscle	48.0 nTPM
Esophagus	43.4 nTPM
Adipose tissue	37.4 nTPM
Skeletal muscle	29.4 nTPM
Breast	27.0 nTPM
Endometrium	26.2 nTPM
Prostate	21.3 nTPM
Ovary	19.8 nTPM
Skin	19.2 nTPM
Pancreas	15.8 nTPM
Bronchus	10.4 nTPM

T-cells	25.4 nTPM
Adipose tissue	42.6 nTPM
Spleen	38.5 nTPM
Lung	38.0 nTPM
Bone marrow	37.3 nTPM
Lymph node	36.5 nTPM
Stomach	32.9 nTPM
Skeletal muscle	31.4 nTPM
Breast	26.7 nTPM
PBMC	26.1 nTPM
Skin	25.4 nTPM
Endometrium	20.2 nTPM
Esophagus	19.7 nTPM
Kidney	17.1 nTPM
Liver	16.7 nTPM
Colon	14.2 nTPM
Ovary	8.9 nTPM
Prostate	0.0 nTPM

Basal prostatic cells	13.7 nTPM
Prostate	13.7 nTPM

Basal squamous epithelial cells	14.8 nTPM
Esophagus	14.8 nTPM

Cholangiocytes	12.8 nTPM
Liver	12.8 nTPM

Collecting duct cells	29.5 nTPM
Kidney	29.5 nTPM

Undifferentiated cells	12.3 nTPM
Rectum	15.8 nTPM
Small intestine	11.6 nTPM
Colon	9.6 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC