Single cell type - UTP23 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UTP23
Gene descriptionⁱ Full gene name according to HGNC.	UTP23 small subunit processome component
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

UTP23 is part of cluster 59 Non-specific - Transcription with confidenceⁱ 0.93
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NBPF15	NBPF member 15	0.5873	43
C17orf80	Chromosome 17 open reading frame 80	0.5144	66
SPARCL1	SPARC like 1	0.5063	14
C5orf51	Chromosome 5 open reading frame 51	0.5005	59
AKAP11	A-kinase anchoring protein 11	0.4996	8
FMO2	Flavin containing dimethylaniline monoxygenase 2	0.4986	14
SHANK3	SH3 and multiple ankyrin repeat domains 3	0.4936	14
CLK2	CDC like kinase 2	0.4926	43
HP1BP3	Heterochromatin protein 1 binding protein 3	0.4891	43
TGS1	Trimethylguanosine synthase 1	0.4841	59
ZNF41	Zinc finger protein 41	0.4788	8
RBM48	RNA binding motif protein 48	0.4746	52
MRTFB	Myocardin related transcription factor B	0.4724	43
ZFR	Zinc finger RNA binding protein	0.4710	10
RBM19	RNA binding motif protein 19	0.4593	59

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	33.6 nTPM
Breast	35.2 nTPM
Adipose tissue	32.1 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	33.1 nTPM
Lung	33.1 nTPM

Astrocytes	36.2 nTPM
Brain	36.2 nTPM

B-cells	31.0 nTPM
Stomach	38.6 nTPM
Spleen	35.0 nTPM
Adipose tissue	34.5 nTPM
Kidney	33.4 nTPM
PBMC	32.9 nTPM
Bone marrow	31.1 nTPM
Lymph node	30.0 nTPM
Colon	27.1 nTPM
Liver	25.1 nTPM
Breast	22.8 nTPM

Dendritic cells	24.8 nTPM
Adipose tissue	40.7 nTPM
Breast	21.8 nTPM
PBMC	12.0 nTPM

Endothelial cells	28.7 nTPM
Heart muscle	83.5 nTPM
Lung	46.8 nTPM
Esophagus	37.7 nTPM
Skeletal muscle	29.5 nTPM
Prostate	26.2 nTPM
Endometrium	26.2 nTPM
Breast	24.6 nTPM
Testis	24.0 nTPM
Placenta	20.5 nTPM
Ovary	19.8 nTPM
Liver	18.3 nTPM
Skin	18.1 nTPM
Eye	15.4 nTPM
Pancreas	11.6 nTPM

Fibroblasts	32.9 nTPM
Heart muscle	63.9 nTPM
Adipose tissue	39.8 nTPM
Stomach	37.1 nTPM
Skeletal muscle	34.6 nTPM
Prostate	31.4 nTPM
Esophagus	30.8 nTPM
Lung	30.1 nTPM
Placenta	29.4 nTPM
Breast	29.3 nTPM
Skin	19.9 nTPM
Ovary	15.8 nTPM

Intestinal goblet cells	16.6 nTPM
Small intestine	17.8 nTPM
Colon	16.5 nTPM
Rectum	15.4 nTPM

Macrophages	18.5 nTPM
Lung	40.2 nTPM
Endometrium	31.4 nTPM
Adipose tissue	21.9 nTPM
Breast	21.1 nTPM
Bone marrow	18.8 nTPM
Spleen	18.6 nTPM
Pancreas	17.8 nTPM
Ovary	16.9 nTPM
Kidney	16.6 nTPM
Skeletal muscle	16.5 nTPM
Testis	15.1 nTPM
Stomach	14.7 nTPM
PBMC	13.6 nTPM
Esophagus	11.0 nTPM
Prostate	3.4 nTPM

Paneth cells	9.4 nTPM
Rectum	13.7 nTPM
Small intestine	11.3 nTPM
Colon	3.3 nTPM

Plasma cells	32.0 nTPM
Esophagus	43.0 nTPM
Spleen	41.6 nTPM
Stomach	35.2 nTPM
Bone marrow	23.0 nTPM
Adipose tissue	17.4 nTPM

Respiratory ciliated cells	19.2 nTPM
Lung	26.2 nTPM
Bronchus	12.1 nTPM

Smooth muscle cells	26.4 nTPM
Heart muscle	53.9 nTPM
Adipose tissue	36.0 nTPM
Skeletal muscle	30.5 nTPM
Ovary	28.4 nTPM
Breast	28.3 nTPM
Endometrium	25.5 nTPM
Esophagus	24.8 nTPM
Pancreas	20.9 nTPM
Skin	19.5 nTPM
Prostate	15.7 nTPM
Bronchus	6.6 nTPM

T-cells	29.5 nTPM
Lung	54.6 nTPM
Stomach	42.6 nTPM
Adipose tissue	40.0 nTPM
Lymph node	39.0 nTPM
Spleen	36.4 nTPM
Endometrium	33.5 nTPM
PBMC	33.3 nTPM
Bone marrow	32.2 nTPM
Colon	30.4 nTPM
Breast	26.5 nTPM
Ovary	24.5 nTPM
Skeletal muscle	23.6 nTPM
Liver	21.3 nTPM
Kidney	19.1 nTPM
Prostate	19.0 nTPM
Esophagus	13.1 nTPM
Skin	11.6 nTPM

Basal prostatic cells	27.0 nTPM
Prostate	27.0 nTPM

Basal squamous epithelial cells	31.9 nTPM
Esophagus	31.9 nTPM

Collecting duct cells	7.3 nTPM
Kidney	7.3 nTPM

Cone photoreceptor cells	6.2 nTPM
Eye	6.2 nTPM

Undifferentiated cells	16.6 nTPM
Small intestine	18.8 nTPM
Rectum	16.5 nTPM
Colon	14.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC